SUPERCONDUCTING MAGNET ARRANGEMENT AND METHOD OF MOUNTING THEREOF
Granted: December 15, 2011
Application Number:
20110304416
The method provides a superconducting magnet arrangement (10), a method of mounting the magnet arrangement, and a kit for assembling a magnet arrangement. The magnet arrangement comprises: a pair of spaced apart coil members (34a, 34a?, 34a?; 34b, 34b?, 34b?), wherein the coil members are axially aligned along a common axis (12); a pair of spaced apart preferably toroidal chambers (33a, 33b), wherein the chambers are aligned along the common axis (12), wherein each chamber houses one of…
Fitting Element with Grip Force Distributor
Granted: December 15, 2011
Application Number:
20110303593
A fitting element, in particular for an HPLC application, is configured for providing a fluidic coupling of a tubing to a fluidic device. The fitting element includes a gripping piece configured to exert, upon coupling of the tubing to the fluidic device, a grip force between the fitting element and the tubing. The gripping piece includes a grip force distributor configured to transform an axial force, provided in an axial direction with respect to the tubing, into a plurality of…
FLUID FLOW CONTROL IN A MICROFLUIDIC DEVICE
Granted: December 1, 2011
Application Number:
20110290330
A method for removing fluid in a microfluidic device, the microfluidic device having a fluid channel, a first well, and a second well, the first well and the second well being coupled to a first end of the fluid channel, the method including applying a pressure difference between the second well and the first well, and applying a pressure difference between the first end and a second end of the fluid channel being below a certain threshold, for at least partly removing a first fluid from…
SYSTEM AND METHOD OF DATA-DEPENDENT ACQUISITION BY MASS SPECTROMETRY
Granted: November 24, 2011
Application Number:
20110288779
Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are…
ION GUIDES AND COLLISION CELLS
Granted: November 17, 2011
Application Number:
20110278450
In an embodiment, a collision cell comprises rods each having a first end and a second end remote from the first end; an inductor connected between adjacent pairs of rods; and means for applying a radio frequency (RF) voltage between adjacent pairs of rods. The RF voltage creates a multipole field in a region between the rods; and means for applying a direct current (DC) voltage drop along a length of each of the rods.
SEPARATION DEVICE HAVING COUPLED SEPARATION DEVICE ELEMENTS
Granted: November 10, 2011
Application Number:
20110272356
A separation device has a first separation chamber for housing a packing material representing a stationary phase configured for separating compounds of a fluid sample. The separation device comprises a first separation device element and a second separation device element, configured to be coupled together to provide the first separation chamber. Each of the first separation device element and the second separation device element comprises a retaining element configured to retain the…
Chromatography System with Fluid Intake Management
Granted: October 27, 2011
Application Number:
20110259451
A method of determining a leak in a pumping system includes determining a metered flow rate of a fluid through a first channel, determining a measured flow rate within the channel, and identifying an amount of a leak in the pumping system as the difference between the metered flow rate and the measured flow rate.
VIBRATION DAMPER FOR VACUUM PUMPS
Granted: October 20, 2011
Application Number:
20110254263
In a vibration damper of a turbomolecular vacuum pump, a vacuum tightness function and a vibration damping function are both performed by one or more toroidal rings made of an elastic material. The elastic rings assume a resting configuration while the vacuum pump is not operating and the damper is at atmospheric pressure, and they assume a compressed configuration while the vacuum pump is operating and the damper is under vacuum conditions. In the compressed configuration, the elastic…
APPARATUS AND METHOD FOR CONTROLLING CONSTANT MASS FLOW TO GAS CHROMATOGRAPHY COLUMN
Granted: October 6, 2011
Application Number:
20110239860
A device for providing a constant mass flow rate to a downstream column system of a gas chromatograph includes a small full scale mass flow controller that controls carrier gas to flow at a first mass flow rate and a flow resistance element, including an inlet port connected to a sample inlet, an outlet port connected to the downstream column system, and a pressure sensing port in fluid communication with the outlet port and the mass flow controller. A sample inlet pressure controller…
THERMAL MODULATION DEVICE FOR TWO DIMENSIONAL GAS CHROMATOGRAPHY
Granted: September 29, 2011
Application Number:
20110232366
A thermal modulation device for a gas chromatography (GC) system a cold zone, a first hot zone and a second hot zone, which are located outside of a GC oven of the GC system, and a flexible capillary column. The cold zone includes a thermoelectric cooler assembly. The first hot zone is adjacent a first side of the cold zone, and has a corresponding first heat source. The second hot zone is adjacent a second side of the cold zone, and has a corresponding second heat source. The flexible…
STABILIZATION OF NUCLEIC ACIDS ON SOLID SUPPORTS
Granted: September 22, 2011
Application Number:
20110230653
The present invention provides methods, compositions, and kits for the storage and stabilization of biological molecules. The methods comprise applying Tris(2-carboxyethyl)phosphine (TCEP) to at least one biological molecule bound to a solid substrate and storing in an organic solvent. Preferably, the biological molecules are nucleic acids. Compositions and kits for performing the process according to the invention are also provided.
Temperature Adjustment of a Fluidic Sample within a Fluidic Device
Granted: September 15, 2011
Application Number:
20110220590
A fluidic device configured for separating components of a fluid includes a flow path within an interior of the fluidic device, and at least one heatable frit positioned in the flow path and arranged to selectively adjust a temperature of the fluid in the flow path within the interior of the fluidic device.
DEGASSER WITH VENT IN VACUUM CHAMBER
Granted: September 8, 2011
Application Number:
20110214571
A degassing apparatus (27) for degassing a liquid (240) comprises a vacuum chamber (200), a liquid conveyance member (210) disposed in the vacuum chamber (200) and adapted for transporting the liquid (240), and a pump (220) adapted to evacuate the vacuum chamber (200). The vacuum chamber (200) comprises a vent (270) adapted for venting the vacuum chamber (200).
Method Transfer Between Fluidic Devices Considering Deviations from Ideal Behavior
Granted: September 1, 2011
Application Number:
20110209766
An apparatus (200) for deriving an operation mode from a first fluidic device to a second fluidic device, wherein the first fluidic device has a first target operation mode (300) representing a desired behavior of the first fluidic device and has a first real operation mode (304) representing the actual behavior of the first fluidic device, wherein the second fluidic device has a second target operation mode (312) representing a desired behavior of the second fluidic device and has a…
PHASE- LOCKED LOOP WITH SWITCHED PHASE DETECTORS
Granted: August 25, 2011
Application Number:
20110204937
A phase-locked loop includes: a voltage-controlled oscillator (VCO) system receiving one or more control signals and in response thereto generating a PLL output signal; a plurality of phase detectors for comparing a reference signal having a reference frequency to a PLL feedback signal having a PLL feedback frequency derived from the PLL output signal, and in response thereto to output a comparison signal; and a plurality of signal processing paths each connected to an output of a…
Flow Distribution Mixer
Granted: August 11, 2011
Application Number:
20110192217
A mixer for mixing a fluid having a property varying along a flow direction of the fluid includes an inlet configured for receiving an inlet flow, an outlet configured for providing an outlet flow, and a plurality of flow channels coupled between the inlet and the outlet. The mixer also includes a flow distributor for distributing the inlet flow into the plurality of flow channels so that each flow channel receives a partial flow from the inlet flow, and a flow combiner for combining the…
SEALING CONFIGURATION WITH METAL-COATED STRUCTURE
Granted: August 4, 2011
Application Number:
20110186497
A sealing configuration is configured for sealingly coupling a first fluid flow path of a first device to a second fluid flow path of a second device. The sealing configuration comprises a contact surface comprising a structure configured for increasing a surface pressure when coupling the first device to the second device. The contact surface comprises a metal coating configured for increasing sealing.
DEVICE AND METHOD USING MICROPLASMA ARRAY FOR IONIZING SAMPLES FOR MASS SPECTROMETRY
Granted: July 28, 2011
Application Number:
20110180699
A device includes a first substrate having a principal surface having a plurality of sample sites having a corresponding sample; a second substrate having a principal surface facing and spaced apart from the principal surface of the first substrate, the second substrate having a plurality of ultraviolet emission sites corresponding to the sample sites of the first substrate, each of the ultraviolet emission sites being spaced apart from and facing a corresponding one of the sample sites…
CENTRAL LENS FOR CYLINDRICAL GEOMETRY TIME-OF-FLIGHT MASS SPECTROMETER
Granted: July 28, 2011
Application Number:
20110180702
A mass analyzer comprises a pair of planar electrode structures. The electrode structures are disposed opposite to each other, parallel to each other, and axially offset from each other. The electrode structures are configured to generate, in response to an applied voltage, a cylindrically-symmetric, annular electric field comprising an annular radially focusing central lens region surrounding an axis of symmetry, and an annular mirror region surrounding the annular radially focusing…
APPARATUS ENABLING PARALLEL TRANSMISSIONS OVER TRANSMISSION LINES HAVING DIFFERENT LENGTHS
Granted: July 28, 2011
Application Number:
20110181370
A signal bus includes multiple interconnects for transporting electronic signals. The interconnects have different physical path lengths and different structures to equalize the different the physical path lengths, so that the electronic signals traverse the corresponding interconnects in same period of time.
