Fitting element with bio-compatible sealing
Granted: April 27, 2021
Patent Number:
10989340
A fitting element is configured for coupling tubing to a fluidic device having a receiving cavity configured for receiving the fitting element, where the tubing has an inner contact surface of a biocompatible material, the inner contact surface being configured to contact a fluid to be conducted by the tubing, and the receiving cavity having a receiving contact surface of a bio-compatible material. The fitting element includes a first sealing element of a bio-compatible material…
Gas chromatography detector jet
Granted: April 27, 2021
Patent Number:
D917321
Sample processing apparatus
Granted: April 20, 2021
Patent Number:
D917063
Corrected flow reporting under dynamic conditions by system modeling
Granted: April 13, 2021
Patent Number:
10976289
To determine a corrected flow rate value of a mobile phase flowing in a liquid chromatography (LC) system, a flow rate of the mobile phase at a selected reference position in the LC system is measured to produce one or more flow rate values. A model of the LC system is applied to the flow rate value(s) to determine the corrected flow rate value(s). The model includes a distribution of capacitive elements and resistive elements arranged according to a topology of the LC system. The…
High-vacuum pump
Granted: April 6, 2021
Patent Number:
10968915
A high-vacuum pump comprises a plurality of pumping stages, each comprising a plurality of mutually cooperating elements, including at least one rotating rotor element and one stationary stator element. At least one of the elements of at least one of the pumping stages is made of a plastic material reinforced with short fibres, dispersed in chaotic and substantially random manner inside the matrix of plastic material. Use of a plastic material reinforced with short fibres allows making…
MHC multimers in borrelia diagnostics and disease
Granted: April 6, 2021
Patent Number:
10968269
Novel compounds carrying ligands capable of binding to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, including use as detection systems, detection of relevant target cells as well as a number of other methods. In particular, novel MHC complexes comprising one or more MHC molecules containing one or more Borrelia derived peptides are disclosed. The…
HPLC sample introduction with bypass channel
Granted: March 23, 2021
Patent Number:
10953345
A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher…
Sample processing apparatus
Granted: March 23, 2021
Patent Number:
D914231
Microtome blade and/or microtome blade holder cleaning using adhesive material
Granted: March 16, 2021
Patent Number:
10946543
The present disclosure related to apparatus and methods for removing waste of debris from a microtome blade, a microtome blade holder, or both. The invention also relates to automated systems and methods for cleaning a microtome.
Antigen detection using photocleavable labels
Granted: March 9, 2021
Patent Number:
10942176
Provided herein are methods of using photocleavable labels for multiplex and serial antigen detection. The methods comprise detecting the presence of photocleavable labels, which are conjugated through functional linkers to antigen-binding complexes, which in turn non-covalently bind to antigens. The presence of a photocleavable label is indicative of the presence of an antigen specifically or selectively bound by an antigen-binding complex. Also provided are apparatuses for using…
Modular mounting system for components of heating chamber
Granted: March 2, 2021
Patent Number:
10933349
An arrangement for mounting components in a heating chamber for heating a fluid of a fluid separation apparatus, wherein the arrangement comprises a mounting board having at least one mounting recess each configured for accommodating at least one component, and the at least one component each configured to be mountable in and/or on the at least one mounting recess.
Preparation of tissue sections using fluorescence-based detection
Granted: February 9, 2021
Patent Number:
10914658
The present disclosure is directed to an improved method for distinguishing tissue from an embedding medium, such as paraffin in a formalin-fixed paraffin-embedded sample. The method involves the use of fluorescence of naturally-occurring species in tissue to determine the location of the tissue in the embedded sample. An embedded sample is generally excited by light of a selected wavelength, and the fluorescence emission at an emitted wavelength is used to locate the boundary or…
Fluidic valve with contactless force transmission for pressing together stator and rotor
Granted: February 9, 2021
Patent Number:
10914394
A fluidic valve for switching between different fluid coupling states includes a stator having at least one fluidic stator interface, a rotor having at least one fluidic rotor interface, wherein the rotor is rotatable relative to the stator to thereby switch the fluidic valve between a plurality of different fluid coupling states between the at least one fluidic stator interface and the at least one fluidic rotor interface, and a force transmission mechanism configured for pressing the…
Guide RNA with chemical modifications
Granted: January 26, 2021
Patent Number:
10900034
The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
Metal components with inert vapor phase coating on internal surfaces
Granted: January 19, 2021
Patent Number:
10895009
The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal…
Multi-temperature optical spectrometer modules, systems and methods of using the same
Granted: January 12, 2021
Patent Number:
10890523
An optical spectrometer module for analysing samples. The optical spectrometer module comprises two or more sample holders. Each sample holder is adapted to receive and reproducibly position a sample in fixed locations within the optical spectrometer module. Each sample holder is also adapted to receive a light beam to thereby enable a sample contained in the sample holder to be exposed to the received light beam. Each sample holder is further adapted to enable light transmitted through…
Full field visual-mid-infrared imaging system
Granted: January 5, 2021
Patent Number:
10887532
An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images.…
Method and device for calibration of biological flux
Granted: January 5, 2021
Patent Number:
10883978
An apparatus for calibrating a flux analyzer comprises a first frame; a second frame; and a permeable membrane. The first frame and the second frame are connected or integrally formed. A method for calibrating a flux analyzer is provided which uses an artificial standard rather than a biological standard.
Precision high voltage power supply utilizing feedback through return side output
Granted: December 22, 2020
Patent Number:
10872753
In one embodiment, a high voltage power supply includes a DC voltage input, a converter for converting a DC voltage at the DC voltage input to an AC voltage, a booster for boosting the AC voltage to a boosted AC voltage, a rectifier in DC isolation from the DC voltage input, the rectifier operable to convert the boosted AC voltage to a high DC voltage at an isolated rectifier output, a high voltage DC output for outputting the high DC voltage, a voltage control input, and an error…
Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios
Granted: December 1, 2020
Patent Number:
10854438
In an inductively coupled plasma-mass spectrometry (ICP-MS) system, ions are transmitted into a collision/reaction cell. A DC potential is applied at an exit of the cell at a first magnitude to generate a DC potential barrier effective to prevent the ions from exiting the cell. The DC potential barrier is maintained during a confinement period to perform an interaction. After the confinement period, analyte ions or product ions are transmitted to a mass spectrometer by switching the exit…
