Waveguide-based apparatus for exciting and sustaining a plasma
Granted: May 17, 2016
Patent Number:
9345121
An apparatus includes an electromagnetic which supports propagation of an electromagnetic wave in a first direction between a first end thereof and a second end thereof, and an electromagnetic-field shaping structure within the electromagnetic waveguide. The electromagnetic-field shaping structure defines a channel extending from a first aperture in a first wall of the apparatus to a second aperture in a second, opposite, wall. The channel has an axis extending in a second direction…
Methods and apparatus for increased ion throughput in tandem mass spectrometers
Granted: May 17, 2016
Patent Number:
9343281
In a tandem mass spectrometry system, a first mass analyzer filters parent ions using a wide mass passband with a narrow rejection notch defined according to a modulation format. A wide mass range of parent ions is transmitted to an ion fragmentation device. Daughter ions produced thereby are transmitted to a second mass analyzer to produce a daughter ion mass spectrum. The modulation of the measured daughter ion mass spectrum, when correlated with the passband modulation of the first…
System for performing optical spectroscopy including interferometer
Granted: May 17, 2016
Patent Number:
9341516
A system for performing optical spectroscopy measurements includes a light source for generating an input optical beam and an interferometer. The interferometer includes a beam splitter that splits the input optical beam into first and second light beams; a first light path that directs the first light beam through a sample containing an analyte to a first output port; and a second light path that directs the second light beam to the first output port. At least one of the first and…
Scroll vacuum pump and method of maintenance including replacing a tip seal of a scroll vacuum pump
Granted: May 17, 2016
Patent Number:
9341186
A scroll pump has a tip seal between an axial end of the scroll blade of one of stationary and orbiting plate scrolls of the pump and the plate of the other of the stationary plate and orbiting plate scrolls. The scroll pump may have a ballast gas supply system and use the operation of the ballast gas supply system to assess the condition of the tip seal. Alternatively, the scroll pump may have two pressure sensors that sense pressure at two locations spaced along a compression mechanism…
Fluidic valve with selectively switchable storage paths
Granted: May 10, 2016
Patent Number:
9335309
A sample separation apparatus includes a fluidic valve including a first inlet fluidically coupled to one of a first fluid drive and a second fluid drive, and a second inlet fluidically coupled to the other of the first fluid drive and the second fluid drive. The fluidic valve includes at least two different sets of storage paths, wherein each set of storage paths comprises a first storage path. The first storage path of a first set of said at least two sets of storage paths has a first…
Spectrographic system utilizing a chirped, pulsed optical source
Granted: May 10, 2016
Patent Number:
9335265
An apparatus and method for measuring the attenuation and dispersion introduced by a sample into an optical signal are disclosed. The apparatus includes a chirped light source, a beam splitter and an optical detector. The beam splitter splits the optical signal generated by the light source into a reference optical signal and a sample optical signal. The sample and reference optical signals are mixed on the detector after the sample optical signal has traversed an experimental sample…
Plasma generation device with microstrip resonator
Granted: May 3, 2016
Patent Number:
9330889
A plasma generation device, a system including a plasma generation device, and a method of generating plasma and vacuum UV (VUV) photons are described. In a representative embodiment, plasma generation device, includes: a substrate having a first surface and a second surface; a resonant ring-shaped structure disposed over the first surface of the substrate, the resonant ring-shaped structure having dimensions selected to support at least one standing wave having more than one electric…
Angular synchronization of stationary and orbiting plate scroll blades in a scroll pump using a metallic bellows
Granted: May 3, 2016
Patent Number:
9328730
Parts of a pump head of a scroll pump facilitate an assembly process in which the stationary and orbiting scroll blades of the pump are angularly aligned or synchronized with one another. A metallic bellows of the pump head provides a primary means of synchronizing the stationary and orbiting scroll blades. The assembly process may be carried out using a fixture configured to be mountable to an assemblage including the bellows and the orbiting plate scroll. The fixture has a reference…
Shear valve with silicon carbide member
Granted: April 19, 2016
Patent Number:
9316324
A shear valve, for use in a high performance liquid chromatography system, comprises a first shear valve member and a second shear valve member. At least one of the first and second shear valve members is adapted to be moved with respect to the other. One of the first and second shear valve members comprises a plurality of ports, and the other comprises at least one fluid path for fluidly coupling respective ones of the ports in dependency on a relative movement position of the first and…
Protein analysis using a polymethine marker dye
Granted: March 29, 2016
Patent Number:
9297807
A kit for optically detecting proteins, in particular lipoproteins, in a sample, the kit comprising: a chip for performing a separation of the proteins, in particular of the lipoproteins, wherein the chip comprises at least one well for receiving the sample, and a separation channel coupled to the at least one well and being adapted for separating different compounds and a marker dye which contains a polymethine of the general formula (I) wherein Z is a substituted derivative of…
Nucleic acid probes for analysis of small RNAs and other polynucleotides
Granted: March 29, 2016
Patent Number:
9297036
The invention provides a nucleic acid probe for detecting a polynucleotide. The probe contains a region that base-pairs with a polynucleotide to form a duplex and a Tm enhancement domain that increases the stability of the duplex. The Tm enhancement domain may contain a nucleotide clamp and/or a hairpin structure, for example. Also provided is an array of subject nucleic acid probes bound to a surface of the solid support. Methods of using a subject probe to assess polynucleotides, e.g.,…
Analyte detection assays
Granted: March 22, 2016
Patent Number:
9291627
The present invention provides methods, kits and compositions for the detection of an analyte. In the methods of the invention, a binding molecule coupled to a first polymerase is incubated with a modified polynucleotide template to form a copy of the modified polynucleotide template without any modified nucleotides. The unmodified copy is detected in a second amplification/primer extension reaction using a second polymerase that is unable to amplify the modified polynucleotide template.…
Valve for use in high-performance liquid chromatography having a spherical seat with beveled outer faces
Granted: March 22, 2016
Patent Number:
9291605
A valve for use in high-performance liquid chromatography has a spherical seat and a ball that, when it abuts against the seat, constrains a fluid from flowing through the valve and is capable of moving axially in order to allow the fluid to flow through the valve. The spherical seat has beveled outer faces in order that a force acting on the valve along the axial direction will generate a force acting on the ball. The inclination of the beveled outer face is such that a force acting on…
Systems and methods for producing chemical array layouts
Granted: March 15, 2016
Patent Number:
9286438
Systems and methods for using the same to obtain a chemical array layout are provided. Also provided are computer program products for executing the subject methods.
Superficially porous metal oxide particles, methods for making them, and separation devices using them
Granted: March 15, 2016
Patent Number:
9284456
Superficially porous hybrid particles include hybrid solid cores that each contain an inorganic material and an organic material; and porous hybrid outer shells each include the inorganic and organic materials and having ordered pores, wherein the ordered pores have a median pore size ranges from about 15 to about 1000 ? with a pore size distribution (one standard deviation) of no more than 50% of the median pore size and produce at least one X-ray diffraction peak between 0.01° and…
Ion processing utilizing segmented vacuum manifold
Granted: March 8, 2016
Patent Number:
9281173
An ion processing device includes electrically conductive vacuum manifold segments serially positioned and enclosing a volume along an axis. The segments are electrically isolated from each other and independently addressable by a voltage source. An ion optics device is positioned in the volume. A voltage differential between each manifold segment and the ion optics device is maintained below a maximum value by applying different voltages to respective manifold segments. The voltage…
Optical emission system including dichroic beam combiner
Granted: March 8, 2016
Patent Number:
9279722
An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and the second light via a second light path, reflects a portion the first light into an entrance aperture of a light detection and measurement apparatus, and transmits a portion of the second…
Time of flight mass spectrometer utilizing overlapping frames
Granted: March 1, 2016
Patent Number:
9275841
A time of flight (TOF) spectrometer and a method for operating the same is disclosed. The spectrometer includes an event extractor, a streaming processor, and a FIFO buffer. The event extractor generates a ion event record corresponding to each detected ion, the ion event record including an intensity of a plurality of aliases for that detected ion. The streaming processor includes a memory array that stores a TOF spectrum and a probability processor that provides a probability for each…
Protected monomer and method of final deprotection for RNA synthesis
Granted: March 1, 2016
Patent Number:
9273086
A method of deprotecting a solid support bound polynucleotide includes the step of contacting the polynucleotide with a composition comprising a diamine under conditions sufficient to deprotect the 2?-protected ribonucleotide residue. The solid support bound polynucleotide has at least one 2?-protected ribonucleotide residue, which has the following structure: wherein BP is a protected or unprotected heterocycle; R12 is a protecting group selected from a hydrocarbyl, a substituted…
Ferrule chuck with surface micro-grip
Granted: February 23, 2016
Patent Number:
9267630
A fitting for coupling a capillary to another component of a fluidic device is disclosed. The fitting includes a ferrule configured for enclosing a front part of the capillary and for contributing to a fluidic sealing between the fitting and the other component; a ferrule chuck configured for enclosing a back part of the capillary; and a housing configured for accommodating at least a part of the ferrule chuck and for pushing the ferrule chuck against the ferrule.
