Control of sample separation based on analysis of mobile phase supply from mobile phase container
Granted: May 6, 2025
Patent Number:
12292420
A method of controlling a sample separation apparatus, for separating a fluidic sample using a mobile phase provided from at least one mobile phase container, includes determining a weight and volume reduction behavior according to which weight and volume of mobile phase in a mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus, and determining a tare weight of the mobile phase container based on a gross…
Optical imaging performance test system and method
Granted: May 6, 2025
Patent Number:
12292352
For testing the imaging performance of an optical system, a test target is positioned at an object plane of the optical system, and illuminated to generate an image beam. One or more images of the test target are acquired from the image beam. From the imaging data acquired, Edge Spread Functions at a plurality of locations within the test target are calculated. A model of Point Spread Functions is constructed from the Edge Spread Functions. Based on the Point Spread Functions, a…
Raman analysis of pharmaceutical dosage forms
Granted: April 29, 2025
Patent Number:
12287289
Methods and apparatus (10) for Raman spectral analysis of a sample (12), such as a pharmaceutical dosage form, are disclosed. Delivery optics (16) are used to deliver probe light to a delivery region (13) on the sample, and collection optics (20) are used to collect, from a collection region (17) on the sample spaced from the delivery region, the probe light following scattering through the sample. Each of a plurality of target Raman spectral features are measured in the collected light,…
Assembly of long nucleic acids by ligation using indexed splint oligos
Granted: April 22, 2025
Patent Number:
12281302
The present disclosure relates to a method of assembling long nucleic acids by enzymatically ligating oligonucleotide molecules hybridized to an indexed splint oligonucleotide molecules. Also disclosed are oligonucleotide structures comprising an indexed splint oligonucleotide useful in performing the disclosed method.
Instrument monitoring system
Granted: April 8, 2025
Patent Number:
12273670
Systems and methods are disclosed for capturing and interpreting data streams between an instrument and a controlling device. A processor is configured to receive a data stream sent by the instrument to the controlling device and identify data frames in the stream. The processor is configured to search for a bit pattern in the stream, identify bits corresponding to a message length of a first presumed data frame based on a location relative to the bit pattern, and identify a second…
Optimized coordination and scheduling of use of equipment and resources within work environment
Granted: April 1, 2025
Patent Number:
12265931
Novel tools and techniques are provided for implementing optimized scheduling of tasks involving equipment used by multiple individuals. In various embodiments, a computing system might receive, from a first user, a first request to use first equipment that is disposed in a work environment, the first request comprising information regarding a first task to be performed using the first equipment. The computing system might determine a core processing time during which the requested first…
Carrier gas connection device for gas chromatographs
Granted: March 25, 2025
Patent Number:
12259371
Carrier gas connection devices (100, 402, 404, 406, 408) enable one to change the carrier gas provided to a gas chromatography channel. The carrier gas connection devices (100, 402, 404, 406, 408) comprise a channel adaptor (102, 202), a carrier block (104, 302), and a clamping system, and two or more channel adaptor positions. In each of the channel adaptor positions, a fluid-tight flow path for carrier gas out of the carrier block (104,302) into the channel adaptor (102, 202) is…
Removing portions of undefined composition from the mobile phase
Granted: February 25, 2025
Patent Number:
12235249
A fluid supply system, for supplying a mobile phase in a sample separation device for separating a fluidic sample in a separation path, includes a proportioning unit for proportioning multiple solvent components for composing the mobile phase, a fluid drive unit for driving the solvent components of the mobile phase, and a control unit for controlling the proportioning unit and the fluid drive unit so that an undefined portion of the mobile phase is removed from the mobile phase before…
Sample injection with fluidic connection between fluid drive unit and sample accommodation volume
Granted: February 25, 2025
Patent Number:
12235248
An injector, for injecting a fluidic sample into a flow path between a fluid drive and a sample separation unit, includes a sample accommodation volume, a sample drive, and a fluidic valve switchable to selectively couple the volume with the flow path or decouple the volume from the flow path. In an injection switching state, the fluid drive, the separation unit and the sample drive are coupled by the valve so that fluid driven by the sample drive and flowing from the volume to the…
Hybridization compositions and methods
Granted: January 28, 2025
Patent Number:
12209276
The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
Raman analysis of pharmaceutical dosage forms
Granted: January 7, 2025
Patent Number:
12188871
There are disclosed methods and apparatus for automatic analysis of pharmaceutical dosage forms. In some aspects a dosage form may be grasped by a gripper which is used to bring the dosage form to a test location and to present the dosage form in a plurality of different alignments between delivery and collection optics. Probe light scattered through the dosage form is collected during each alignment. The collected probe light for the plurality of alignments is then used for Raman…
Fluid processing with withdraw-transfer modulation
Granted: December 24, 2024
Patent Number:
12174160
A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for…
Vacuum pumping system having a plurality of positive displacement vacuum pumps and method for operating the same
Granted: December 24, 2024
Patent Number:
12173712
A vacuum pumping system includes a plurality of positive displacement vacuum pumps, and more particularly a plurality of positive displacement vacuum pumps working in parallel. The vacuum pumping system includes a management unit that carries out a synchronized control of all the positive displacement vacuum pumps of the vacuum pumping system and thus allows to check possible risk of contamination of the vacuum pumping system and carry out, if needed, the necessary corrective actions…
Vacuum pumping system comprising a vacuum pump and its motor
Granted: December 24, 2024
Patent Number:
12173710
A vacuum pumping system includes a vacuum pump and a motor for driving the vacuum pump. A motor stator and a motor rotor are received in a pumping chamber of the vacuum pump. Thanks to such arrangement, the vacuum pumping can be made as a single, sealed unit and the need for dynamic seals can be avoided. Moreover, the vacuum pumping system can be more compact and lighter than prior vacuum pumping systems. A pump rotor of the vacuum pump may be at least partially made as a hollow body,…
Substrate orientation device for liquid dispensing operations
Granted: December 24, 2024
Patent Number:
12172429
A substrate orientation device includes a frame that supports a substrate on which liquid is dispensed, for example as may relate to (bio)chemical microarray fabrication. The frame is movable to different positions, such as for mounting the substrate to the frame, depositing droplets on the substrate, and applying a bulk liquid to the substrate. The substrate orientation device may be movable to different locations, such as different liquid dispensing devices, for example a printer and a…
Pre-shaping fluidic sample in a planar way before processing
Granted: December 24, 2024
Patent Number:
12172162
A method of handling a fluidic sample includes taking fluidic sample from a sample source by a sample shaping tool so that a pre-shaped planar fluidic sample is held by the sample shaping tool with at least one main surface, or both opposing main surfaces, of the pre-shaped planar fluidic sample being exposed, and processing the pre-shaped planar fluidic sample such as by separating the pre-shaped planar fluidic sample in a sample separation device.
Configuring an injector for emulating operation of another injector
Granted: December 10, 2024
Patent Number:
12163932
A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data…
Rocker valve comprising a sealing element
Granted: November 12, 2024
Patent Number:
12140232
A rocker valve for opening or closing a fluid connection includes a valve chamber into which at least one opening feeds, a pivotally mounted rocker switch, and a membrane surface located between the rocker switch and the opening. By pivoting the rocker switch, the opening can be fluidically opened or closed relative to the valve chamber. The rocker valve further includes a sealing element that is located between the membrane surface and the opening when the rocker switch closes the…
Branching off fluidic sample with low influence on source flow path
Granted: November 12, 2024
Patent Number:
12140575
A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within…
Method and system for element identification via optical emission spectroscopy
Granted: November 12, 2024
Patent Number:
12140478
The present invention is directed to a computer-implemented method of automatically identifying the presence of one or more elements in a sample via optical emission spectroscopy. The method includes the steps of obtaining sample spectrum data from the sample, obtaining a list of one or more predetermined emission wavelengths for each element in the periodic table quantifiable by optical emission spectroscopy, each predetermined emission wavelength being associated with a list of one or…
