Systems, methods, and devices for high-energy irradiation
Granted: February 9, 2021
Patent Number:
10912952
A high-energy radiation treatment system can comprise a laser-driven accelerator system, a patient monitoring system, and a control system. The laser-driven accelerator system, such as a laser-driven plasma accelerator or a laser-driven dielectric microstructure accelerator, can be constructed to irradiate a patient disposed on a patient support. The patient monitoring system can be configured to detect and track a location or movement of a treatment volume within the patient. The…
Method and apparatus pertaining to radiation-treatment plan optimization
Granted: February 9, 2021
Patent Number:
10912951
A radiation-treatment plan that comprises a plurality of dose-delivery fractions can be optimized by using fraction dose objectives and at least one other, different dose objective. This use of fraction dose objectives can comprise accumulating doses delivered in previous dose-delivery fractions. The other, different dose objective can comprise a remaining total dose objective, a predictive dose objective, or some other dose objective of choice. An existing radiation-treatment plan…
Multi-criteria optimization tools including time-based criteria for radiation therapy
Granted: February 9, 2021
Patent Number:
10912949
Multi-criteria optimization of radiation therapy tools for receiving a plurality of criteria including one or more sets of competing objectives. The competing objective can include delivery time criteria, fractionation criteria or similar time-based criteria. One or more radiation therapy plans can be determined based on a multi-criteria optimization of the plurality of criteria for the radiation therapy treatment. The one or more optimized radiation therapy plans can be output for…
Radiation anode target systems and methods
Granted: February 2, 2021
Patent Number:
10910188
Presented systems and methods facilitate efficient and effective generation and delivery of radiation. A radiation generation system can comprise: a particle beam gun, a high energy dissipation anode target (HEDAT); and a liquid anode control component. In some embodiments, the particle beam gun generates an electron beam. The HEDAT includes a solid anode portion (HEDAT-SAP) and a liquid anode portion (HEDAT-LAP) that are configured to receive the electron beam, absorb energy from the…
Triggered treatment systems and methods
Granted: January 26, 2021
Patent Number:
10898730
In various embodiments, a radiation therapy method can include loading a planning image of a target in a human. In addition, the position of the target can be monitored. A computation can be made of an occurrence of substantial alignment between the position of the target and the target of the planning image. Furthermore, after the computing, a beam of radiation is triggered to deliver a dosage to the target in a short period of time (e.g., less than a second).
Phantom setup and source-to-surface distance verification using radiation imaging
Granted: January 26, 2021
Patent Number:
10898158
A phantom setup and source-to-surface distance (SSD) verification method uses radiation images. In an exemplary method, a phantom is positioned on a support relative to a radiation source such that a surface of the phantom is horizontally leveled at or approximate to a desired value of SSD. The radiation source is then positioned at a gantry angle predetermined at least based on the desired value of SSD such that a ray of radiation from the radiation source aligns with a horizontal…
Multileaf collimator with alternating trapezoidal leaf geometry design
Granted: January 12, 2021
Patent Number:
10888713
A multileaf collimator includes a plurality of beam-blocking leaves of a first type and a plurality of beam-blocking leaves of a second type. The beam-blocking leaves of the first type are alternatingly arranged with the beam-blocking leaves of the second type side by side. Each of the beam-blocking leaves of the first type has a trapezoidal geometry viewed in the leaf longitudinal moving direction comprising a wider end and a narrower end with the wider end being proximal to a source.…
Dynamic patient positioning system
Granted: January 5, 2021
Patent Number:
10881878
A system includes a first radiation source configured to provide therapeutic radiation in a treatment area and an automated patient transport configured to transport a patient from a preparation area to the treatment area, to position a treatment volume in the patient relative to the therapeutic radiation from the first radiation source, and to support the patient in receiving the therapeutic radiation. The automated patient transport comprises a first detector configured to detect a…
Beam position monitors for medical radiation machines
Granted: December 29, 2020
Patent Number:
10879028
An apparatus includes: a structure having a lumen for accommodating a beam (e.g., electron beam, proton beam, or a charged particle beam), wherein the structure is a component of a medical radiation machine having a target for interaction with the beam to generate radiation; and a first beam position monitor comprising a first electrode and a second electrode, the first electrode being mounted to a first side of the structure, the second electrode being mounted to a second side of the…
Non-achromatic compact gantry
Granted: December 15, 2020
Patent Number:
10864384
Embodiments of the present invention provide a compact gantry designed to provide particle therapy using a particle beam. A gantry for providing the particle therapy comprises a first dipole magnet operable to bend a particle beam received from a cyclotron by a first degree amount. The gantry further comprises a plurality of quadrupole magnets configured to condition the beam asymmetrically to produce an asymmetric beam, wherein a configuration of the quadrupole magnets is determined…
System and method for in-layer synchronization for fast spot rescanning
Granted: December 8, 2020
Patent Number:
10857392
To overcome the difficulties inherent in conventional proton therapy systems, new techniques are described herein for synchronizing the application of proton radiation with the periodic movement of a target area. In an embodiment, a method is provided that combines multiple rescans of a spot scanning proton beam while monitoring the periodic motion of the target area, and aligning the applications of the proton beam with parameters of the periodic motion. For example, the direction(s)…
Controlling and shaping the dose distribution outside treatment targets in external-beam radiation treatments
Granted: December 8, 2020
Patent Number:
10857384
Streamlined and partially automated methods of setting normal tissue objectives in radiation treatment planning are provided. These methods may be applied to multiple-target cases as well as single-target cases. The methods can impose one or more target-specific dose falloff constraints around each target, taking into account geometric characteristics of each target such as target volume and shape. In some embodiments, methods can also take into account a planner's preferences for target…
Systems and methods for interactive control of window/level parameters of multi-image displays
Granted: December 1, 2020
Patent Number:
10854173
A technology enables interactive control of simultaneously displayed multiple images with high dynamic ranges, which software automation processes are programmed to reduce the complexity in managing and viewing the post window/level adjustment of the multiple images. An image control engine provides several synchronous functional capabilities, which comprises an input module, a blending factor synchronization module, a window/level synchronization module, a display module, and an image…
Dose-distribution estimation in proton therapy
Granted: December 1, 2020
Patent Number:
10850129
A system for estimating a dose from a proton therapy plan includes a memory that stores machine instructions and a processor coupled to the memory that executes the machine instructions to subdivide a representation of a volume of interest in a patient anatomy traversed by a planned proton field into a plurality of voxels. The processor further executes the machine instructions to determine the distance from the source of the planned proton beam to one of the voxels. The processor also…
Dose aspects of radiation therapy planning and treatment
Granted: December 1, 2020
Patent Number:
10850124
Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and…
Selecting a dose prediction model based on clinical goals
Granted: December 1, 2020
Patent Number:
10850120
A clinical goal for radiation treatment of a patient is set. A dose prediction model is selected from a number of dose prediction models based on the clinical goal. A radiation treatment plan is then generated for the patient using the dose prediction model that was selected based on the clinical goal.
Biomarkers for radiation treatment
Granted: November 24, 2020
Patent Number:
10844437
The methods described herein allow for the classification of patients into groups for receiving optimized radiation treatment based on patient specific biomarker signature. The biomarker signature includes markers that have been shown to correlate with TGF-B expression and to be associated with tumor aggressiveness, radioresistance and poor prognosis. The markers play a key role in the epithelial-mesenchymal transition. The methods described herein provide the dual benefits of anti-tumor…
Particle beam gun control systems and methods
Granted: November 24, 2020
Patent Number:
10843011
Presented systems and methods facilitate efficient and effective monitoring of particle beams. In some embodiments, a radiation gun system comprises: a particle beam gun that generates a particle beam, and a gun control component that controls the gun particle beam generation characteristics, including particle beam fidelity characteristics. The particle beam characteristics can be compatible with FLASH radiation therapy. Resolution control of the particle beam generation can enable dose…
Projection mapping of radiation suites
Granted: November 24, 2020
Patent Number:
10842454
A radiation suite includes a room having a floor, a ceiling, and one or more walls, a radiation system including a gantry enclosing a radiation source and a couch, and an image projection system operable to project an image on a projection surface on at least a portion of the gantry and/or the couch, providing a calming environment for a patient to relax. The image projection system comprises a computer and one or more projectors operably controlled by the computer. The computer…
Methods to optimize coverage for multiple targets simultaneously for radiation treatments
Granted: November 17, 2020
Patent Number:
10835760
A cost function is constructed so as to guide an optimization process to achieve similar coverage for all targets simultaneously in a concurrent radiation treatment of multiple targets, so that a single scaling factor may be used in a plan normalization to achieve the desired coverage for all the targets. The cost function includes a component that favors a solution that attains similar target coverages for all targets, as well as a component that favors a solution that approaches the…
