Hybridization compositions and methods
Granted: January 28, 2025
Patent Number:
12209276
The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
Raman analysis of pharmaceutical dosage forms
Granted: January 7, 2025
Patent Number:
12188871
There are disclosed methods and apparatus for automatic analysis of pharmaceutical dosage forms. In some aspects a dosage form may be grasped by a gripper which is used to bring the dosage form to a test location and to present the dosage form in a plurality of different alignments between delivery and collection optics. Probe light scattered through the dosage form is collected during each alignment. The collected probe light for the plurality of alignments is then used for Raman…
Fluid processing with withdraw-transfer modulation
Granted: December 24, 2024
Patent Number:
12174160
A fluid processing apparatus includes a first fluid processing unit and a second fluid processing unit. A fluid unit is fluidically coupled to the first fluid processing unit and includes a first buffering unit configured for buffering fluid, and/or a mask flow source configured for providing a mask fluid or a flow thereof. A first coupling point is fluidically coupled between the first fluid processing unit and the fluid unit. A modulation unit is configured, selectively, for…
Vacuum pumping system having a plurality of positive displacement vacuum pumps and method for operating the same
Granted: December 24, 2024
Patent Number:
12173712
A vacuum pumping system includes a plurality of positive displacement vacuum pumps, and more particularly a plurality of positive displacement vacuum pumps working in parallel. The vacuum pumping system includes a management unit that carries out a synchronized control of all the positive displacement vacuum pumps of the vacuum pumping system and thus allows to check possible risk of contamination of the vacuum pumping system and carry out, if needed, the necessary corrective actions…
Vacuum pumping system comprising a vacuum pump and its motor
Granted: December 24, 2024
Patent Number:
12173710
A vacuum pumping system includes a vacuum pump and a motor for driving the vacuum pump. A motor stator and a motor rotor are received in a pumping chamber of the vacuum pump. Thanks to such arrangement, the vacuum pumping can be made as a single, sealed unit and the need for dynamic seals can be avoided. Moreover, the vacuum pumping system can be more compact and lighter than prior vacuum pumping systems. A pump rotor of the vacuum pump may be at least partially made as a hollow body,…
Substrate orientation device for liquid dispensing operations
Granted: December 24, 2024
Patent Number:
12172429
A substrate orientation device includes a frame that supports a substrate on which liquid is dispensed, for example as may relate to (bio)chemical microarray fabrication. The frame is movable to different positions, such as for mounting the substrate to the frame, depositing droplets on the substrate, and applying a bulk liquid to the substrate. The substrate orientation device may be movable to different locations, such as different liquid dispensing devices, for example a printer and a…
Pre-shaping fluidic sample in a planar way before processing
Granted: December 24, 2024
Patent Number:
12172162
A method of handling a fluidic sample includes taking fluidic sample from a sample source by a sample shaping tool so that a pre-shaped planar fluidic sample is held by the sample shaping tool with at least one main surface, or both opposing main surfaces, of the pre-shaped planar fluidic sample being exposed, and processing the pre-shaped planar fluidic sample such as by separating the pre-shaped planar fluidic sample in a sample separation device.
Configuring an injector for emulating operation of another injector
Granted: December 10, 2024
Patent Number:
12163932
A configurable injector for injecting a fluidic sample in a separation path of a sample separation apparatus includes a sample accommodation volume for accommodating the fluidic sample to be injected into the separation path, a valve arrangement fluidically couplable with the separation path, fluidically coupled with the sample accommodation volume, and being controllable for injecting the fluidic sample into the separation path, an input interface configured for receiving input data…
Method and system for element identification via optical emission spectroscopy
Granted: November 12, 2024
Patent Number:
12140478
The present invention is directed to a computer-implemented method of automatically identifying the presence of one or more elements in a sample via optical emission spectroscopy. The method includes the steps of obtaining sample spectrum data from the sample, obtaining a list of one or more predetermined emission wavelengths for each element in the periodic table quantifiable by optical emission spectroscopy, each predetermined emission wavelength being associated with a list of one or…
Branching off fluidic sample with low influence on source flow path
Granted: November 12, 2024
Patent Number:
12140575
A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within…
Rocker valve comprising a sealing element
Granted: November 12, 2024
Patent Number:
12140232
A rocker valve for opening or closing a fluid connection includes a valve chamber into which at least one opening feeds, a pivotally mounted rocker switch, and a membrane surface located between the rocker switch and the opening. By pivoting the rocker switch, the opening can be fluidically opened or closed relative to the valve chamber. The rocker valve further includes a sealing element that is located between the membrane surface and the opening when the rocker switch closes the…
Smartphone display screen or portion thereof with transitional graphical user interface
Granted: November 5, 2024
Patent Number:
D1050156
Versatile tube-free jet for gas chromatography detector having a conical inlet skirt
Granted: October 29, 2024
Patent Number:
12130266
A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
Ion guide with varying multipoles
Granted: October 15, 2024
Patent Number:
12119214
An ion guide includes electrodes elongated along an axis from an entrance end to an exit end and spaced around the axis to surround an interior. The electrodes have polygonal shapes with inside surfaces disposed at a radius from the axis and having an electrode width tangential to a circle inscribed by the electrodes. An aspect ratio of the electrode width to the radius varies along the axis. The electrodes are configured to generate a two-dimensional RF electrical field in the interior…
Versatile tube-free jet for gas chromatography detector having a conical inlet skirt
Granted: October 15, 2024
Patent Number:
12117424
A jet injector for a GC that includes a body, a skirt extending away from the body; and a bore that extends through the skirt and the body to create an inlet and an outlet for the jet injector.
Double sided oil film thrust bearing in a scroll pump
Granted: September 24, 2024
Patent Number:
12098642
A vacuum scroll pump having an inlet portion having a pump inlet, and an exhaust portion having a pump outlet; a frame; a stationary scroll plate fixed to the frame and comprising a stationary plate comprising at least one stationary scroll blade; an orbiting scroll plate comprising an orbiting plate comprising at least one orbiting scroll blade projecting axially from a front side of the orbiting plate toward the stationary plate; a drive mechanism supported by the frame and operatively…
Kits comprising aldehydes to reduce artifacts in analyzing glycans released from glycoproteins or glycopeptides
Granted: September 17, 2024
Patent Number:
12092644
The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or glycopeptides.
Adjusting separation method using sensor data and numerical analysis
Granted: September 10, 2024
Patent Number:
12085545
A process of determining a modified separation method for a sample separation apparatus based on an initial separation method, including carrying out the initial separation method on a sample separation apparatus, detecting sensor data at the sample separation apparatus during carrying out the initial separation method, and carrying out a numerical analysis for determining the modified separation method by modifying at least one operation parameter of the initial separation method and by…
Injector serving multiple sample separation apparatuses
Granted: September 3, 2024
Patent Number:
12078619
An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is…
Software licensing management and authentication
Granted: September 3, 2024
Patent Number:
12079313
Novel tools and techniques are provided for implementing software licensing management and authentication. In various examples, a computing system might receive a request for an unlock code for a requested service from a user using a client device on which a first software is executed, the request comprising a generated unique identifier associated with the requested service and/or the first software. The generated unique identifier comprises licensing information associated with the…
