Method for Finding Species Peaks in Mass Spectrometry
Granted: August 22, 2019
Application Number:
20190259592
A method for operating a data processing system to find peaks in a mass spectrum that includes an ordered set of measurements of the abundances of species as a function of the mass/charge ratio of the species is disclosed. The method includes selecting a candidate blob that has a plurality of blob peaks from the mass spectrum. The data processing system selects a candidate blob peak for characterization. The candidate blob peak is approximated by a first species peak using a species peak…
Full Field Visual-Mid-Infrared Imaging System
Granted: August 1, 2019
Application Number:
20190238763
An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images.…
Experimental Chamber with Computer-Controlled Display Wall
Granted: January 3, 2019
Application Number:
20190004601
An environmental chamber having an interior compartment, an augmented display, and a controller is disclosed. The interior compartment is adapted for isolating an experimental setup from an environment external to the interior compartment. The augmented display is positioned to allow a user in the external environment to view the interior compartment and an image generated on the augmented display. The controller generates the image. The image includes information about a component…
Three-Dimensional Infrared Imaging of Surfaces Utilizing Laser Displacement Sensor
Granted: January 3, 2019
Application Number:
20190004300
A scanning apparatus having a stage adapted to hold a specimen to be imaged and to move the specimen in a first direction, and a light source that includes a tunable laser that generates a light beam having an illumination wavelength that varies as a function of an input signal is disclosed. The apparatus includes an imaging system having a scanning assembly that includes a focusing lens that focuses the light beam to a measurement point on the specimen, a first mirror that moves in a…
Full Field Visual-Mid-Infrared Imaging System
Granted: September 13, 2018
Application Number:
20180262699
An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images.…
Method for Unsupervised Stain Separation in Pathological Whole Slide Images
Granted: May 24, 2018
Application Number:
20180144464
A method of operating a data processing system to automatically process a color digital image of a specimen that has been stained with a first dye and a second different dye is disclosed. The method includes receiving a color image that includes a plurality of pixels, each pixel being characterized by a pixel vector having components determined by the intensity of light in each of a corresponding number of wavelength bands. A plurality of pixel vectors of the image are transformed to a…
Chemically Modified Guide RNAs for CRISPR/CAS-Mediated Gene Regulation
Granted: May 3, 2018
Application Number:
20180119140
Provided herein are methods for inducing CRISPR/Cas-based gene regulation (e.g., genome editing or gene expression) of a target nucleic acid (e.g., target DNA or target RNA) in a cell. The methods include using modified single guide RNAs (sgRNAs) that enhance gene regulation of the target nucleic acid in a primary cell for use in ex vivo therapy or in a cell in a subject for use in in vivo therapy. Additionally, provided herein are methods for preventing or treating a genetic disease in…
System and Method for Facilitating Manual Sorting of Objects
Granted: February 22, 2018
Application Number:
20180050370
An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the display surface corresponding to one of the objects to be illuminated based on the identification information and indicates a location to which the illuminated…
TEMPORARY STORAGE OF SAMPLE PORTIONS FOR ARTEFACT-PREVENTING FLUID PROCESSING
Granted: August 3, 2017
Application Number:
20170219540
In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one…
SECONDARY STAGE FLUID SEPARATION DEVICE DETACHABLY CONNECTABLE WITH PRIMARY STAGE FLUID SEPARATION DEVICE
Granted: May 11, 2017
Application Number:
20170131244
A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device is fluidically supplyable to the secondary stage sample separation device via the fluidic interface for further separation, wherein the secondary…
Apparatus and Method for Three-Dimensional Infrared Imaging of Surfaces
Granted: March 23, 2017
Application Number:
20170085810
A scanner and method for using the same are disclosed. The scanner includes a stage, a MIR light source, an imaging system, and a controller. The stage is adapted to hold a specimen to be imaged and to move the specimen in a first direction and in a second direction that is orthogonal to the lateral direction. The imaging system forms an image plane of the specimen when the stage is positioned at a second direction distance, z, from a known point in the imaging system. The imaging system…
Infrared Spectrometer and Scanner Utilizing Attenuated Total Reflection
Granted: March 23, 2017
Application Number:
20170082538
A scanner and an attenuated total reflection (ATR) objective for use in such scanners are disclosed The ATR objective includes first and second optical elements and an input port. The input port receives an input collimated light beam that is focused to a point on a planar face of the first optical element by the second optical element such that substantially all of that portion is reflected by the planar face and no portion of the input beam strikes the planar face at an angle greater…
High Dynamic Range Infrared Imaging Spectroscopy
Granted: March 23, 2017
Application Number:
20170082490
An imaging scanner and a method for using the same are disclosed. The scanner includes a variable attenuator adapted to receive a light beam generated by a MIR laser and that generates an attenuated light beam therefrom characterized by an attenuation level. The scanner includes an optical assembly that focuses the attenuated light beam to a point on a specimen. A light detector measures an intensity of light leaving the point on the specimen, the light detector being characterized by a…
Immobilized Transposase Complexes For DNA Fragmentation And Tagging
Granted: March 2, 2017
Application Number:
20170058326
The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting DNA. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. Purification is accomplished using a specific binding pair, in which one member of the pair is bound to an oligonucleotide adapter of the complex and the other member of the…
Quantum Cascade Laser with Serially Configured Gain Sections
Granted: February 2, 2017
Application Number:
20170033532
An apparatus that includes a gain chip assembly, an external cavity, and a controller is disclosed. The gain chip assembly includes first and second gain chips that are coupled optically such that light travels serially between the first gain chip and the second gain chip, each gain chip is electrically biased. The electrical bias of the first gain chip is independent of the electrical bias of the second gain chip. The external cavity has a tunable wavelength selective filter that is…
Light Source with Controllable Linear Polarization
Granted: January 5, 2017
Application Number:
20170003170
A light source having first and second wire-grid polarizers and a laser that emits a beam of linearly polarized light that is characterized by a propagation direction is disclosed. The first wire-grid polarization filter is characterized by a first linear polarization pass direction and a first actuator for causing the first linear polarization pass direction to rotate relative to the beam of linearly polarized light. The second wire-grid polarization filter is characterized by a second…
Infrared Imaging System with Automatic Referencing
Granted: January 5, 2017
Application Number:
20170003166
A method and apparatus for obtaining reference samples during the generation of a mid-infrared (MW) image without requiring that the sample being imaged be removed is disclosed. A tunable MIR laser generates a light beam that is focused onto a specimen on a specimen stage that moves the specimen in a first direction. An optical assembly includes a scanning assembly having a focusing lens and a mirror that moves in a second direction, different from the first direction, relative to the…
Full Field Visual-Mid-Infrared Imaging System
Granted: December 22, 2016
Application Number:
20160373663
An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images.…
Mutant Reverse Transcriptase and Methods of Use
Granted: November 24, 2016
Application Number:
20160340657
The invention relates to the generation and characterization of stable MMLV reverse transcriptase mutants. The invention also discloses methods of using stable MMLV reverse transcriptase mutants.
System and Method for Facilitating Manual Sorting of Objects
Granted: April 7, 2016
Application Number:
20160096200
An apparatus that facilitates the manual sorting of objects is disclosed. The apparatus includes a display surface having a surface that can be selectively illuminated and that is adapted for receiving the objects. An identification reader reads identification information stored on the objects. A controller causes an area on the display surface corresponding to one of the objects to be illuminated based on the identification information and indicates a location to which the illuminated…
