PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS
Granted: June 30, 2011
Application Number:
20110160458
The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
METHODS OF TREATING HBV AND HCV INFECTION
Granted: June 23, 2011
Application Number:
20110150836
This application relates to a purine derivative and pharmaceutical compositions which are useful for treating a hepatitis B viral infection or a hepatitis C viral infection.
SALTS OF HIV INHIBITOR COMPOUNDS
Granted: June 16, 2011
Application Number:
20110144050
The invention is related to salts of anti-viral compounds, compositions containing such salts, and therapeutic methods that include the administration of such salts, as well as to processes and intermediates useful for preparing such salts.
ANTIVIRAL COMPOUNDS
Granted: June 9, 2011
Application Number:
20110135599
The present application includes novel inhibitors of HCV, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
ANTIVIRAL COMPOUNDS
Granted: June 9, 2011
Application Number:
20110135604
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
A2B ADENOSINE RECEPTOR ANTAGONISTS
Granted: June 2, 2011
Application Number:
20110130362
Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
Methods to Manufacture 1,3-Dioxolane Nucleosides
Granted: June 2, 2011
Application Number:
20110130559
This application provides a process for preparing enantiomerically pure ?-D-dioxolane nucleosides. In particular, a new synthesis of (?)-DAPD, suitable for large scale development, is described. In one embodiment the invention provides a process for preparing a substantially pure ?-D- or ?-L-1,3-dioxolane nucleosides comprising a) preparing or obtaining an esterified 2,2-dialkoxy ethanol; b) cyclizing the esterified 2,2-dialkoxy ethanol with glycolic acid to obtain a 1,3-dioxolane…
2,4,6-TRISUBSTITUTED PYRIDO(3,2-d) PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS
Granted: May 26, 2011
Application Number:
20110123493
Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
INHALED FOSFOMYCIN/TOBRAMYCIN FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Granted: May 26, 2011
Application Number:
20110124589
The present invention provides the use of an aerosol formulation comprising fosfomycin and tobramycin in the treatment of patients with chronic obstructive pulmonary disease (COPD) who are experiencing or are at risk of experiencing acute exacerbations of COPD. Formulations for such use and methods of treating humans with COPD are also provided.
MODULATORS OF TOLL-LIKE RECEPTORS
Granted: May 26, 2011
Application Number:
20110124627
The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
MODULATORS OF TOLL-LIKE RECEPTORS
Granted: April 28, 2011
Application Number:
20110098248
The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
ANTIVIRAL PHOSPHINATE COMPOUNDS
Granted: April 7, 2011
Application Number:
20110081314
The invention is related to anti-viral phosphinate compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
ANTIVIRAL PHOSPHINATE COMPOUNDS
Granted: April 7, 2011
Application Number:
20110082112
The invention is related to a method of treating disorders associated with hepatitis C by administering to an individual a pharmaceutical composition which comprises a therapeutically effective amount of an anti-viral phosphinate compound.
Novel HIV reverse transcriptase inhibitors
Granted: March 31, 2011
Application Number:
20110076276
The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
2'-FLUORO SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT
Granted: March 24, 2011
Application Number:
20110070194
Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 2? position of the nucleoside sugar is substituted with halogen and carbon substitutents. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections caused by both wild type and…
PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS
Granted: March 17, 2011
Application Number:
20110065631
A process for the synthesis of bisfuran intermediates of formula (0) useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed. Furthermore disclosed is a HIV protease inhibitor of formula (IV) as well as various intermediates thereof.
IMIDAZOPYRIDINYL THIAZOLYL HISTONE DEACETYLASE INHIBITORS
Granted: March 3, 2011
Application Number:
20110052527
A compound of general Formula (I) having histone deacetylase (HDAC) and/or CDK inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.
INHIBITORS OF FLAVIVIRIDAE VIRUSES
Granted: January 27, 2011
Application Number:
20110020278
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
Granted: January 13, 2011
Application Number:
20110009410
The present invention relates to compounds of Formula (I): where in X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the…
THERAPEUTIC COMPOSITIONS AND THE USE THEREOF
Granted: January 13, 2011
Application Number:
20110009411
The invention includes methods, compositions, and kits useful for treating a viral infection by coadministering 6-(3-chloro-2-fluorobenzyl)-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid or a pharmaceutically acceptable salt thereof, with lopinavir or a pharmaceutically acceptable salt thereof.
