Adjustable aperture device with integral aperture holes
Granted: October 10, 2017
Patent Number:
9786400
An adjustable aperture device for an electromagnetic radiation detecting apparatus includes a position adjustment body configured for adjusting a position of a selected aperture hole of multiple selectable aperture holes, where electromagnetic radiation propagates through the selected aperture hole. The adjustable aperture device further includes a guide unit configured for guiding the position adjustment body along a predefined guide direction, and an aperture body defining the aperture…
Prevention of phase separation upon proportioning and mixing fluids
Granted: October 10, 2017
Patent Number:
9782692
A fluid supply system configured for supplying fluids includes a fluid packet supply unit configured for controlling supply of a sequence of fluid packets. The fluid packets include a packet of first fluid and a packet of second fluid, wherein the first fluid and the second fluid are media being prone to a phase separation upon direct interaction between the packet of first fluid and the packet of second fluid. The fluid supply system further includes a phase separation inhibiting unit…
Methods for on-array fragmentation and barcoding of DNA samples
Granted: September 26, 2017
Patent Number:
9771575
The present disclosure provides methods for barcoding a plurality of DNA samples using a microarray of barcode-containing transposase complexes. In some embodiments, the DNA samples and transposase complexes are present in aqueous droplets on the surfaces of opposing substrates, which allows a single DNA sample droplet to be combined with a single transposase-complex droplet. The barcoded DNA in the combined droplets can be used for any number of purposes, including as templates for…
Pump testing for predicting lifetime and wear conditions
Granted: September 19, 2017
Patent Number:
9765789
System and method for testing a pump. The testing of the pump includes determining a Mechanical Power Index (MPI) for the pump. The MPI is determined by operating the pump at operating speed for a minimum operating interval. When the pump is stopped under normal operation by the application, the pump speed is continuously monitored. The time when the pump speed decreases to an initial speed close to the operating speed is read as an initial time. When the pump speed decreases to a final…
Method for identifying a nucleic acid in a sample
Granted: September 12, 2017
Patent Number:
9758817
A method of sample analysis is provided. In certain embodiments, the method may comprise: contacting a nucleic acid sample with a first primer and a second primer under PCR conditions to produce a double stranded product, wherein the second primer comprises a first label and is 5? blocked; b) contacting the double stranded product with an exonuclease to degrade one strand of the double-stranded product to produce a single stranded product; c) contacting the single stranded product with a…
Thermostable type-A DNA polymerase mutant with increased resistance to inhibitors in blood
Granted: September 12, 2017
Patent Number:
9758773
The invention provides mutants of DNA polymerases having an enhanced resistance to inhibitors of DNA polymerase activity. The mutant polymerases are well suited for PCR amplification of targets in samples that contain inhibitors of wild-type polymerases.
Micromachined flow cell with freestanding fluidic tube
Granted: September 5, 2017
Patent Number:
9752978
A micromachined flow cell includes a substrate and a freestanding tube, delimiting a fluidic conduit therein and being integrally formed from material of the substrate.
Optical emission system including dichroic beam combiner
Granted: September 5, 2017
Patent Number:
9752933
An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and the second light via a second light path, reflects a portion the first light into an entrance aperture of a light detection and measurement apparatus, and transmits a portion of the second…
Single-piece ferrule with undercut tapering part
Granted: September 5, 2017
Patent Number:
9751085
A single-piece ferrule for a fitting for coupling a capillary to another component of a fluidic device, wherein the ferrule comprises a ferrule body, wherein the ferrule body has a lumen configured for receiving at least a part of the capillary, wherein the ferrule body has a tapering front part configured for forming a sealed connection with a housing of the fitting, wherein a back side of the tapering front part has an annular undercut.
Sample injector with disconnectable injection needle
Granted: August 22, 2017
Patent Number:
9739794
A sample injector for injecting a fluid into a fluidic path, wherein the sample injector comprises a robot arm configured for moving an injection needle, when being connected to the robot arm, between a fluid container containing the fluid and a seat in fluid communication with the fluidic path, the needle configured for aspirating the fluid from the fluid container, when the needle has been moved to the fluid container, and for injecting aspirated fluid into the fluidic path, when the…
Infrared imaging system with automatic referencing
Granted: August 22, 2017
Patent Number:
9739661
A method and apparatus for obtaining reference samples during the generation of a mid-infrared (MW) image without requiring that the sample being imaged be removed is disclosed. A tunable MIR laser generates a light beam that is focused onto a specimen on a specimen stage that moves the specimen in a first direction. An optical assembly includes a scanning assembly having a focusing lens and a mirror that moves in a second direction, different from the first direction, relative to the…
Injection needle cartridge with integrated sealing force generator
Granted: August 15, 2017
Patent Number:
9733221
An injection needle cartridge for a sample injector for injecting a sample fluid into a mobile phase in a fluidic path of a fluid separation system between a mobile phase drive and a separation unit, the injection needle cartridge comprising an injection needle configured for aspirating the sample fluid from a fluid container when the injection needle has been moved to the fluid container, and for injecting aspirated sample fluid into the fluidic path when the injection needle is…
Dendrimeric dye-containing oligonucleotide probes and methods of preparation and uses thereof
Granted: August 15, 2017
Patent Number:
9732113
The invention provides novel oligonucleotide probes that have dendrimeric dyes useful for detecting and analyzing biological samples, and compositions and methods thereof. The dendrimeric dye-containing oligonucleotide probes are useful for high sensitivity fluorescence in situ hybridization (FISH) of nucleic acids such as DNA and RNA.
Synthesizing light fields in microscopy
Granted: August 8, 2017
Patent Number:
9726875
A light field representation of a sample is synthesized or simulated based on bright field image data and phase image data acquired by a microscope such as a quantitative phase microscope. The light field representation may be utilized to render three-dimensional representations of the sample.
Method to generate data acquisition method of mass spectrometry
Granted: July 18, 2017
Patent Number:
9711339
A process for automatically creating a measurement method suitable for plasma ion source mass spectrometry, including: semi-quantitatively measuring all elements in the sample that affect the measurement; determining a plasma condition based on the total concentration of the semi-quantitatively measured elements; for each of the semi-quantitatively measured elements, estimating signal strengths of the element and an interference component in the sample to be measured and based on the…
Passivation of surfaces after ligand coupling
Granted: July 18, 2017
Patent Number:
9709563
Passivated substrates are provided for use in assays, comprising at least one covalently bonded ligand having specific binding activity for a molecule, and at least one covalently bonded blocking agent, wherein said ligand is directly bonded to the substrate surface. In certain embodiments, the ligand and blocking agent are covalently bonded only to the substrate surface, and not directly bonded to each other. In certain other embodiments, the ligand and blocking agent have at least one…
Spiral pumping stage and vacuum pump incorporating such pumping stage
Granted: July 11, 2017
Patent Number:
9702374
A spiral pumping stage includes both centripetal and centrifugal pumping channels, so that the gas is pumped from the periphery to the center of the pumping stage throughout a first group of pumping channels and it is pumped from the center to the periphery of the pumping stage throughout a second group of pumping channels. Thanks to this inventive arrangement, both the gas coming from a previous pumping stage or a main pump inlet arranged upstream the pumping stage according to the…
Two-dimensional fluid separation with controlled pressure
Granted: July 4, 2017
Patent Number:
9694301
A sample separation apparatus for separating a liquid sample includes a first separation unit for separating the sample, a first fluid drive for conducting the sample to be separated through the first separation unit, a second separation unit, arranged downstream of the first separation unit, for further separating the sample, a second fluid drive for at least partially conducting the sample through the second separation unit, and a fluidic valve having interfaces fluidically coupled to…
Nanofluidic device for charge analysis of straightened molecules
Granted: June 20, 2017
Patent Number:
9683958
This disclosure provides, among other things, a nanofluidic device sensing device is provided. In certain embodiments, the device contains: a) a channel comprising a floor and a ceiling, b) an array of charge sensors in the floor and/or ceiling of the channel, arranged along the longitudinal axis of the channel; c) a capture area in the floor and/or ceiling of the channel at the entrance end of the channel; and d) a first electrode and a second electrode, wherein the first and second…
Generating perspective views in microscopy
Granted: June 13, 2017
Patent Number:
9678326
A microscope includes a spatial light modulator configured for adjusting the perspective angle of a view imaged at the light detector. The spatial light modulator is positioned at a pupil plane, or at an equivalent conjugate plane thereof, in the illumination light path or in the detection light path. The microscope enables perspective views of a sample at different angles, which may be utilized to generate a three-dimensional image of the sample.
