Analogs of thymosin &agr;1
Granted: July 17, 2001
Patent Number:
6262230
Compounds of the formula:
X-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser- (I)
Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Z
wherein X is an acetyl or pyroglutamyl group and Z is —NH2, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Pro-NH2, -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Gly-NH2, or -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn with the proviso that when X is a pyroglutamyl group, Z is -Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn, and when X is an acetyl group, Z…
Combination therapy method for treating chronic hepatitis B
Granted: March 13, 2001
Patent Number:
6200952
The present invention is aimed at augmenting the success rate of using thymosin in treatment of chronic hepatitis B, by employing a combination therapy using thymosin with antiviral agents which are effective in inhibiting DNA synthesis or DNA polymerase during replication of the hepatitis B virus.
Method of treating hepatitis C in non-responders to interferon treatment
Granted: December 14, 1999
Patent Number:
6001799
A method of treating Hepatitis C by administering an immune system-potentiating dose of at least one Thymosin or system-potentiating Thymosin fragment to a mammal infected with Hepatitis C virus, which Hepatitis C infection in the mammal is non-responsive to treatment with interferon alone.
Treatment of hepatitis B infection with thymosin alpha 1 and famciclovir
Granted: August 17, 1999
Patent Number:
5939423
Treatment of hepatitis B virus (HBV) infection in a patient by administering to the patient a drug regimen including an antiviral-effective amount of thymosin alpha 1 (T.alpha.1) and an antiviral-effective amount of famciclovir.
Composition and method of treating hepatitis C
Granted: December 15, 1998
Patent Number:
5849696
Compositions and methods of use for treating hepatitis C virus-infected mammals are disclosed. The compositions include one or more thymosins alone or in combination with one or more interferons. Methods of treatment include use of thymosins alone, or together, or sequentially with interferon.
Method for treating hepatitis B carriers with minimal disease
Granted: May 3, 1994
Patent Number:
5308833
Methods for treating minimal disease hepatitis B infection are disclosed. Minimal disease carriers are given thymosin .alpha.-1, or biologically active fragments or analogs thereof In this way, the indications of hepatitis B can be reduced or eliminated.
