OSCILLOSCOPE WITH INTERNALLY GENERATED MIXED SIGNAL OSCILLOSCOPE DEMO MODE STIMULUS, AND INTEGRATED DEMONSTRATION AND TRAINING SIGNALS
Granted: November 1, 2012
Application Number:
20120274313
An oscilloscope includes at least one demonstration signal generator integrated as part of the oscilloscope. The demonstration signal generator generates stimulus signals that consist of digital samples of various different stored waveforms without the need of a separate demonstration board or signal source. The demonstration signal generator may loop through different sections of the stored waveforms to generate respective stimulus signals that include sequences of digital samples from…
OSCILLOSCOPE WITH INTEGRATED GENERATOR AND INTERNAL TRIGGER
Granted: October 25, 2012
Application Number:
20120268101
An apparatus, includes an oscilloscope and a waveform generator. The waveform generator is integrated in a common housing with the oscilloscope, and configured to provide a stimulus signal as an output of the apparatus and to provide a trigger signal that is connected internally to the oscilloscope for triggering the oscilloscope.
BALANCED FEATURE DISPLAY IN FLUIDIC SAMPLE SEPARATION
Granted: October 18, 2012
Application Number:
20120265448
A device for processing measurement data assigned to a measurement on a fluidic sample to be separated, the measurement data having multiple features being indicative of different fractions of the fluidic sample, the device includes a feature position analysis unit configured for analyzing positions (p1, p2, d1, d2) of at least a part of the features relative to one another, and a display adjustment unit configured for adjusting, based on a result of the analyzing, a mode of displaying…
FLUIDIC CHIP WITH LAMINATED REINFORCING LAYER FOR PRESSURE REINFORCEMENT
Granted: October 4, 2012
Application Number:
20120251410
A fluidic chip device configured for processing a fluidic sample includes two outer boundary layers, and at least one reinforcing layer arranged between the two outer boundary layers and being at both of its opposing main surfaces laminated with directly adjacent layers to reinforce pressure resistance of the fluidic chip device by the lamination, in which at least a part of the layers of the fluidic chip device includes a hole forming at least a part of a fluidic conduit for conducting…
METHOD AND SYSTEM FOR PROVIDING PHASE REFERENCE SIGNAL
Granted: September 27, 2012
Application Number:
20120243595
A method and system of providing a phase reference signal includes generating a reference signal having a reference frequency, modulating the reference signal at a modulation frequency lower than the reference frequency to obtain a modulated drive signal, receiving the modulated drive signal at a phase reference, and generating the phase reference signal based on the modulated drive signal. The phase reference signal including multiple reference tones having corresponding tone…
THIOCARBON-PROTECTING GROUPS FOR RNA SYNTHESIS
Granted: September 20, 2012
Application Number:
20120238737
Aspects of the invention include 2? protected nucleoside monomers that are protected at the 2? site with thiocarbon protecting groups. Thiocarbon protecting groups of interest include thiocarbonate, thionocarbonate, dithiocarbonate groups, as well as thionocarbamate protecting groups. Aspects of the invention further include nucleic acids that include the protecting groups of the invention, as well as methods of synthesizing nucleic acids using the protecting groups of the invention.
PRIMARY PISTON CORRECTION DURING TRANSFER
Granted: August 30, 2012
Application Number:
20120216886
A method for controlling operation of a pump unit, where the pump unit includes a primary piston pump having a primary piston and a secondary piston pump having a secondary piston. The primary piston pump is fluidically connected with the secondary piston pump. The primary piston pump includes an inlet valve and an outlet valve, and the pump unit operates periodically according to a pump cycle. The method includes determining a fluid pressure of fluid dispensed by the pump unit, and…
PROBES FOR SPECIFIC ANALYSIS OF NUCLEIC ACIDS
Granted: August 30, 2012
Application Number:
20120220479
The present invention provides a method for detecting or enriching for a target deoxyribonucleic acid (DNA) present in a nucleic acid sample, said method comprising: (a) fragmenting a nucleic acid sample to generate nucleic acid fragments including a target fragment containing said target DNA; (b) rendering said fragments, including said target fragment, at least partially single-stranded, wherein the single-stranded portion includes an end portion and wherein the length of said…
SUSPENDED SUBSTRATE CIRCUITS AND NUCLEAR MAGNETIC RESONANCE PROBES UTILIZING SAME
Granted: August 23, 2012
Application Number:
20120212224
A nuclear magnetic resonance (NMR) probe circuit assembly includes one or more probe circuits in signal communication with one or more respective sample coils configured for transmitting and/or receiving radio-frequency (RF) energy to and/or from a sample of interest. One or more of the probe circuits have a suspended substrate configuration in which variable capacitors share a common dielectric substrate that is separated from a ground plane by an air gap. Each variable capacitor…
LIQUID SUPPLY WITH OPTIMIZED SWITCHING BETWEEN DIFFERENT SOLVENTS
Granted: August 9, 2012
Application Number:
20120198919
A method for metering two or more liquids in controlled proportions in a liquid supply system and for supplying a resultant mixture, in which the liquid supply system includes a plurality of solvent supply lines, a proportioning valve interposed between the solvent supply lines and an inlet of a pumping unit, the method includes drawing in a first liquid into the pumping unit via a first solvent supply line; determining one or more switching points of time for switching between different…
COLUMN ASSEMBLY FOR A GAS CHROMATOGRAPH
Granted: August 9, 2012
Application Number:
20120198913
A column assembly for gas chromatography, which is coolable by a fluid, includes a capillary column, a heating element for heating at least a portion of the capillary column, and a tube having a lumen and in contact with at least one of the capillary column and the heating element. When energized, the heating element raises the temperature of the capillary column. To lower the temperature of the capillary column, a fluid flows through the tube, and heat is transferred from the capillary…
MASS SPECTROMETER AND MASS ANALYZER COMPRISING PULSER
Granted: August 2, 2012
Application Number:
20120193524
A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite one another, parallel to one another, and axially offset from one another. One of the pair of planar electrodes comprises an opening. The mass analyzer comprises an ion mirror disposed between the pair of planar electrodes. A mass spectrometer and a mass spectrometry method are also described.
DEVICE AND METHOD FOR DRIVING DIGITAL-TO-ANALOG CONVERTER
Granted: August 2, 2012
Application Number:
20120194373
A device for driving a switch in a digital-to-analog converter (DAC) includes first and second latches, and a logic gate. The first latch is configured to store a digital input data signal according to a clock signal, and to output a first latch signal corresponding to the stored digital input data signal. The second latch is configured to store the first latch signal output by the first latch according to a logical inverse of the clock signal, and to output a second latch signal…
APPARATUS AND METHODS FOR MICROFLUIDIC APPLICATIONS
Granted: August 2, 2012
Application Number:
20120195809
Non-rigid tape apparatus and fabrication methods for microfluidic processing applications such as gel electrophoresis are provided, where microfluidic processing is performed on selected areas. Parts of the tape are formed by high pressure plastic film forming. Membranes and other structures are self sealing during and after penetration by pipettes and electrical probes. Rigid exoskeleton elements protect the non-rigid parts during processing and facilitate transport of the tape.
PROTECTED MONOMERS AND METHODS OF DEPROTECTION FOR RNA SYNTHESIS
Granted: July 19, 2012
Application Number:
20120184724
A nucleoside monomer that is protected by a thionocarbamate protecting group and contains one or more 2H, 13C, or 15N isotopes in the ribose and/or base part is provided, as well as a method for making a polynucleotide that uses the same. Also provided is a polynucleotide synthesis method that employs a diamine to deprotect a protected polynucleotide.
MULTI-CHANNEL FILTER ASSEMBLY AND RELATED APPARATUS AND METHODS
Granted: June 28, 2012
Application Number:
20120159761
A filter assembly includes a housing and filter elements. The housing includes internal chambers between first and second parallel outside surfaces, fluid inlet bores, and fluid outlet bores. Each internal chamber includes a filter element that partitions the internal chamber into an inlet chamber section and an outlet chamber section. The housing establishes a plurality of fluid flow channels from the inlet bores, through the inlet chamber sections, through the filter elements, through…
LARGE-AREA SOLID PHASE EXTRACTION APPARATUS AND METHODS
Granted: June 28, 2012
Application Number:
20120160038
A solid phase extraction apparatus includes a sample adsorption assembly and a needle. The adsorption assembly includes a housing, a distal housing opening, and an adsorption bar disposed in the housing. The adsorption bar includes an outer surface coated with an adsorption material. The adsorption bar is located between the distal housing opening and a proximal housing opening. The outer surface is spaced from an inner housing surface, wherein the adsorption assembly includes an…
DUAL MATERIAL APPROACH FOR HIGH PRESSURE BIO INERT FLOW PATH COMPONENTS
Granted: June 28, 2012
Application Number:
20120160754
A method of manufacturing a component (400) having a flow path (402), wherein the method comprises forming a high pressure resistant casing (102) with a cavity (202) therein, inserting a bioinert material (302) into the cavity (202) to thereby form a composite block (300), and further processing the composite block (300) for at least partially forming the flow path (402) defined by the component (400).
CERAMIC INJECTION NEEDLE
Granted: June 28, 2012
Application Number:
20120164026
A needle (300) for handling a fluid in an analysis system (10), the needle (300) comprising a needle body (302) made of a ceramic material and having a fluid conduit (304) extending between a fitting end (306) and a seat end (308), the fitting end (306) being connectable to a fitting (402) and the seat end (308) being insertable into a seat (602), wherein the needle body (302) is tapering, particularly conically tapering, towards the fitting end (306), a fixing body (310) arranged on the…
MRI Short Coils
Granted: June 21, 2012
Application Number:
20120153955
According to one aspect, a magnetic resonance imaging (MRI) scanner includes a short birdcage (e.g. millipede) distributed-capacitance radio-frequency (RF) coil formed from one or more patterned planar conductive foils. The transverse extent (e.g. diameter) of the coil is at least a factor of 3, for example about a factor of 10, larger than the longitudinal (z-axis) extent of the coil. Flux-return gaps may be provided between the sample measurement volume defined by the coil and RF…
