Methods for treating filoviridae virus infections
Granted: June 30, 2020
Patent Number:
10695357
Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.
Substituted 3,4,5,6,8,10,14,14a-octahydro-2h-2,6-methanopyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazocines and methods for treating viral infections
Granted: June 23, 2020
Patent Number:
10689399
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Methods of treating feline coronavirus infections
Granted: June 16, 2020
Patent Number:
10682368
Provided are methods of treating feline Coronavirus infections using carbanucleoside compounds having a 1?-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl) substituent, or a pharmaceutically acceptable salt thereof. An exemplary compound is (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile.
Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
Granted: June 9, 2020
Patent Number:
10675296
The present disclosure provides a composition comprising Compound 1, or a pharmaceutically acceptable salt thereof, cyclodextrin, and, optionally, pH adjusting agents.
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
Granted: June 2, 2020
Patent Number:
10668064
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, Y1, Y2, or L are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Therapeutic compounds
Granted: May 19, 2020
Patent Number:
10654827
The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
Granted: May 12, 2020
Patent Number:
10646486
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A?, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Toll like receptor modulator compounds
Granted: May 5, 2020
Patent Number:
10640499
This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them. The toll-like receptor modulators of the present invention include compounds such as
Processes for preparing ASK1 inhibitors
Granted: March 31, 2020
Patent Number:
10604490
The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
Cot modulators and methods of use thereof
Granted: March 3, 2020
Patent Number:
10577352
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
Antibodies selective for cells presenting EGFR at high density
Granted: February 25, 2020
Patent Number:
10570211
Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
Quinazoline compounds
Granted: February 4, 2020
Patent Number:
10548898
Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
Therapeutic compositions for treatment of human immunodeficiency virus
Granted: February 4, 2020
Patent Number:
10548846
A solid oral dosage form is provided, comprising a compound of Formula I or a pharmaceutically acceptable salt thereof, tenofovir alafenamide or a pharmaceutically acceptable salt thereof, and emtricitabine or a pharmaceutically acceptable salt thereof.
Non-selective kinase inhibitors
Granted: January 14, 2020
Patent Number:
10532994
Disclosed herein are compounds, compositions, and methods for preventing and treating proliferative diseases associated with aberrant receptor tyrosine kinase (RTK) activity. The therapeutic indications described herein more specifically relate to the non-selective inhibition of RTKs associated with vascular and pulmonary disorders.
Synthesis of polycyclic-carbamoylpyridone compounds
Granted: December 31, 2019
Patent Number:
10519168
Methods of making compounds of Formula I are disclosed:
Processes for preparing ACC inhibitors and solid forms thereof
Granted: December 31, 2019
Patent Number:
10519165
The present disclosure provides solid forms, including a salt or co-crystal, of Compound I: which exhibits Acetyl-CoA carboxylase (“ACC”) inhibitory activity and may be useful in treating ACC mediated diseases. Also provided herein are processes or steps for the preparation of a Compound I and intermediates useful for the processes or steps described herein.
Solid forms of a toll-like receptor modulator
Granted: December 17, 2019
Patent Number:
10508117
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
Apoptosis signal-regulating kinase inhibitor
Granted: December 17, 2019
Patent Number:
10508100
The present invention relates to a compound of formula (I): The compound has apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis.
Thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-D]pyrimidines useful for treating respiratory syncitial virus infections
Granted: December 10, 2019
Patent Number:
10501476
Provided herein are formulations, methods and substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted thieno[3,2-d]pyrimidine, furo[3,2-d]pyrimidine, and pyrrolo[3,2-d]pyrimidine compounds.
Methods of treating liver fibrosis
Granted: December 3, 2019
Patent Number:
10495648
The present application provides methods of diagnosing, treating, and/or monitoring a liver disease or condition in a human.
