APPARATUS AND METHODS FOR PIPETTING WITH INTERCHANGEABILITY AMONG DIFFERENT PIPETTE TIPS
Granted: August 7, 2014
Application Number:
20140219887
Pipette tips of different sizes may be coupled to a pipettor without needing to modify the pipettor. The same pipettor may thus be utilized to exchange different pipette tips, which may be done in an automated manner. Pipette tips may be coupled to adaptors that include proximal ends for interfacing with the pipettor and distal ends for interfacing with pipette tips. The proximal ends may all have the same geometry, matched with the same pipettor. The distal ends may have different…
TRANSVERSE VOLUME COILS AND RELATED MAGNETIC RESONANCE SYSTEMS AND METHODS
Granted: August 7, 2014
Application Number:
20140218025
A transverse volume magnetic resonance (MR) coil includes a cylindrical geometry of electrical conductors configured for generating a B1 field comprising nth mode spatial harmonics along a first transverse axis in a transverse plane orthogonal to a central axis of the coil, while being uniform along a second transverse axis orthogonal to the first transverse axis in the transverse plane, where n is an integer ranging from 1 or greater. The coil may be included with other coils in an…
Sequential Low/High-Resolution Library Search
Granted: August 7, 2014
Application Number:
20140217276
Provided herein are systems and method for using unit mass library searches for sample identification in accurate mass spectrometry. In general, the systems and methods described herein: (a) obtain an accurate mass spectrum of a sample; (b) calculate a unit mass spectrum based on the accurate mass spectrum; and (c) conduct a unit mass library search, based on the calculated unit masses, to obtain at least one candidate species to thereby identify the sample. The systems and methods may…
Method for Utilizing Projected Gesture Completion to Improve Instrument Performance
Granted: July 31, 2014
Application Number:
20140215382
A method of operating a first data processing system having a screen for responding to a vector gesture performed on that screen is disclosed. The method includes estimating a direction and assuming an identity for the vector gesture prior to the vector gesture being completed. A command that depends on the estimated direction and assumed identity is executed, the command being a command that would be required to update a current state of the first data processing system if the assumed…
Method for Automatically Adjusting the Magnification and Offset of a Display to View a Selected Feature
Granted: July 31, 2014
Application Number:
20140215379
A method for operating a display in a data processing system to provide a view of a portion of a data array on a display screen is disclosed. The method includes providing a first display window characterized by a first offset, a first horizontal gain, and a first vertical gain and receiving a feature input from a user indicating a selected feature in the first display window. The data processing system automatically provides a second display window characterized by a second offset and a…
Nucleic Acid Proximity Assay Involving the Formation of a Three-way junction
Granted: July 31, 2014
Application Number:
20140212869
Provided herein is a proximity assay that, in certain embodiments, involves: (a) hybridizing a first oligonucleotide and a second oligonucleotide with a target nucleic acid, wherein the first oligonucleotide comprises: i. a region that is complementary to a first sequence in the target nucleic acid and ii. a barcode sequence; and the second oligonucleotide comprises i. a region that is complementary to a second region in the target and ii. the complement of the barcode sequence; and (b)…
REAL-TIME SPECTRUM ANALYZER INCLUDING FREQUENCY MASK GATE AND METHOD OF OPERATING THE SAME
Granted: July 24, 2014
Application Number:
20140207414
A real-time spectrum analyzer for measuring time domain data sampled from an input signal includes a processing unit and a density histogram memory unit. The processing unit includes an FFT engine, a frequency mask detector and a frequency mask gate. The FFT engine performs FFTs on the sampled time domain data to provide FFT spectra, each FFT spectrum including multiple FFT points. The frequency mask detector determines whether each FFT point in each spectrum meets a trigger condition,…
ENERGY DISSIPATING DEVICE FOR DC POWER SUPPLIES
Granted: July 17, 2014
Application Number:
20140198549
An energy dissipating device configured to connect to a power supply and to dissipate excess energy from a direct current (DC) rail in response to a change in power supply settings or operating characteristics. The energy dissipating device is connected to the DC rail, which conducts current generated by an AC/DC converter to at least one DC/DC converter. When power demand to the DC/DC converter is reduced, the DC/DC converter generates a supplemental current surge on the DC rail. A rail…
EFFICIENT CHILLER FOR A SUPERCRITICAL FLUID CHROMATOGRAPHY PUMP
Granted: July 10, 2014
Application Number:
20140190183
Methods and systems for pumping compressible fluids in high pressure applications such as high-pressure liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) applications are disclosed. An improved cooling device for a pump head for use in a supercritical fluid chromatography (SFC) system is described. A system for chilling a pumping system, includes a Peltier cooling element in thermal contact with a pump head, wherein the cooling element chills the pump head and a…
ELECTRONIC SYSTEM SUBJECT TO MEMORY OVERFLOW CONDITION
Granted: July 10, 2014
Application Number:
20140195703
A method of operating an electronic system comprises storing information corresponding to an input data stream in a first memory having a first operating rate, detecting an overflow condition of the first memory, generating overflow information in response to the detection of the overflow condition, storing the overflow information in a second memory having a second operating rate slower than the first operating rate, transferring the overflow information from the detector to a third…
DRIFTING TWO-DIMENSIONAL SEPARATION WITH ADAPTION OF SECOND DIMENSION GRADIENT TO ACTUAL FIRST DIMENSION CONDITION
Granted: July 3, 2014
Application Number:
20140183137
A control device for a sample separation apparatus, the sample separation apparatus including a first separation unit and a second separation unit downstream of the first separation unit and supplied with the fluidic sample after treatment by the first separation unit. A control device is configured for controlling the first separation unit to execute a primary separation sequence within a time interval for separating the fluidic sample into fractions, and for controlling the second…
INTERFEROMETER HAVING MULTIPLE SCAN CARRIAGES
Granted: June 26, 2014
Application Number:
20140175288
An interferometer includes a fixed assembly including a base, a beam splitter assembly and a fixed mirror, and a movable assembly including an upper scan carriage, a lower scan carriage and a movable mirror connected to the lower scan carriage. The pair of inner bearing flexures is connected to the base and the upper scan carriage, enabling movement of the upper scan carriage relative to the base, and the pair of outer bearing flexures is connected to the upper and lower scan carriages,…
Vacuum Ultraviolet Photon Source, Ionization Apparatus, and Related Methods
Granted: June 19, 2014
Application Number:
20140167612
A vacuum ultraviolet (VUV) photon source includes a body, a VUV window, electrodes disposed on the body outside an interior thereof, and a dielectric barrier between the electrodes. A method for generating VUV photons includes generating a dielectric barrier discharge (DBD) in an interior of a photon source by applying a periodic voltage between a first electrode and a second electrode separated by a dielectric barrier, wherein the DBD produces excimers from a gas in a gap between the…
CONTINUOUS BROKEN SENSE LEAD DETECTION SYSTEM
Granted: June 5, 2014
Application Number:
20140152335
Disclosed is a continuous broken sense lead detection system (“CBSLDS”) for use with a Kelvin-connected device under test (“DUT”), a power source, and detection system stimulus configured to provide a periodic stimulus voltage. The CBSLDS is configured to detect a discontinuity in a first sense lead, second sense lead, or both, that are in signal communication with the DUT. The CBSLDS includes a first transformer, second transformer, first DC-blocker, second DC-blocker, first…
MULTI-CAPILLARY COLUMN AND HIGH-CAPACITY IONIZATION INTERFACE FOR GC-MS
Granted: June 5, 2014
Application Number:
20140151546
A gas chromatograph-mass spectrometer (GC-MS) system includes a multi-capillary GC column coupled to a mass analyzer through an ionization interface. The ionization interface includes an ionization device and an ion guide configured for receiving a high-capacity gas-sample flow from the GC column and transmitting a compressed ion beam to the mass analyzer. The ion beam may be converging.
METHOD OF CONTROLLING FREQUENCY MODULATED-ATOMIC FORCE MICROSCOPE
Granted: May 29, 2014
Application Number:
20140150139
A method is provided for controlling an FM-AFM including a cantilever having a resonant frequency and an excitation system configured to oscillate the cantilever in response to a drive signal. The method includes determining latency of the excitation system; receiving a deflection signal indicating a deflection of a cantilever tip; mixing the deflection signal with a first sine signal output by a PLL indicating a frequency shift of a frequency response of the cantilever; measuring the…
TIME OF FLIGHT MASS SPECTROMETER
Granted: May 22, 2014
Application Number:
20140138526
A method of determining the mass-to-charge ratios of ions in a sample is disclosed. The method includes determining a data acquisition time, where the data acquisition time is a predetermined fraction of the greatest time of flight. The method also includes providing ions from a continuous beam of a sample to a time-of-flight mass analyzer at pulse intervals having a duration equal to the predetermined fraction of the greatest flight time. The method also includes measuring a peak width…
ATOMIC FORCE MICROSCOPE SYSTEM USING SELECTIVE ACTIVE DAMPING
Granted: May 15, 2014
Application Number:
20140137300
An atomic force microscope (AFM) system comprises a cantilever arm attached to a probe tip. The system controls a height of the cantilever arm to press the probe tip against a sample and then separate the probe tip from the sample, to detect a disturbance of the cantilever arm after the separation of the probe tip from the surface, and to engage active damping of the cantilever arm to suppress the disturbance.
Method for Enforcing Language Subsets
Granted: May 15, 2014
Application Number:
20140137088
A method of operating a data processing system to examine a compiled program for violations of a set of rules that do not constitute violations detected by the compiler that generated the program. The method includes obtaining a restricted rule set defined in terms of rules in a decompiled representation of the program. The method also includes decompiling the compiled program to the decompiled representation of the compiled program in which the restricted rule set is defined, examining…
FORWARD COUPLED DIRECTIONAL COUPLER
Granted: May 1, 2014
Application Number:
20140118082
Described is a directional coupler for forward coupling energy from an input port to a coupling port. The directional coupler has a coupling factor and an operating frequency and an operating wavelength corresponding to the operating frequency.
