Process for preparing dronedarone and salts thereof
Granted: January 26, 2016
Patent Number:
9242953
The present disclosure relates to processes for preparing dronedarone or pharmaceutically acceptable salts thereof.
Pyrazolo[1,5-A]pyrimidines for antiviral treatment
Granted: January 19, 2016
Patent Number:
9238039
The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Antiviral compounds
Granted: January 12, 2016
Patent Number:
9233974
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Phosphatidylinositol 3-kinase inhibitors
Granted: December 29, 2015
Patent Number:
9221795
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (I), or pharmaceutically acceptable salts or isomers thereof, in which n, m, R1, R2, R4, and R3 are as defined herein. These compounds are useful for treatment of conditions mediated by one or more PI3K isoforms, such as PI3K?. The present disclosure further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts or isomers thereof, and…
Therapeutic compounds
Granted: December 29, 2015
Patent Number:
9220710
Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1?,2?:4,5]pyrazino[2,1-b][1,3]oxazepines and methods for treating viral infections
Granted: December 22, 2015
Patent Number:
9216996
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Fused heterocyclic compounds as ion channel modulators
Granted: November 24, 2015
Patent Number:
9193694
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Z1, Z2, Z3, Z4, X, Y, R2, R3 and R4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
Apoptosis signal-regulating kinase inhibitors
Granted: October 27, 2015
Patent Number:
9169243
The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ASK1), thus are thus useful in treating ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and…
Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
Granted: October 20, 2015
Patent Number:
9161934
The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
Methods of myocardial perfusion imaging
Granted: October 20, 2015
Patent Number:
9163057
The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.
Macrocyclic inhibitors of flaviviridae viruses
Granted: September 29, 2015
Patent Number:
9145441
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
Antiviral phosphonate analogs
Granted: September 22, 2015
Patent Number:
9139604
The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Modulators of pharmacokinetic properties of therapeutics
Granted: September 22, 2015
Patent Number:
9139541
The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.
FXR (NR1H4) binding and activity modulating compounds
Granted: September 22, 2015
Patent Number:
9139539
The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.
Modulators of toll-like receptors
Granted: September 8, 2015
Patent Number:
9127006
Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Compound and methods for treating long QT syndrome
Granted: September 8, 2015
Patent Number:
9126989
Described herein is a method of treating long QT syndrome by administration of an effective amount of a potent and selective late sodium ion channel blocker.
Methods of treating hypertrophic cardiomyopathy
Granted: September 8, 2015
Patent Number:
9125916
The present disclosure relates to a compound of formula (I) or formula (II) or a pharmaceutically acceptable salt thereof, for use in the treatment of hypertrophic cardiomyopathy.
Nucleic acids encoding antibodies to matrix metalloproteinase 9
Granted: September 1, 2015
Patent Number:
9120863
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), wherein the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
Fused heterocyclic compounds as ion channel modulators
Granted: August 25, 2015
Patent Number:
9115096
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein Q, R1, X1, X2, Y and R2 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
Methods and intermediates for preparing pharmaceutical agents
Granted: August 25, 2015
Patent Number:
9115100
The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.
