Method to Use Gene Expression to Determine Likelihood of Clinical Outcome of Renal Cancer
Granted: March 21, 2024
Application Number:
20240096451
The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
DNA Methylation and Mutational Analysis Methods for Bladder Cancer Surveillance
Granted: November 23, 2023
Application Number:
20230374604
The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
Method to Use Gene Expression to Determine Likelihood of Clinical Outcome of Renal Cancer
Granted: February 17, 2022
Application Number:
20220051755
The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
Gene Expression Profile Algorithm for Calculating a Recurrence Score for a Patient with Kidney Cancer
Granted: February 10, 2022
Application Number:
20220044760
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the…
Method to Use Gene Expression to Determine Likelihood of Clinical Outcome of Renal Cancer
Granted: June 3, 2021
Application Number:
20210166790
The present disclosure provides gene and gene sets, the expression of which is important in the classification and/or prognosis of cancer, in particular of renal cell carcinoma.
Gene Expression Profile Algorithm for Calculating a Recurrence Score for a Patient with Kidney Cancer
Granted: May 20, 2021
Application Number:
20210151122
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the…
METHODS TO PREDICT CLINICAL OUTCOME OF CANCER
Granted: March 4, 2021
Application Number:
20210062275
The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer…
Prediction of Likelihood of Cancer Recurrence
Granted: September 24, 2020
Application Number:
20200299781
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
METHOD OF PREDICTING BREAST CANCER PROGNOSIS
Granted: August 20, 2020
Application Number:
20200263257
The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
Method for Using Gene Expression to Determine Prognosis of Prostate Cancer
Granted: August 13, 2020
Application Number:
20200255911
Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
DNA Methylation and Mutational Analysis Methods for Bladder Cancer Surveillance
Granted: May 28, 2020
Application Number:
20200165686
The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.
Methods of Incorporation of Transcript Chromosomal Locus Information for Identification of Biomarkers of Disease Recurrence Risk
Granted: April 2, 2020
Application Number:
20200105367
The present invention provides methods for incorporating transcript chromosomal locus information for identification of biomarkers of disease recurrence risk.
Algorithms and Methods for Assessing Late Clinical Endpoints in Prostate Cancer
Granted: February 6, 2020
Application Number:
20200040400
The present disclosure relates to uses of a multiple gene-expression based Genomic Prostate Score™ (GPS™) algorithm for assessment of various clinical endpoints in prostate cancer patients, such as risks of clinical recurrence (CR), biochemical recurrence (BCR), distant metastasis (Mets), and prostate cancer death (PCD). In some embodiments, GPS result is determined for low and intermediate risk prostate cancer patients in order to assist in determining treatment strategies for those…
METHOD OF PREDICTING BREAST CANCER PROGNOSIS
Granted: August 22, 2019
Application Number:
20190256923
The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts, and are useful for predicting the likelihood of breast cancer recurrence in a breast cancer patient. The present invention also relates to a novel method of identifying intergenic sequences that correlate with a clinical outcome.
Method for Using Gene Expression to Determine Prognosis of Prostate Cancer
Granted: August 15, 2019
Application Number:
20190249260
Molecular assays that involve measurement of expression levels of prognostic biomarkers, or co-expressed biomarkers, from a biological sample obtained from a prostate cancer patient, and analysis of the measured expression levels to provide information concerning the likely prognosis for said patient, and likelihood that said patient will have a recurrence of prostate cancer, or to classify the tumor by likelihood of clinical outcome or TMPRSS2 fusion status, are provided herein.
METHODS TO PREDICT CLINICAL OUTCOME OF CANCER
Granted: August 8, 2019
Application Number:
20190241967
The present invention provides methods to determine the prognosis and appropriate treatment for patients diagnosed with cancer, based on the expression levels of one or more biomarkers. More particularly, the invention relates to the identification of genes, or sets of genes, able to distinguish breast cancer patients with a good clinical prognosis from those with a bad clinical prognosis. The invention further provides methods for providing a personalized genomics report for a cancer…
Gene Expression Profile Algorithm for Calculating a Recurrence Score for a Patient with Kidney Cancer
Granted: March 28, 2019
Application Number:
20190095575
The present invention provides algorithm-based molecular assays that involve measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The present invention also provides methods of obtaining a quantitative score for a patient with kidney cancer based on measurement of expression levels of genes from a biological sample obtained from a kidney cancer patient. The genes may be grouped into functional gene subsets for calculating the…
GENE EXPRESSION MARKERS FOR BREAST CANCER PROGNOSIS
Granted: August 16, 2018
Application Number:
20180230548
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
METHODS FOR DEPLETING RNA FROM NUCLEIC ACID SAMPLES
Granted: July 26, 2018
Application Number:
20180208968
The invention relates to methods of depleting RNA from a nucleic acid sample. The RNA may be any RNA, including, but not limited to, rRNA, tRNA, and mRNA. The method is useful for depleting RNA from a nucleic acid sample obtained from a fixed paraffin-embedded tissue (FPET) sample. The method may also be used to prepare cDNA, in particular, a cDNA library for further analysis or manipulation.
PREDICTION OF LIKELIHOOD OF CANCER RECURRENCE
Granted: February 22, 2018
Application Number:
20180051348
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of cancer, in particular of breast cancer.
