Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
Granted: November 19, 2024
Patent Number:
12145943
The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.
Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
Granted: October 15, 2024
Patent Number:
12116374
The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.
Treatment of idiopathic pulmonary fibrosis with glycogen synthase kinase 3 form ? inhibitors
Granted: September 10, 2024
Patent Number:
12083098
Pharmaceutical compositions and methods are described which rely upon glycogen synthase kinase 3 (form ?; GSK 3 ?) inhibitors, most preferably 9-ING-41, to inhibit fibrotic pulmonary remodeling in vivo including proliferation and differentiation of myofibroblasts to fibrotic fibroblasts in several mouse models. Therapeutic targeting of GSK-3? with the clinically useful specific inhibitor, 9-ING-41, mitigates fibrotic pulmonary remodeling in vivo and provides a mode of therapy of human…
Methods of treating malignant lymphoproliferative disorders
Granted: May 14, 2024
Patent Number:
11980607
Methods of treating malignant lymphoproliferative disorders in a patient, comprising administering an effective amount of a GSK-3? inhibitor, for example 9-ING-41, are provided. Also provided are methods for treating malignant lymphoproliferative disorders comprising administering a GSK-3? inhibitor, for example 9-ING-41, in combination with a second or multiple therapeutic agents.
Lancing device having anesthetic feature
Granted: November 7, 2023
Patent Number:
11806143
A handheld lancing device having anesthetic feature includes a housing removably retaining a disposable lancet. A carriage suspended within the housing by an isolation assembly may receive the lancet. A motor in mechanical communication with the lancet produces vibrations transmitted to contact surface, which vibrate a target lancing site prior to and during piercing. The target site is vibrated for a predetermined period of time before deploying the lancet. The isolation assembly…
Methods of treating malignant lymphoproliferative disorders
Granted: November 29, 2022
Patent Number:
11510904
Methods of treating malignant lymphoproliferative disorders in a patient, comprising administering an effective amount of a GSK-3? inhibitor, for example 9-ING-41, are provided. Also provided are methods for treating malignant lymphoproliferative disorders comprising administering a ({umlaut over (?)}8K-3? inhibitor, for example 9-ING-41, in combination with a second or multiple therapeutic agents.
Handset for occlusion clearing device
Granted: October 19, 2021
Patent Number:
11147944
A handset for operation and locking of an occlusion clearing device includes a body and movable cover. Valve(s) in fluid communication with tubing for aspiration or irrigation are located within the body. A locking mechanism having first and second components affixed at different points in the handset which are selectively movable relative to one another to transition between locked and unlocked positions. The first component is connected to and selectively movable relative to the cover.…
Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione
Granted: October 5, 2021
Patent Number:
11136334
The present disclosure relates to solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione, processes for preparation thereof, pharmaceutical compositions thereof, and uses thereof in treating disease.
Reduced force device for intravascular access and guidewire placement
Granted: March 9, 2021
Patent Number:
10940292
A device for penetrating tissue with reduced force and placing a guidewire is provided. The device includes a driving actuator generating reciprocating motion at less than 20 kHz. A penetrating member having a lumen dimensioned to accommodate a guidewire is provided, and may be coaxial or axially offset from the driving actuator. A coupler mechanically connects the driving actuator and the penetrating member, transferring the reciprocating motion to the penetrating member. At least one…
Device for in situ clearing of occlusions in tubing
Granted: July 9, 2019
Patent Number:
10342902
An occlusion clearing device and system for removing material from an artificial tube in situ includes a clearing stem having aspiration and irrigation conduits, where the irrigation conduit is disposed interior to, and terminates within the aspiration conduit. Material enters the clearing stem through aspiration, and irrigation is provided within the aspiration conduit to assist in aspiration through the clearing stem. A handset includes aspiration and irrigation tubing connecting to…
Devices for clearing blockages in artificial and natural lumens
Granted: June 4, 2019
Patent Number:
10307340
An occlusion clearing device for a patient has a housing with a motor(s) that generates repetitive motion, which is reciprocating, rotational or both. A clearing stem including a sheath that has a lumen, wherein aspiration is conducted through the sheath lumen. A wire is located in the sheath lumen and receives repetitive motion from the controller. The sheath terminates in a sheath end having at least one sheath opening. The wire terminates in a wire tip, which may be flat, helical, or…
Device and method for less forceful tissue puncture
Granted: March 5, 2019
Patent Number:
10219832
A device for penetrating tissue is provided that has a driving actuator with a body and motor shaft that is reciprocated. A coupler is attached to the motor shaft, and a key engages the driving actuator and coupler and limits rotational motion of the motor shaft and permits linear motion of the motor shaft. A penetrating member is carried by the coupler, and linear motion of the motor shaft is translated to the penetrating member to linearly reciprocate the penetrating member.
Miniature device platform for navigation on moving organs
Granted: September 11, 2018
Patent Number:
10070880
A device for gripping tissue that is inside of a patient for use in delivering therapy is provided. The device may include a first gear that rotates and that engages the tissue. A second gear that also rotates may be included and may likewise engage the tissue. A spacing mechanism may be included in the device that adjusts the spacing between the first and second gears such that the first and second gears are moved closer to one another and moved farther from one another.
Reduced force device for intravascular access and guidewire placement
Granted: June 5, 2018
Patent Number:
9987468
A device for penetrating tissue with reduced force and placing a guidewire is provided. The device includes a driving actuator generating reciprocating motion. A penetrating member having a lumen dimensioned to accommodate a guidewire is provided. A coupler mechanically connects the driving actuator and the penetrating member to transfer the reciprocating motion to the penetrating member. The penetrating member may be coaxial or axially offset from the driving actuator. At least one…
Performing data mining operations within a columnar database management system
Granted: October 24, 2017
Patent Number:
9798783
Data mining operations are performed within a columnar database management system. The columnar database management system stores input sets of data for a data mining operation. An input set of data is represented as a column of data in the columnar database management system. The columnar database management system stores instructions to perform one or more data mining operations for processing the input sets of data. The columnar database management system receives requests for…
Generating a venn diagram using a columnar database management system
Granted: June 13, 2017
Patent Number:
9679000
Venn diagrams are computed for a given plurality of input sets. The process of computing the Venn diagrams is executed on columnar database systems for efficient execution. The computation of various subsets of the Venn diagrams is performed by determining subsets of various combinations of the input sets and computing set differences of the intersection sets. The process orders the execution of various steps of computing the subsets for the Venn diagram in an order that reduces the…
Performing cross-tabulation using a columnar database management system
Granted: March 21, 2017
Patent Number:
9600539
Cross tabulation operation is performed within a columnar database management system. The columnar database management system receives a request to perform a cross-tabulation operation on a set of database tables. The columnar database management system determines values of cross tabulation operation for each row of the result. The columnar database management system determines a domain for each value of the row dimension corresponding to a row combination. The columnar database…
Active system for in-situ clearing of secretions and occlusions in tubes
Granted: February 7, 2017
Patent Number:
9561337
A device for removing secretions from an artificial tube is provided. The device may include a clearing catheter and a driving mechanism that may apply repetitive motion to the clearing catheter. In another version of the device, the clearing catheter may dispense irrigation fluid and aspirate the irrigation fluid. The clearing catheter may have an irrigation and an aspiration lumen that may both reciprocate with the clearing catheter. In another version a compliant member into which…
Devices for clearing blockages in small bore in-situ artificial lumens
Granted: May 31, 2016
Patent Number:
9352122
A device for clearing blockages is provided that may have a tube that is slit. The tube may have a lumen. A reciprocating member may be provided and a portion of the reciprocating member may be located within the lumen.
Devices and methods for clearing occlusions and for providing irrigation in in-situ artificial and natural lumens
Granted: April 12, 2016
Patent Number:
9308348
Devices and methods for the effective clearing of artificial tubes, for example, in-situ clearing of artificial tubes in a living being are covered in this disclosure. The devices and methods provide a controller comprising at least one actuator for generating repetitive motion, and a stem coupled to the at least one actuator. The stem includes at least one fluid source, a conduit member in fluidic communication with the fluid source, and a reciprocating member at least partially…
