SYSTEM FOR PERFORMING OPTICAL SPECTROSCOPY INCLUDING INTERFEROMETER
Granted: March 5, 2015
Application Number:
20150062586
A system for performing optical spectroscopy measurements includes a light source for generating an input optical beam and an interferometer. The interferometer includes a beam splitter that splits the input optical beam into first and second light beams; a first light path that directs the first light beam through a sample containing an analyte to a first output port; and a second light path that directs the second light beam to the first output port. At least one of the first and…
ION DEFLECTION IN TIME-OF-FLIGHT MASS SPECTROMETRY
Granted: March 5, 2015
Application Number:
20150060656
A time-of-flight mass spectrometry (TOF MS) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor. The deflector deflects ions away from a main flight path such that the defected ions are not detected.
PLASMA-BASED PHOTON SOURCE, ION SOURCE, AND RELATED SYSTEMS AND METHODS
Granted: January 29, 2015
Application Number:
20150028222
A photon source includes a plasma source for generating plasma and a photon guide through which the plasma travels. The photon guide includes an inner surface configured for reflecting photons emitted from the plasma. As the plasma travels through the photon guide, plasma electrons and ions recombine at the inner surface, whereby the predominant species emitted from an outlet of the photon guide are the photons and neutral particles, with few or no plasma electrons and ions being…
State Space System Simulator Utilizing Bi-quadratic Blocks to Simulate Lightly Damped Resonances
Granted: January 1, 2015
Application Number:
20150006133
A method for operating a data processing system to simulate a physical system is disclosed. The physical system receives a time-varying input and generates a time-varying output. A model of the physical system is provided. The model depends on values of the time-varying input and an internal state in the physical system, the internal state is not directly measurable. The model includes a bi-quad component that models a resonance or anti-resonance of the physical system. For each of a…
TWO DIMENSIONAL NANOFLUIDIC CCD ARRAYS FOR MANIPULATION OF CHARGED MOLECULES IN SOLUTION
Granted: January 1, 2015
Application Number:
20150001084
The invention generally relates to methods and apparatus for manipulation of charged molecules in solution. More particularly, the invention provides nanofluidic CCD arrays that are capable of manipulate one or a group of molecules on an individual bases such that they undergo controlled physical and/or chemical movements and/or transformations.
Fluidic Chip with Displacable Patterned Layer for Detecting Fluid Pressure
Granted: January 1, 2015
Application Number:
20150000416
A fluidic chip device configured for processing a fluid, wherein the fluidic chip device comprises a plurality of layers laminated to one another, wherein at least a part of the layers comprises a patterned section of an alternating sequence of bars and fluidic channels for conducting the fluid under pressure, the patterned section being configured for being displaceable in response to the pressure, and a pressure detector responding to the displacement of the patterned section by…
Software Defined Microscope
Granted: December 18, 2014
Application Number:
20140368904
A microscope having a first illumination spatial light modulator (SLM) that receives light of a first wavelength from an illumination source and processes that light in a manner that transfers light into an objective lens through a dichroic reflector that passes light of the first wavelength is disclosed. The microscope includes an imaging system that receives light from the objective lens and forms an image on a camera, and a controller having a graphical user input that displays the…
HPLC SAMPLE INTRODUCTION WITH BYPASS CHANNEL
Granted: December 18, 2014
Application Number:
20140366739
A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher…
NUCLEIC ACID ENRICHMENT USING CAS9
Granted: December 4, 2014
Application Number:
20140356867
A method of enriching for a fragment of a genome, as well as corresponding compositions and kits, are provided. In certain embodiments, the method comprises: (a) contacting a sample comprising fragmented DNA with a Cas9-gRNA complex comprising mutant Cas9 protein that has inactivated nuclease activity and a Cas9-associated guide RNA that is complementary to a site in the DNA, to produce a Cas9-fragment complex that comprises a fragment of the fragmented DNA; and (b) isolating the…
METHOD FOR FRAGMENTING GENOMIC DNA USING CAS9
Granted: December 4, 2014
Application Number:
20140357523
A method for fragmenting a genome is provided. In certain embodiments, the method comprises: (a) combining a genomic sample containing genomic DNA with a plurality of Cas9-gRNA complexes, wherein the Cas9-gRNA complexes comprise a Cas9 protein and a set of at least 10 Cas9-associated guide RNAs that are complementary to different, pre-defined, sites in a genome, to produce a reaction mixture; and (b) incubating the reaction mixture to produce at least 5 fragments of the genomic DNA. Also…
Integrated Tool for Compliance Testing
Granted: October 9, 2014
Application Number:
20140303922
A method for operating a data processing system to perform compliance testing of an instrument system is disclosed. The instrument system includes an underlying instrument and a computerized data system (CDS) that controls the underlying instrument. The method includes causing data indicative of a measurement made on a test sample by the underlying instrument to be received by the data processing system. The data processing system then performs data reduction computations on the received…
Angular Synchronization of Stationary and Orbiting Plate Scroll Blades in a Scroll Pump Using a Metallic Bellows
Granted: October 9, 2014
Application Number:
20140301879
Parts of a pump head of a scroll pump facilitate an assembly process in which the stationary and orbiting scroll blades of the pump are angularly aligned or synchronized with one another. A metallic bellows of the pump head provides a primary means of synchronizing the stationary and orbiting scroll blades. The assembly process may be carried out using a fixture configured to be mountable to an assemblage including the bellows and the orbiting plate scroll. The fixture has a reference…
Thermal/Noise Management in a Scroll Pump
Granted: October 2, 2014
Application Number:
20140294638
The speed of a cooling fan of a scroll pump is controlled such that fan-generated noise can be kept low. The scroll pump includes a pump head, a pump motor, the fan, a controller and one or more sensors. The pump head includes a plate scroll set in which a tip seal is provided to create a seal between the blade and the opposing plates of the plate scrolls of the set. The speed of the fan is cycled by the controller, and the power draw on the pump motor as a result is checked. These…
Thermal/Noise Management in a Scroll Pump
Granted: October 2, 2014
Application Number:
20140294623
The main sources of heat in a scroll pump are cooled efficiently by a single cooling fan so that noise and, in particular, fan-generated noise, can be kept low. The scroll pump includes a pump head assembly, a pump motor, a cooling fan that produces a cooling air flow in the pump, a cowling in which the pump head assembly, pump motor and cooling fan are housed and juxtaposed with one another in an axial direction of the pump, and a shroud disposed within the cowling and extending around…
VACUUM FIRED AND BRAZED ION PUMP ELEMENT
Granted: October 2, 2014
Application Number:
20140292186
A Vacuum Fired and Brazed (“VFB”) anode array element for use in an ion pump is described. The VFB anode array element includes a first VFB conduit anode element and second VFB conduit anode element, wherein the second VFB conduit anode element is adjacent the first VFB conduit anode element. The first VFB conduit anode element is vacuum brazed together with second VFB conduit anode element.
Test System for Improving Throughout or Maintenance Properties of Semiconductor Testing
Granted: September 18, 2014
Application Number:
20140266282
A semiconductor test system includes test head pins; per-pin resources which are connectable to the test head pins on a one-to-one basis; shared resources, each of which is connectable to one of the test head pins; a tester controller for controlling the per-pin resources and the shared resources; and a tabular-form test plan including: a first column for specifying a measurement function that uses at least one of the per-pin resources and the shared resources; and at least one second…
Method for Creating a User Interface
Granted: September 18, 2014
Application Number:
20140282133
A method of operating a data processing system having a control screen to provide control of a program is disclosed. First and second program graphical user interfaces (GUIs) and a runtime library are provided. The first program GUI includes a first GUI description and a first method for operating on data input to or data output from that the first program GUI. The second program GUI includes a second GUI description and a second method for operating on data input to or data output from…
MODULAR PUMP PLATFORM
Granted: September 18, 2014
Application Number:
20140271233
A modular pump platform includes a pump head module, a pump motor module, an electronics module and a separable tray. The pump motor module includes a pump motor having a rotary output removably coupled to a crank shaft of the pump head, the pump motor being one of multiple types of pump motors, and the pump motor module being detachably connected to the pump head module. The electronics module includes an electronic control circuit configured control operation of the pump motor, the…
Pump Testing for Predicting Lifetime and Wear Conditions
Granted: September 18, 2014
Application Number:
20140271106
System and method for testing a pump. The testing of the pump includes determining a Mechanical Power Index (MPI) for the pump. The MPI is determined by operating the pump at operating speed for a minimum operating interval. When the pump is stopped under normal operation by the application, the pump speed is continuously monitored. The time when the pump speed decreases to an initial speed close to the operating speed is read as an initial time. When the pump speed decreases to a final…
ADJUSTABLE DIRECTIONAL COUPLER CIRCUIT
Granted: September 18, 2014
Application Number:
20140266499
An adjustable directional coupler circuit includes a directional coupler and a correction circuit. The directional coupler includes a first port for receiving an input signal; a second port for outputting the input signal to a load; a third port for outputting a first coupled signal including a desired first coupled signal proportional to forward power of the input signal and an extraneous first coupled signal proportional to reverse power of a reflected signal; and a fourth port for…
