Crystalline pyridazine compound
Granted: October 29, 2013
Patent Number:
8569488
A crystalline compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections Methods of making and formulating crystalline compound (1) are provided.
Pyridazine compound and use thereof
Granted: October 29, 2013
Patent Number:
8569487
A compound of formula (1) and its salts and solvates are provided for the treatment or prophylaxis of hepatitis C virus infections. Methods of making and formulating compound (1) are provided.
Inhibitors of flaviviridae viruses
Granted: October 29, 2013
Patent Number:
8569302
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Compounds for the treatment of addiction
Granted: October 15, 2013
Patent Number:
8558001
Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a…
Apoptosis signal-regulating kinase inhibitors
Granted: October 8, 2013
Patent Number:
8552196
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the…
2,4,6-trisubstituted pyrido(3,2-d)pyrimidines useful for treating viral infections
Granted: September 17, 2013
Patent Number:
8536187
Pyrido(3,2-d)pyrimidine derivatives represented by the structural formula (Ia): wherein, R1, R2 and R3 are defined herein, pharmaceutical acceptable addition salts, stereochemical isomeric forms, N-oxides, solvates and pro-drugs thereof, for use in the treatment of hepatitis C.
Methods of myocardial perfusion imaging
Granted: September 17, 2013
Patent Number:
8536150
The present invention provides a method of myocardial perfusion imaging using reduced doses of (1-{9-[(4S,2R,3R,5R)3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide.
Monohydrate of (1-{9-[4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide
Granted: September 3, 2013
Patent Number:
8524883
Disclosed is a synthesis suitable for large scale manufacture of an A2A-adenosine receptor agonist, namely, (1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2-yl}pyrazol-4-yl)-N-methylcarboxamide. Also, disclosed are polymorphs of this compound and methods for isolating a specific polymorph. Also, disclosed are pharmaceutical compositions and methods for preparing pharmaceutical compositions.
Inhibitors of viruses
Granted: September 3, 2013
Patent Number:
8524764
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Inhibitors of flaviviridae viruses
Granted: August 20, 2013
Patent Number:
8513298
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Method of treating atrial fibrillation
Granted: August 20, 2013
Patent Number:
8513254
The present invention relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a synergistically therapeutic amount of dronedarone or a pharmaceutically acceptable salt or salts thereof and a synergistically therapeutic amount of ranolazine or a pharmaceutically acceptable salt or salts thereof. Also provided are methods for modulating ventricular and atrial rhythm and rate. This invention also relates to…
Antiviral compounds
Granted: August 20, 2013
Patent Number:
8513186
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Macrocyclic inhibitors of flaviviridae viruses
Granted: August 20, 2013
Patent Number:
8513184
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Modulators of toll-like receptors
Granted: August 13, 2013
Patent Number:
8507507
The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
Inhibitors of viruses
Granted: August 6, 2013
Patent Number:
8501714
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of Flaviviridae virus infections, particularly hepatitis C infections.
Methods and intermediates for preparing pharmaceutical agents
Granted: July 30, 2013
Patent Number:
8497396
The invention provides methods and intermediates that are useful for preparing a compound of formula I: and salts thereof.
Pyrazolo[1,5-a]pyrimidines for antiviral treatment
Granted: July 16, 2013
Patent Number:
8486938
The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
Dihydropyrido[4,3-b]pyrazine-3-ones as modulators of toll-like receptors
Granted: July 2, 2013
Patent Number:
8476270
The present invention relates to novel dihydropyrido[4,3 -b]pyrazin-3(4H)-ones of the general formula: useful as modulators of toll-like receptors, and to pharmaceutical compositions containing them.
Antiviral compounds
Granted: July 2, 2013
Patent Number:
8476225
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
Myocardial perfusion imaging methods and compositions
Granted: June 25, 2013
Patent Number:
8470801
A myocardial imaging method that is accomplished by administering one or more adenosine A2A adenosine receptor agonist to a human undergoing myocardial imaging as well as pharmaceutical compositions comprising at least one A2a receptor agonist, at least one liquid carrier, and at least one co-solvent.
