Quantum Patent Applications

ENRICHMENT OF NUCLEIC ACID TARGETS

Granted: August 15, 2019
Application Number: 20190249234
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.

PULSED LASER AND BIOANALYTIC SYSTEM

Granted: August 15, 2019
Application Number: 20190249240
Apparatus and methods for producing ultrashort optical pulses are described. A high-power, solid-state, passively mode-locked laser can be manufactured in a compact module that can be incorporated into a portable instrument for biological or chemical analyses. The pulsed laser may produce sub-100-ps optical pulses at a repetition rate commensurate with electronic data-acquisition rates. The optical pulses may excite samples in reaction chambers of the instrument, and be used to generate…

MACHINE LEARNING ENABLED PULSE AND BASE CALLING FOR SEQUENCING DEVICES

Granted: August 1, 2019
Application Number: 20190237160
A method includes obtaining, from one or more sequencing devices, raw data detected from luminescent labels associated with nucleotides during nucleotide incorporation events; and processing the raw data to perform a comparison of base calls produced by a learning enabled, automatic base calling module of the one or more sequencing devices with actual values associated with the raw data, wherein the base calls identify one or more individual nucleotides from the raw data. Based on the…

ENRICHMENT OF NUCLEIC ACID TARGETS

Granted: July 11, 2019
Application Number: 20190210641
Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.

SYSTEM AND METHODS FOR ELECTROKINETIC LOADING OF SUB-MICRON-SCALE REACTION CHAMBERS

Granted: July 11, 2019
Application Number: 20190211389
Apparatus and techniques for electrokinetic loading of samples of interest into sub-micron-scale reaction chambers are described. Embodiments include an integrated device and related apparatus for analyzing samples in parallel. The integrated device may include at least one reaction chamber formed through a surface of the integrated device and configured to receive a sample of interest, such as a molecule of nucleic acid. The integrated device may further include electrodes patterned…

INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES

Granted: July 11, 2019
Application Number: 20190212265
System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes at least one waveguide configured to propagate excitation energy to the sample wells from a region of the integrated device configured to couple with an excitation energy source. A pixel may also include at least one element for directing…

Device Providing Body Temperature Regulation and/or Therapeutic Light Directed to Vasculature

Granted: June 13, 2019
Application Number: 20190175935
One bracelet embodiment provides therapeutic blood irradiation at a first wrist region using a first module, and body temperature regulation/irradiation at a second wrist region using a second module. A connector couples one end of the modules together, while an attachment band releasably couples the second ends together, for attachment to the wrist. The first module includes first and second distributed pluralities of lights respectively emitting 850 and 660 nm wavelengths, and a third…

IMPROVED TARGET CELL CONCENTRATION USING DIELECTROPHORESIS (DEP)

Granted: June 13, 2019
Application Number: 20190176151
Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the…

RECOVERY OF A METAL FROM PRIMARY AND SECONDARY SULPHURATED MINERALS AND OXIDIZED MINERALS, AND OTHER COMPOSITIONS OF VALUABLE MINERALS

Granted: April 4, 2019
Application Number: 20190100846
A method to separate and recover at least one metal from a source of oxidized and/or primary and secondary sulfide ores by determining and modifying the values of the dielectric constant of the minerals source.

ACCURATE AND EFFICIENT RECORDING OF USER EXPERIENCE, GUI CHANGES AND USER INTERACTION EVENTS ON A REMOTE WEB DOCUMENT

Granted: March 28, 2019
Application Number: 20190095408
The present disclosure describes how to capture events (e.g., changes and user interactions) of a Web document and combine those changes with the original DOM displayed to accurately and efficiently enable a replay engine to redisplay the DOM, changes, and user interactions which occurred within a user's browser. The data collected from a client-side HTML DOM capture engine can be combined with a minimal amount of contextual information to a replay engine so as to accurately and…

HIGH ENERGY VISIBLE LIGHT ABSORBING MATERIAL FOR OPHTHALMIC SUBSTRATE AND APPLICATION METHOD

Granted: March 14, 2019
Application Number: 20190079318
A high energy visible (HEV) light absorbing material for an ophthalmic substrate and application through physical vapor deposition. The HEV light absorbing material is deposited onto the ophthalmic substrate, such as an optical lens. The HEV light absorbing material is applied through physical vapor deposition. The HEV light absorbing material is applied as a thin layer on ophthalmic substrates for flexibility and color adaptation. The HEV light absorbing material includes at least one…

Quantum NPS Photodetector

Granted: February 28, 2019
Application Number: 20190067500
This invention describes a Quantum NPS Photodetector (QNPSPD). A plurality of dispersed patterned Nanoporous Silicon island regions with sub 50 nm pore nc-pSi nanostructure are formed in a high resistivity Si substrate on the first side of a front illuminated QNPSPD device with each nc-pSi region surrounded along its perimeter by a contiguous interconnected p/n diode junction. The Quantum NPS Photodetector is characterized by enhanced responsivity in the spectral range of from about 0.2…

LITHIUM SELECTIVE PERMEABLE MEMBRANE, LITHIUM RECOVERY DEVICE, LITHIUM RECOVERY METHOD, AND HYDROGEN PRODUCTION METHOD

Granted: January 31, 2019
Application Number: 20190032230
The disclosure relates to recovering Li ions in a raw liquid into a recovery liquid at a high recovery speed. A lithium selective permeable membrane is constituted of a selective permeable membrane main body constituted of a lithium ion superconductor (ion conductor) having a particularly high ion conductivity and a Li adsorption layer formed as a thin layer on a raw liquid side (a first electrode) thereof. As a material constituting the selective permeable membrane main body,…

HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING

Granted: January 24, 2019
Application Number: 20190024168
Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.

HAND-HELD, MASSIVELY-PARALLEL, BIO-OPTOELECTRONIC INSTRUMENT

Granted: January 24, 2019
Application Number: 20190025214
A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering…

OPTICAL REJECTION PHOTONIC STRUCTURES

Granted: January 24, 2019
Application Number: 20190025511
An integrated device and related instruments and systems for analyzing samples in parallel are described. The integrated device may include sample wells arranged on a surface of where individual sample wells are configured to receive a sample labeled with at least one fluorescent marker configured to emit emission light in response to excitation light. The integrated device may further include photodetectors positioned in a layer of the integrated device, where one or more photodetectors…

Quantum Mechanical/X-Ray Crystallography Diagnostic for Proteins

Granted: January 24, 2019
Application Number: 20190026421
The invention is a diagnostic which overlays quantum mechanical analysis to x-ray crystallography data from one or more proteins to assess and identify the real world conformation, protonation and solvent effects of one or more moieties in said protein. This “overlay” occurs by scoring and identifying the protomer/tautomer states of the moieties using quantum mechanical analysis. The diagnostic results of the present invention accurately identify protein-ligand binding, rendered as…

METHOD FOR GENERATING RANDOM NUMBERS AND ASSOCIATED RANDOM NUMBER GENERATOR

Granted: January 10, 2019
Application Number: 20190012145
A random signal can be obtained from a random tunneling of charges from one conductor to another conductor across a quantum tunneling barrier. The random signal can be amplified and associated to a random number. The association can be performed repetitively to generate a sequence of random numbers.

COMPOSITE PRESSURE VESSEL HAVING INTERNAL LOAD SUPPORT

Granted: December 27, 2018
Application Number: 20180372272
A device, system and method to support the ends of composite pressurized storage vessel, including supporting two ends of a cylindrical composite pressurized storage vessel with an axial rod/tube fixed axially inside the storage vessel fixed at each end; and providing a fluid pathway into the vessel from at least one of the two ends which is not obstructed by the axial rod/tubing.

POLYMERIZING ENZYMES FOR SEQUENCING REACTIONS

Granted: December 20, 2018
Application Number: 20180362941
Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.