Identification and characterization of an anthocyanin mutant (ANT1) in tomato
Granted: April 25, 2006
Patent Number:
7034138
The present invention is directed to a novel plant phenotype, designated Anthocyanin 1 (ANT1), a nucleic acid sequence expressed in plants demonstrating the ANT1 phenotype and the corresponding amino acid sequence. Also provided are plant cells and plants that exhibit modified ANT1 expression.
Fuel pump control device
Granted: April 4, 2006
Patent Number:
7021294
To provide a fuel pump control device allowing a fuel pump having a small capacity to feed a sufficient amount of fuel to an internal combustion engine. During running of a vehicle at a low speed (for example, less than 2,0 km/hr), pulsed drive voltages are intermittently supplied to a fuel pump in accordance with each opening/closing of a thyristor on the basis of ignition pulses of the engine. In this way, the fuel pump repeats discharge operation at a relatively long cycle in…
RRP sequences and knockout mice and uses thereof
Granted: December 6, 2005
Patent Number:
6972179
RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
HADHs as modifiers of the p21 pathway and methods of use
Granted: August 9, 2005
Patent Number:
6927022
Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
Human RRP sequences and methods of use
Granted: August 2, 2005
Patent Number:
6924117
Rhomboid Related Proteins (RRPs), involved in the EGFR signaling pathway, are provided. Transgenic, nonhuman mammals containing a transgene encoding an RRP polypeptide or a gene effecting the expression of an RRP polypeptide, along with methods of modulating the interaction of RRP proteins with their pathway members, and methods of screening for agents that modulate the interaction of an RRP polypeptide with an RRP binding target, such as RRP-specific antibodies and small molecules…
Multi-well apparatus
Granted: February 8, 2005
Patent Number:
6852290
A multi-well assembly according to one embodiment comprises a multi-well block and a guide plate. The multi-well block defines a plurality of wells, with each well having a fluid-impermeable bottom surface. The guide plate defines a plurality of fluid passageways corresponding to the wells of the multi-well block. The guide plate is configured such that, whenever the guide plate is registered with the multi-well block, fluid communication is established between each well and an…
Animal models and methods for analysis of lipid metabolism and screening of pharmaceutical and pesticidal agents that modulate lipid metabolism
Granted: August 24, 2004
Patent Number:
6781028
Drosophila melanogaster and C. elegans that have been genetically modified to express or mis-express proteins involved in the sterol regulatory element binding protein (SREBP) pathway are described. These genetically modified animal models have identifiable phenotypes that make them useful in assays for studying lipid metabolism, other genes implicated in lipid metabolism, and compounds capable of modulating lipid metabolism pathways. Methods for studying lipid metabolism in living…
Insect p53 tumor suppressor genes and proteins
Granted: July 13, 2004
Patent Number:
6762291
A family of p53 tumor suppressor nucleic acid and protein isolated from several insect species is described. The p53 nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in p53 expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with p53…
CTR1 homologue from melon
Granted: April 13, 2004
Patent Number:
6720476
The invention relates to the nucleic acid and amino acid sequences for a melon constitutive triple response (CTR1) homologue, called mCTR, vectors, cells and transgenic plants which comprise the coding sequence for mCTR or a biologically active fragment thereof and methods of producing transgenic plants which express mCTR or a biologically active fragment thereof.
Drosophila sequences
Granted: March 9, 2004
Patent Number:
6703491
The present invention relates to Drosophila genes and methods for their use. The invention provides nucleotide sequences of Drosophila genes, amino acid sequences of the encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of proteins which comprise one or more domains of a Drosophila protein. Antibodies to Drosophila proteins, and derivatives and analogs thereof, are also provided. Also…
Robotic apparatus and methods for maintaining stocks of small organisms
Granted: February 10, 2004
Patent Number:
6688255
According to one embodiment, a robotic apparatus for maintaining a collection of stocks of small organisms, such as fruit flies, is capable of performing various tasks, including automatically transferring live flies from a donor container to a recipient container, such as for the purpose of feeding the flies. The apparatus includes an anesthetizing mechanism configured to automatically introduce an anesthetic, such as gaseous CO2, into a donor container of live flies to temporarily…
Melon promoters for expression of transgenes in plants
Granted: November 4, 2003
Patent Number:
6642438
The present invention is directed to a melon actin promoter capable of providing expression of heterologous genes, and nucleic acid constructs, vectors, transformation methods, transgenic plant cells, and transgenic plants comprising said promoter.
Methods of screening for agents that modulate the interaction of human ECT2 polypeptide with an ECT2 binding target
Granted: October 7, 2003
Patent Number:
6630297
Human Ect2 polypeptide, fragments and derivatives, along with vectors and host cells for expression and production of Ect2 polypeptide are provided. Various methods of screening for agents that modulate interaction of Ect2 with an Ect2 binding agent, including high throughput methods, are also provided.
Nucleic acids and proteins of C. elegans insulin-like genes and uses thereof
Granted: September 30, 2003
Patent Number:
6627746
The present invention relates to C. elegans insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of C. elegans insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like…
Invertebrate vascular endothelial growth factor receptor
Granted: July 29, 2003
Patent Number:
6599717
Vascular Endothelial Growth Factor Receptor (dmVEGFR) nucleic acids and proteins that have been isolated from Drosophila melanogaster are described. The dmVEGFR nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in dmVEGPR expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential therapeutics…
Semaphorin K1
Granted: June 24, 2003
Patent Number:
6583277
The invention provides methods and compositions relating to semaphorin K1 (sema K1) polypeptides which regulate cellular guidance and physiology, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed sema K1 encoding nucleic acids or purified from human cells. The invention provides isolated sema K1 hybridization probes and primers capable of specifically hybridizing with the disclosed sema K1 genes, sema K1-specific…
Drosophila homologues of genes and proteins implicated in cancer and methods of use
Granted: June 17, 2003
Patent Number:
6579701
Novel nucleic acids that are homologs of genes implicated in cancer are described that have been isolated from Drosophila melanogaster. These novel nucleic acids can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in novel gene expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics…
Development of resistance to raspberry bushy dwarf virus
Granted: April 15, 2003
Patent Number:
6548742
The present invention relates to isolated Raspberry Bushy Dwarf Virus (RBDV) nucleic acid sequences which encode RBDV coat and movement proteins or polypeptides and mutant or modified forms thereof. The invention further relates to heterologous nucleic acid constructs, vectors, transformation methods, plant cells and plants comprising such RBDV-encoding nucleic acids and methods for inducing resistance to RBDV by transforming plants with a nucleic acid construct comprising RBDV protein…
Methods for identifying anti-cancer drug targets
Granted: March 11, 2003
Patent Number:
6531644
Methods, transformation constructs, and transgenic animals for identifying anti-tumor agents and anti-tumor drug targets are described. The transformation constructs are used to generate transgenic animals that have altered expression of an oncogene or tumor suppressor gene in a target tissue that is dispensable for viability and reproduction. In some embodiments, the altered expression results in abnormal proliferation of the target tissue and normal proliferation in all other tissues.…
Universal markers of transgenesis
Granted: February 11, 2003
Patent Number:
6518481
The invention relates to methods, cells and nucleic acids for making transgenic animals. The methods generally comprise introducing into a genome of an animal a genetic construct comprising a transcriptional regulatory element operably linked to a heterologous marker gene encoding a marker, wherein the element drives expression of the marker across genera transgenic in the construct sufficient to visually detect the marker in photoreceptive cells or organs, and selecting for transgenesis…
