TIP FOR INTERFACE CONES
Granted: January 19, 2023
Application Number:
20230013904
A tip including an alloy of platinum and an alloying element chosen from gold, palladium, ruthenium, osmium, iron, cobalt, nickel, copper, zinc, silver, chromium, manganese, titanium, niobium, scandium, vanadium, yttrium, zirconium, molybdenum, tantalum, tungsten, technetium, cadmium, hafnium, rhenium, less than 5 wt. % of iridium, less than 5 wt. % of rhodium, greater than 20 wt. % iridium, greater than 20 wt. % rhodium, and a combination thereof, relative to the total weight of the…
MULTI-DEVICE REMOVAL AND INSTALLATION TOOL
Granted: January 19, 2023
Application Number:
20230017417
In some examples, a multi-device removal and installation tool may include a device removal tool including a first side having a first receiver with a first dimension that removably receives a first device, and a second side having a second receiver with a second dimension that removably receives a second device. The first dimension may be different from the second dimension. A torque limit tool may apply, in a first rotation direction of the torque limit tool and the device removal…
TIP FOR INTERFACE CONES
Granted: January 19, 2023
Application Number:
20230013904
A tip including an alloy of platinum and an alloying element chosen from gold, palladium, ruthenium, osmium, iron, cobalt, nickel, copper, zinc, silver, chromium, manganese, titanium, niobium, scandium, vanadium, yttrium, zirconium, molybdenum, tantalum, tungsten, technetium, cadmium, hafnium, rhenium, less than 5 wt. % of iridium, less than 5 wt. % of rhodium, greater than 20 wt. % iridium, greater than 20 wt. % rhodium, and a combination thereof, relative to the total weight of the…
NSTRUMENT COMPONENT ORGANIZER
Granted: January 12, 2023
Application Number:
20230011549
In some examples, an organizer may include a plurality of inserts. At least one insert of the plurality of inserts may include at least a front panel and an opposite back panel that form the at least one insert, and at least one instrument component disposed hi the at least one insert. The organizer may further include a binding mechanism that attaches the plurality of inserts.
NSTRUMENT COMPONENT ORGANIZER
Granted: January 12, 2023
Application Number:
20230011549
In some examples, an organizer may include a plurality of inserts. At least one insert of the plurality of inserts may include at least a front panel and an opposite back panel that form the at least one insert, and at least one instrument component disposed hi the at least one insert. The organizer may further include a binding mechanism that attaches the plurality of inserts.
METHODS, COMPOSITIONS, AND KITS FOR HIGH-THROUGHPUT RELEASE, LABELING, AND ANALYSIS OF O-GLYCANS PRESENT ON A GLYCOCONJUGATE
Granted: December 29, 2022
Application Number:
20220412985
The present disclosure provides methods, compositions, and kits for the rapid release, labeling, and detection of O-glycans present on a glycoconjugate, such as a glycoprotein, glycopeptide, peptidoglycan, or proteoglycan of interest. The compositions and methods allow the released O-glycans to be subjected to high-throughput analysis.
OPTIMIZED COORDINATION AND SCHEDULING OF USE OF EQUIPMENT AND RESOURCES WITHIN WORK ENVIRONMENT
Granted: November 24, 2022
Application Number:
20220374816
Novel tools and techniques are provided for implementing optimized scheduling of tasks involving equipment used by multiple individuals. In various embodiments, a computing system might receive, from a first user, a first request to use first equipment that is disposed in a work environment, the first request comprising information regarding a first task to be performed using the first equipment. The computing system might determine a core processing time during which the requested first…
DEEP LEARNING BASED INSTANCE SEGMENTATION VIA MULTIPLE REGRESSION LAYERS
Granted: November 17, 2022
Application Number:
20220366564
Novel tools and techniques are provided for implementing digital microscopy imaging using deep learning-based segmentation and/or implementing instance segmentation based on partial annotations. In various embodiments, a computing system might receive first and second images, the first image comprising a field of view of a biological sample, while the second image comprises labeling of objects of interest in the biological sample. The computing system might encode, using an encoder, the…
COUPLED-AMPLIFIER MULTI-FREQUENCY CIRCUIT TOPOLOGIES APPLICABLE TO MASS SPECTROMETER RADIO-FREQUENCY DRIVE SYSTEMS
Granted: November 10, 2022
Application Number:
20220360286
A circuit and method for providing high-voltage radio-frequency (RF) energy to an instrument at multiple frequencies includes a plurality of inputs each configured to receive an RF voltage signal oscillating at a corresponding frequency, and a step-up circuit for generating magnified RF voltage signals based on the received RF voltage signals. The step-up circuit includes an LC network operable to isolate the RF voltage signals at the plurality inputs from one another while preserving a…
METHOD AND SYSTEM FOR IMPLEMENTING AUGMENTED REALITY (AR)-BASED ASSISTANCE WITHIN WORK ENVIRONMENT
Granted: November 3, 2022
Application Number:
20220351475
Novel tools and techniques are provided for implementing augmented reality (AR)-based assistance within a work environment. In various embodiments, a computing system might receive, from a camera having a field of view of a work environment, first images of at least part of the work environment, the first images overlapping with a field of view of a user wearing an AR headset; might analyze the received first images to identify objects; might query a database(s) to determine a task…
HIGH THROUGHPUT, FLUORESCENCE-BASED ESTIMATION OF MONOCONAL ANTIBODY AGGREGATION WITH DISODIUM 3,3'-{[(E)-1,2-DIPHENYL-1,2-ETHENEDIYL]BIS(4,1-PHENYLENEOXY)}DI (1-PROPANESULFONATE) DYE FOR SUPERIOR SENSITIVITY AND SPECIFICITY
Granted: October 20, 2022
Application Number:
20220334125
The disclosure teaches a high-throughput, fluorescence-based assay for rapid, semi-quantitative estimation of high-molecular weight aggregation in mAb samples. The method rapidly estimates mAb aggregation.
SOFTWARE LICENSING MANAGEMENT AND AUTHENTICATION
Granted: October 6, 2022
Application Number:
20220318345
Novel tools and techniques are provided for implementing software licensing management and authentication. In various examples, a computing system might receive a request for an unlock code for a requested service from a user using a client device on which a first software is executed, the request comprising a generated unique identifier associated with the requested service and/or the first software. The generated unique identifier comprises licensing information associated with the…
MULTI-DEVICE REMOVAL AND INSTALLATION TOOL
Granted: September 22, 2022
Application Number:
20220301842
In some examples, a multi-device removal and installation tool may include a device removal tool including catch members engageable with an engagement face of a device to attach, upon engagement of the catch members with the engagement face, the device removal tool to the device. The catch members may engage the engagement face with a removal force that is sufficient to remove, upon engagement of the catch members with the engagement face, the device from an instrument. The multi-device…
VERSATILE TUBE-FREE JET FOR GAS CHROMATOGRAPHY DETECTOR
Granted: April 28, 2022
Application Number:
20220128518
A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
Gas Leak Detector Cartridge
Granted: March 31, 2022
Application Number:
20220099518
A gas leak detector cartridge includes a cartridge housing that is removably installed in a handheld device. The cartridge housing includes a sensor that detects a presence of a contaminant in a sample gas and is connected to a printed circuit board. The cartridge housing also includes a pump positioned in a manifold and introduces a sample gas to the sensor. The sensor is at least partially inserted into the manifold that includes the pump.
METHOD OF PRODUCING ETCHED NON-POROUS PARTICLES
Granted: December 9, 2021
Application Number:
20210380421
There is disclosed a method of producing etched non-porous particles. The method includes, in some examples, coating a non-porous particle with a hydrophilic polymer and treating the coated particle with acid or base. Also provided is etched non-porous particles capable of separating a variety of analytes, including biomolecules.
Solutions of Quaternary and Tertiary Ammonium Cation Detergents to Denature Proteins, and Kits for Making Them
Granted: December 2, 2021
Application Number:
20210371454
Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation. Ammonium cation detergents with sulfate or sulfonate anions are particularly useful.
Kits for Using Bispyridines to Improve Labeling of Nucleophiles
Granted: October 28, 2021
Application Number:
20210333269
Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.
Use of Mild Electrophiles to Reduce Artifacts in Analyzing Glycans Released from Glycoproteins or Glycopeptides
Granted: August 26, 2021
Application Number:
20210263043
The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or gly-copeptides.
METHODS FOR LABELING AMINE-CONTAINING COMPOUNDS
Granted: July 22, 2021
Application Number:
20210223253
The invention relates to an activated form of procaine, and the use of the activated procaine, or salts or solvates thereof, to label amine-containing compounds. In some embodiments, the amine-containing compound is an N-glycan.
