Compounds for inhibition of ?4?7 integrin
Granted: November 23, 2021
Patent Number:
11179383
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
Imidazopyridine derivatives
Granted: November 16, 2021
Patent Number:
11174256
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
Antibodies that target HIV GP120 and methods of use
Granted: November 9, 2021
Patent Number:
11168130
Antibodies that bind to HIV gp120 and neutralize HIV are disclosed. Also disclosed are methods of using such antibodies alone or in combination with other therapeutic agents to treat or prevent HIV infection.
FLT3L-FC fusion proteins
Granted: September 21, 2021
Patent Number:
11124582
Provided are FLT3L-Fc fusion proteins, polynucleotides encoding such fusion proteins, expression cassettes, vectors, cells and kits comprising such fusion proteins, and methods of using.
Toll like receptor modulator compounds
Granted: September 21, 2021
Patent Number:
11124487
This application relates generally to toll like receptor modulator compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR8), and methods of making and using them.
Methods and intermediates for preparing therapeutic compounds
Granted: September 14, 2021
Patent Number:
11117886
The present disclosure relates to methods and intermediates useful for preparing a compound of formula I: or a co-crystal, solvate, salt or combination thereof.
Modulators of toll-like receptors for the treatment of HIV
Granted: September 14, 2021
Patent Number:
11116774
Provided are methods, uses, pharmaceutical regimens, pharmaceutical compositions, and kits comprising modulators of TLR7, including those of Formula II: and pharmaceutically acceptable salts thereof, useful in treating HIV infections.
Quinoline derivatives
Granted: September 14, 2021
Patent Number:
11116760
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), and therapeutic methods for treating inflammatory disease.
Modulators of toll-like receptors
Granted: September 7, 2021
Patent Number:
11110091
Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Apoptosis signal-regulating kinase inhibitors
Granted: August 31, 2021
Patent Number:
RE48711
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the…
Therapeutic heterocyclic compounds
Granted: August 24, 2021
Patent Number:
11098027
Compounds having the following Formula (I), or a pharmaceutically acceptable salt thereof, and methods of their use and preparation are disclosed:
Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
Granted: August 10, 2021
Patent Number:
11084832
Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
HIV inhibitor compounds
Granted: August 3, 2021
Patent Number:
11078208
The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.
Solid forms of a toll-like receptor modulator
Granted: July 27, 2021
Patent Number:
11072615
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropteridin-6(5H)-one, and methods of making.
Substituted 6-azabenzimidazole compounds
Granted: July 27, 2021
Patent Number:
11071730
The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
Cot modulators and methods of use thereof
Granted: July 20, 2021
Patent Number:
11066414
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
Pyrrolo[1,2-b]pyridazine derivatives
Granted: July 6, 2021
Patent Number:
11053250
A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
Anti-HIV compounds
Granted: July 6, 2021
Patent Number:
11052087
The invention provides compounds having Formula (I): or a pharmaceutically acceptable salt thereof, as well as pharmaceutical compositions comprising the same, processes for their preparation, and methods of treating and preventing HIV infection by their administration.
Thiadiazole IRAK4 compounds
Granted: June 29, 2021
Patent Number:
11046686
A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
Therapeutic heterocyclic compounds
Granted: June 22, 2021
Patent Number:
11040033
Compounds having the following Formula I and/or Formula II and methods of their use and preparation are disclosed:
