Voltage-Current Characteristic Generator
Granted: May 1, 2014
Application Number:
20140117970
Disclosed is a voltage-current characteristic generator that includes: a voltage source; a current source; a selector for selecting and outputting the output of either the voltage source or the current source; a sensing portion, connected to an output of the selector, for outputting the output of the selector and for sensing, and feeding back, the voltage and current of the output; and a controller for receiving the voltage and current detected by the sensing portion and for setting the…
SAMPLE INJECTOR WITH DISCONNECTABLE INJECTION NEEDLE
Granted: May 1, 2014
Application Number:
20140116159
A sample injector (500) for injecting a fluid into a fluidic path, wherein the sample injector (500) comprises a robot arm (502) configured for moving an injection needle (506), when being connected to the robot arm (502), between a fluid container (510) containing the fluid and a seat (508) in fluid communication with the fluidic path, the injection needle (506) configured for aspirating the fluid from the fluid container (510), when the injection needle (506) has been moved to the…
Heterodyne Optical Spectrum Analyzer
Granted: April 24, 2014
Application Number:
20140111804
A heterodyne optical spectrum analyzer (10) is configured for analyzing spectral information of an optical input signal (15). The analyzer (10) comprises a local oscillator source (20) configured for generating an optical local oscillator signal (38). An optical mixer (25) is configured for receiving the input signal (15) and the local oscillator signal (38), and for outputting a plurality of different combined optical signals (50), each combined optical signal (50) being derived from…
TRANSIENT LEVEL DATA ACQUISITION AND PEAK CORRECTION FOR TIME-OF-FLIGHT MASS SPECTROMETRY
Granted: April 24, 2014
Application Number:
20140110574
Methods, apparatus and systems for acquiring spectrometric data from analyte ions implement transient-level data acquisition and peak correction in a time-of-flight mass spectrometer. Transient spectra including analyte peaks and reference mass peaks are recorded, from which a set of averaged peak centroids of the reference masses is generated. The peaks of reference masses in each transient spectrum are compared to the averaged peak centroids. From this comparison, an appropriate…
EXPANDED LINEAR RANGE BY USE OF TWO FLOW CELL DETECTORS WITH LONG AND SHORT PATH
Granted: April 3, 2014
Application Number:
20140095082
A sample detection apparatus (200) for detecting a fluidic sample flowing through a first flow cell (202) and flowing through a second flow cell (204) of a sample separation system (10), wherein the first flow cell (202) has a first path length (D) and the second flow cell (204) has a second path length (d) being smaller than the first path length (D), wherein the sample detection apparatus (200) comprises a data determining unit (206) configured for determining first data indicative of…
IMMOBILIZED TRANSPOSASE COMPLEXES FOR DNA FRAGMENTATION AND TAGGING
Granted: April 3, 2014
Application Number:
20140093916
The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting DNA. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. Purification is accomplished using a specific binding pair, in which one member of the pair is bound to an oligonucleotide adapter of the complex and the other member of the…
Thin Film with Improved Temperature Range
Granted: April 3, 2014
Application Number:
20140091422
A device and a method of forming the same are disclosed. The device comprises a substrate and a thin film. The substrate is characterized by a first coefficient of thermal expansion. The thin film is attached to a surface of the substrate, and is characterized by a second coefficient of thermal expansion. The thin film includes first and second layers in states of compression, and a third layer in a state of tension, the third layer being positioned between the first and second layers.…
RADIO FREQUENCY (RF) ION GUIDE FOR IMPROVED PERFORMANCE IN MASS SPECTROMETERS AT HIGH PRESSURE
Granted: March 27, 2014
Application Number:
20140084156
Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range. Some ion guides are provided between the ion source and the first stage vacuum chamber of the MS system.
DYNAMIC CREATION OF TREND GRAPH
Granted: March 27, 2014
Application Number:
20140086499
A method of generating a trend graph comprises storing a stream of data elements in a buffer having a storage capacity corresponding to a first number of data elements, compressing the stored data elements to fit within a display having a size corresponding to a second number of data elements smaller than the first number of data elements, detecting an event, and as a consequence detecting the event, compressing the stored data elements to occupy a reduced portion of the buffer.
THREE-FREQUENCY PHASE DIGITIZING SYSTEM AND METHOD OF THREE-PHASE DIGITIZING AN INTERFEROMETER SIGNAL USING THE SAME
Granted: March 27, 2014
Application Number:
20140085116
A phase digitizing system includes an analog-to-digital converter (ADC), multiple phase accumulators and a processing device. The ADC generates sample segments of digital signal waveform samples based on an analog composite input signal received in a measurement channel, the composite input signal includes a first signal having a first frequency F1 and a second signal imported from a reference channel having a second frequency F2. The processing device is coupled to the phase…
HYDROLYTICALLY STABLE ION-EXCHANGE STATIONARY PHASES AND USES THEREOF
Granted: March 27, 2014
Application Number:
20140083946
The invention provides novel ion-exchange media and related methods for their preparation and use. Ion-exchange stationary phases according to the invention are suitable for chromatographic separation of a variety of biomolecules. Distinguishing characteristics of ion-exchange media according to this invention includes, for example, their ability to separate variants of monoclonal antibodies via cation-exchange liquid chromatography using porous substrates with particle sizes <5 ?m.…
INTEGRATED PARTICLE TRAP FOR CAPILLARY PLOT COLUMNS
Granted: March 6, 2014
Application Number:
20140060331
A porous layer open tubular (PLOT) column includes capillary tubing; one or two particle traps disposed inside one or two end sections of the capillary tubing; and a stationary phase comprising a porous or non-porous material coated inside a main section of the capillary tubing. A method for preparing a porous layer open tubular (PLOT) column includes preparing one or two particle traps inside one or two end sections of a capillary tubing; and preparing a stationary phase comprising a…
SYSTEMS AND METHODS FOR MS-MS-ANALYSIS
Granted: February 6, 2014
Application Number:
20140034827
A mass spectrum is acquired by accumulating parent ions in an ion trap, ejecting parent ions of a selected m/z ratio into a collision cell, producing fragment ions from the parent ions, and analyzing the fragment ions in a mass analyzer. The other parent ions remain stored in the ion trap, and thus the process may be repeated by mass-selectively scanning parent ions from the ion trap. In this manner, the full mass range of parent ions or any desired subset of the full mass range may be…
ADJUSTING ENERGY OF IONS EJECTED FROM ION TRAP
Granted: February 6, 2014
Application Number:
20140034825
An ion trap includes a trap exit at which an ion energy adjusting device is located. The adjusting device may be configured for focusing a beam of ions ejected from the trap, reducing the energy distribution of the ions, and/or reducing the average kinetic energy of the ions. The adjusting device may include lenses to which RF and/or DC voltages are applied.
MICROFLUIDIC HPLC-CHIP FOR GLYCOPEPTIDE ANALYSIS WITH INTEGRATED HILIC ENRICHMENT
Granted: January 30, 2014
Application Number:
20140030732
A microfluidic device for glycopeptide analysis includes an enrichment column capable of binding carbohydrates; a trapping column capable of binding peptides, wherein the trapping column is configured to be connected downstream of the enrichment column; a separation column, wherein the separation column is configured to be connected downstream of the trapping column; and a plurality of ports configured to work with a switching device to form a plurality of flow paths, wherein one of the…
SAMPLE PROBES AND METHODS FOR SAMPLING INTRACELLULAR MATERIAL
Granted: January 9, 2014
Application Number:
20140011226
A sample probe includes a tip including a distal end for penetrating a cellular membrane, an opening located at or proximal to the distal end, and tip microchannels extending through the tip and communicating with the opening; and a body adjoining the tip and including body microchannels, wherein at least one of the body microchannels communicates with at least one of the tip microchannels. A method for sampling intracellular material includes inserting a probe tip through a cellular…
PASSIVE INTERMODULATION MEASUREMENT APPARATUS
Granted: January 2, 2014
Application Number:
20140002097
A method and apparatus are described for generally passive intermodulation measurement to specify a location and strength of an intermodulation source of a passive component in a transmission line. Beneficially, the apparatus and method are comparatively simple and inexpensive.
SEALED FLUIDIC COMPONENT COMPRISING A COMPOSITE MATERIAL OF DIFFERENT PAEK MATERIALS
Granted: December 26, 2013
Application Number:
20130341260
A sealed fluidic component (280) for use in a fluidic flow path is made by providing a composite material (300) comprising a first material (305) and a second material (310), wherein the first material (305) and the second material (310) are different PAEK materials with the first material (305) having a lower melting point than the second material (310). The composite material (300) is heated in order to provide a sealing by the first material (305).
APPARATUS AND METHOD FOR PROVIDING TIMING ADJUSTMENT OF INPUT SIGNAL
Granted: December 19, 2013
Application Number:
20130335130
An apparatus for providing time adjustment of an input signal includes a coarse timing digital-to-analog converter (DAC), a replica delay element and an interpolator. The coarse timing DAC has multiple delay settings for providing a coarse timing adjustment of the input signal, and outputs a first delayed signal by delaying the input signal by a first delay time corresponding to a selected setting of the multiple delay settings. The replica delay element receives the first delayed signal…
COMPUTATIONAL METHOD FOR MAPPING PEPTIDES TO PROTEINS USING SEQUENCING DATA
Granted: December 19, 2013
Application Number:
20130338932
A method for proteomic analysis of a biological sample is disclosed, which includes obtaining peptide sequences of proteins in a target list; and identifying proteins in the biological sample by mapping the obtained peptide sequences on proteins in a proteomic database, wherein the target list is determined using information of RNA transcripts in the biological sample and/or the target list is determined using information of RNA transcripts in the biological sample. The peptide sequences…
