Quantum Patent Applications

LITHIUM SELECTIVE PERMEABLE MEMBRANE, LITHIUM RECOVERY DEVICE, LITHIUM RECOVERY METHOD, AND HYDROGEN PRODUCTION METHOD

Granted: January 31, 2019
Application Number: 20190032230
The disclosure relates to recovering Li ions in a raw liquid into a recovery liquid at a high recovery speed. A lithium selective permeable membrane is constituted of a selective permeable membrane main body constituted of a lithium ion superconductor (ion conductor) having a particularly high ion conductivity and a Li adsorption layer formed as a thin layer on a raw liquid side (a first electrode) thereof. As a material constituting the selective permeable membrane main body,…

HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING

Granted: January 24, 2019
Application Number: 20190024168
Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleic acid connected to a nucleotide and two or more luminescent labels. In some embodiments, the nucleic acids described herein comprise one or more structural features that provide enhanced fluorescence intensity. In some aspects, methods of sequencing using the labeled nucleotides of the disclosure are provided.

HAND-HELD, MASSIVELY-PARALLEL, BIO-OPTOELECTRONIC INSTRUMENT

Granted: January 24, 2019
Application Number: 20190025214
A hand-held bioanalytic instrument is described that can perform massively parallel sample analysis including single-molecule gene sequencing. The instrument includes a pulsed optical source that produces ultrashort excitation pulses and a compact beam-steering assembly. The beam-steering assembly provides automated alignment of excitation pulses to an interchangeable bio-optoelectronic chip that contains tens of thousands of reaction chambers or more. The optical source, beam-steering…

OPTICAL REJECTION PHOTONIC STRUCTURES

Granted: January 24, 2019
Application Number: 20190025511
An integrated device and related instruments and systems for analyzing samples in parallel are described. The integrated device may include sample wells arranged on a surface of where individual sample wells are configured to receive a sample labeled with at least one fluorescent marker configured to emit emission light in response to excitation light. The integrated device may further include photodetectors positioned in a layer of the integrated device, where one or more photodetectors…

Quantum Mechanical/X-Ray Crystallography Diagnostic for Proteins

Granted: January 24, 2019
Application Number: 20190026421
The invention is a diagnostic which overlays quantum mechanical analysis to x-ray crystallography data from one or more proteins to assess and identify the real world conformation, protonation and solvent effects of one or more moieties in said protein. This “overlay” occurs by scoring and identifying the protomer/tautomer states of the moieties using quantum mechanical analysis. The diagnostic results of the present invention accurately identify protein-ligand binding, rendered as…

METHOD FOR GENERATING RANDOM NUMBERS AND ASSOCIATED RANDOM NUMBER GENERATOR

Granted: January 10, 2019
Application Number: 20190012145
A random signal can be obtained from a random tunneling of charges from one conductor to another conductor across a quantum tunneling barrier. The random signal can be amplified and associated to a random number. The association can be performed repetitively to generate a sequence of random numbers.

COMPOSITE PRESSURE VESSEL HAVING INTERNAL LOAD SUPPORT

Granted: December 27, 2018
Application Number: 20180372272
A device, system and method to support the ends of composite pressurized storage vessel, including supporting two ends of a cylindrical composite pressurized storage vessel with an axial rod/tube fixed axially inside the storage vessel fixed at each end; and providing a fluid pathway into the vessel from at least one of the two ends which is not obstructed by the axial rod/tubing.

POLYMERIZING ENZYMES FOR SEQUENCING REACTIONS

Granted: December 20, 2018
Application Number: 20180362941
Compositions comprising modified recombinant polymerizing enzymes are provided, along with nucleic acid molecules encoding the modified polymerizing enzymes. In some aspects, methods of using such polymerizing enzymes to synthesize a nucleic acid molecule or to sequence a nucleic acid template are provided.

STAIR TRAVERSING DEVICE

Granted: December 6, 2018
Application Number: 20180344547
A stair traversing device comprising a payload body for transporting a payload, a step frame, and a mechanism between the step frame and the payload body to move the step frame relative to the payload body along a cyclical path. The mechanism drives a movement of one of the payload body and the step frame along a first segment of the cyclical path from a retracted configuration to an extended configuration, and drives a movement of the other one of the payload body and the step frame…

ACTIVE-SOURCE-PIXEL, INTEGRATED DEVICE FOR RAPID ANALYSIS OF BIOLOGICAL AND CHEMICAL SPECIMENS

Granted: December 6, 2018
Application Number: 20180348132
An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that…

ACTIVE-SOURCE-PIXEL, INTEGRATED DEVICE FOR RAPID ANALYSIS OF BIOLOGICAL AND CHEMICAL SPECIMENS

Granted: December 6, 2018
Application Number: 20180348133
An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample. The sensor may comprise two or more segments that produce a set of signals that…

OPTICAL DUAL-COMB SOURCE APPARATUSES INCLUDING OPTICAL MICRORESONATOR

Granted: December 6, 2018
Application Number: 20180351319
Provided is an optical source apparatus that may generate two different optical frequency combs. The optical source apparatus includes an optical resonator and a continuous wave laser emitting laser light having a spectrum component corresponding to a resonance frequency of the optical resonator, and the optical resonator is configured to generate a first frequency comb and a second frequency comb having different modes by interacting with the laser light emitted by the continuous wave…

SUBSTRATES HAVING MODIFIED SURFACE REACTIVITY AND ANTIFOULING PROPERTIES IN BIOLOGICAL REACTIONS

Granted: November 15, 2018
Application Number: 20180326412
Methods of preparing surfaces of sample wells are provided. In some aspects, methods of preparing a sample well surface involve contacting the sample well with a block copolymer to form an antifouling overlay over a metal oxide surface of the sample well. In some aspects, methods of passivating and/or selectively functionalizing a sample well surface are provided.

INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES

Granted: November 15, 2018
Application Number: 20180328850
Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated…

WAVEGUIDE CONNECTOR COUPLERS AND ADAPTERS

Granted: November 8, 2018
Application Number: 20180323487
A waveguide connector assembly for coupling a waveguide to a microwave device includes a male part and a female part. The male part includes a threaded external cylindrical surface defining a male center axis, a first end surface, and a second end surface opposed to the first end surface. The female part includes a first annular end surface, a second annular end surface opposed to the first annular surface, a threaded internal cylindrical surface configured to engage with the threaded…

ACCELERATOR CONTROL DEVICE, ACCELERATOR CONTROL METHOD, AND PARTICLE BEAM THERAPY DEVICE

Granted: November 1, 2018
Application Number: 20180317311
According to some embodiments, an accelerator control device has a high-frequency power controller and a timing controller. The high-frequency power controller supplies high frequency power for accelerating a charged particle beam to an accelerator. The tinting controller controls an operation timing of a blocker that blocks the charged particle beam emitted from the accelerator based on a current value of the charged particle beam circulating in the accelerator.

Composite Vessel Fire Protection System

Granted: September 20, 2018
Application Number: 20180266577
A localized fire protection system for composite overwrapped pressure vessels which uses net or mesh which stretches in at least one direction. They can be elastomeric or polymeric or any material and/or weave that provides said function. Wrapping sections held together via a flammable fuse connected to a relief valve under pressure from the net wrappings to block a relief valve pathway to replace stored gas in case of a localized fire.

INTEGRATED DEVICE FOR TEMPORAL BINNING OF RECEIVED PHOTONS

Granted: September 13, 2018
Application Number: 20180259456
An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier…

PARTIAL-RING PET DEVICE AND PET DEVICE

Granted: August 23, 2018
Application Number: 20180239037
A partial-ring PET device, in which some of coincidence radiation detectors to be arranged in a ring shape around a field of view for detecting lines of response of annihilation radiations are missing, is compensated for a drop in image quality due to the missing of the coincidence radiation detectors by including single gamma-ray radiation detectors for detecting at least either one of the annihilation radiations as a single gamma-ray. This can reduce missing of projection angles and…

OPTICAL SYSTEM AND ASSAY CHIP FOR PROBING, DETECTING AND ANALYZING MOLECULE

Granted: August 16, 2018
Application Number: 20180231465
Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces…