APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
Granted: August 8, 2013
Application Number:
20130203819
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, R, R1, R2 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD,…
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Granted: August 8, 2013
Application Number:
20130203747
Compounds of formula I: wherein a, R1, R2, R3, R4, R5 and R6 are defined herein, are useful as inhibitors of HIV replication.
NAPHT-2-YLACETIC ACID DERIVATIVES TO TREAT AIDS
Granted: August 8, 2013
Application Number:
20130203727
The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS or ARC symptoms in a mammal using compounds of formula (I).
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Granted: August 1, 2013
Application Number:
20130197231
Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
APOPTOSIS SIGNAL-REGULATING KINASE INHIBITOR
Granted: August 1, 2013
Application Number:
20130197037
The present invention relates to a compound of formula (I): The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.
SUBSTITUTED HETEROCYCLIC COMPOUNDS
Granted: August 1, 2013
Application Number:
20130197001
The present invention relates to compounds that are late sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (I): wherein R1, R2, R3, and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
Granted: July 25, 2013
Application Number:
20130190491
Compounds of formula I: wherein c, R2, R3, R4, R5, R6, R7 and R8 are defined herein, are useful as inhibitors of HIV replication.
FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
Granted: July 18, 2013
Application Number:
20130184255
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
ANTIVIRAL COMPOUNDS
Granted: July 11, 2013
Application Number:
20130177530
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
PROCESS FOR PREPARATION OF HIV PROTEASE INHIBITORS
Granted: July 4, 2013
Application Number:
20130172295
A process for the synthesis of bisfuran intermediates useful for preparing antiviral HIV protease inhibitor compounds is hereby disclosed
HETEROCYCLIC FLAVIVIRIDAE VIRUS INHIBITORS
Granted: July 4, 2013
Application Number:
20130171102
The invention is related to anti-viral compounds of formula (A) as defined in the claims, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well to processes and intermediates useful for preparing such compounds.
PYRAZOLO[1,5-A]PYRIMIDINES AS ANTIVIRAL AGENTS
Granted: June 27, 2013
Application Number:
20130164280
The invention provides compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections. The compounds and compositions are useful for treating Pneumovirinae virus infection including Human respiratory syncytial virus infections.
ANTIVIRAL COMPOUNDS
Granted: June 27, 2013
Application Number:
20130164260
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING GASTROINTESTINAL INFECTIONS AND DISORDERS
Granted: June 20, 2013
Application Number:
20130157973
Methods of treating gastrointestinal disorders, in a patient in need thereof, including disorders of the liver and pancreas, using an amount of an orally dosed TLR-7 compound in an amount sufficient to increase IFN in the gastrointestinal area, including the liver, but not significantly increasing systemic IFN.
ANTIVIRAL COMPOUNDS
Granted: June 20, 2013
Application Number:
20130156732
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
ANTIVIRAL COMPOUNDS
Granted: May 30, 2013
Application Number:
20130137877
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS
Granted: May 16, 2013
Application Number:
20130123311
The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
A2B ADENOSINE RECEPTOR ANTAGONISTS
Granted: May 16, 2013
Application Number:
20130123280
Disclosed are novel compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
PROCESS AND INTERMEDIATES FOR PREPARING INTEGRASE INHIBITORS
Granted: May 9, 2013
Application Number:
20130116437
The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
SUBSTITUTED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
Granted: April 25, 2013
Application Number:
20130102632
The present invention relates to sodium channel inhibitors of Formula (I): in which R1, R2, R3, R4, R5, X, Y, and Z are as defined herein, and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.
