Vacuum fired and brazed ion pump element
Granted: June 9, 2015
Patent Number:
9053917
A Vacuum Fired and Brazed (“VFB”) anode array element for use in an ion pump is described. The VFB anode array element includes a first VFB conduit anode element and second VFB conduit anode element, wherein the second VFB conduit anode element is adjacent the first VFB conduit anode element. The first VFB conduit anode element is vacuum brazed together with second VFB conduit anode element.
Multi-channel filter assembly and related apparatus and methods
Granted: June 9, 2015
Patent Number:
9050548
A filter assembly includes a housing and filter elements. The housing includes internal chambers between first and second parallel outside surfaces, fluid inlet bores, and fluid outlet bores. Each internal chamber includes a filter element that partitions the internal chamber into an inlet chamber section and an outlet chamber section. The housing establishes a plurality of fluid flow channels from the inlet bores, through the inlet chamber sections, through the filter elements, through…
Devices and methods for reducing matrix effects
Granted: May 26, 2015
Patent Number:
9040672
Devices and methods are provided for reducing matrix effects in protein precipitated bioanalytical samples comprising: a support, and a sorbent associated with the support capable of binding matrix interfering agents present in the bioanalytical sample, wherein the device further comprises filtering means for removing precipitated protein particles. The filtering means is a size exclusion filter or a polymeric or inorganic monolith having a maximum pore size less than or equal to the…
DNA binding protein-polymerase chimeras
Granted: May 26, 2015
Patent Number:
9040276
The invention relates to compositions and methods directed to chimeric DNA polymerases, which comprise a mutated DNA binding polypeptide domain and a mutated or wild-type DNA polymerase polypeptide domain.
Supporting plate of a device
Granted: May 26, 2015
Patent Number:
9039894
A supporting plate of a device is suggested. The device has at least one component and a housing for at least partly protecting the component. The supporting plate has at least one receiving element adapted for accepting the at least one component of the device in at least one of the following manners: in a form-closed manner, in a force-closed manner. The supporting plate is part of the housing.
Chromatography columns
Granted: May 19, 2015
Patent Number:
9034186
A chromatography column is prepared with a stationary phase comprising a deuterated poly(ethyleneglycol), or other deuterated polymer. Formation of the stationary phase can be performed using exactly the same methodology as used when forming a stationary phase with the equivalent non-deuterated polymer. The deuterated poly(ethyleneglycol), or other deuterated polymer, preferably has increased thermal stability as compared to non-deuterated poly(ethyleneglycol), or equivalent…
Plasma-based photon source, ion source, and related systems and methods
Granted: May 12, 2015
Patent Number:
9029797
A photon source includes a plasma source for generating plasma and a photon guide through which the plasma travels. The photon guide includes an inner surface configured for reflecting photons emitted from the plasma. As the plasma travels through the photon guide, plasma electrons and ions recombine at the inner surface, whereby the predominant species emitted from an outlet of the photon guide are the photons and neutral particles, with few or no plasma electrons and ions being…
Ion deflection in time-of-flight mass spectrometry
Granted: May 12, 2015
Patent Number:
9029763
A time-of-flight mass spectrometry (TOF MS) system includes an ion deflector, ion extractor, a flight tube, and a detector. The deflector may be disposed in the flight tube or outside the flight tube upstream of the extractor. The deflector deflects ions away from a main flight path such that the defected ions are not detected.
Gas chromatograph providing semi-automatic identification of connected sample flow components, and method of operating same
Granted: May 12, 2015
Patent Number:
9027384
A method for semi-automatically generating configuration information for a gas chromatograph uses an identification device reader of the gas chromatograph to 1) determine a presence and location of sample flow component identification devices in or on identification device holders that hold the sample flow component identification devices; 2) read information from sample flow component identification devices held in the identification device holders; and 3) output configuration…
Aspheric lens with integral flange for optical measurement instrument
Granted: April 21, 2015
Patent Number:
D727189
Methods and compositions for DNA fragmentation and tagging by transposases
Granted: April 14, 2015
Patent Number:
9005935
The present invention provides new compositions for transposase-mediated fragmenting and tagging DNA targets. The invention relates to the surprising discovery that use of manganese ions (Mn2+) in transposase reactions improves the transposase reaction. It also relates to the surprising discovery that Mg2+ ions can be used in a transposase reaction with wild-type and/or engineered transposases at levels much higher than previously thought. The invention provides for the use of…
Apparatus for punching and solid phase extraction of dried biological fluid spot and related methods
Granted: April 14, 2015
Patent Number:
9005543
An apparatus for punching and extracting analytes from a dried biological fluid spot includes a tube and a sorbent bed. The tube includes a proximal tube opening, a distal tube opening, and a distal section. The distal section includes a tube wall having a tapered diameter that reduces down to the distal tube opening. The apparatus may also include a tube extension that includes an extension wall having a tapered diameter that reduces from a proximal extension opening to a distal…
System and method for performing tandem mass spectrometry analysis
Granted: March 24, 2015
Patent Number:
8987662
A system for performing tandem mass spectrometry (MS/MS) analysis of a sample includes a mass spectrometer and a processor. The mass spectrometer is configured to perform a mass spectrometry (MS) scan of an ionized sample to provide a mass of an observed peak corresponding to a precursor ion. The processor is configured to perform operations including determining whether the mass of the observed peak matches a mass of at least one of multiple expected peptides on a dynamic watch list,…
Devices obtained by solid state bonding method
Granted: March 10, 2015
Patent Number:
8974916
A method for solid state bonding of a plurality of metallic layers and devices made by that method are disclosed. First and second metallic layers are solid state bonded utilizing a protective coating on the non-bonded surfaces that engage the pressure applying appliance to prevent the surfaces from adhering to the pressure applying appliance and to protect the surfaces from imprinting during the bonding process. The invention can be used to fabricate micro-channel devices with smooth…
Scroll pump having separable orbiting plate scroll and method of replacing tip seal
Granted: February 24, 2015
Patent Number:
8961160
A scroll pump facilitates the installation of a new tip seal between an axial end of the scroll blade of one of inner stationary and orbiting plate scrolls of the pump and the plate of the other of the inner stationary plate and orbiting plate scrolls. To this end, the orbiting plate scroll has a central portion and an outer peripheral portion extending around and seated on the central portion. The outer peripheral portion of the orbiting plate scroll is keyed to and/or fastened to the…
Atmospheric pressure interface with improved ion transfer for spectrometry, and related systems and methods
Granted: February 10, 2015
Patent Number:
8952326
An atmospheric pressure (AP) interface for a spectrometer includes wall for separating an ionization chamber from a reduced-pressure region of the spectrometer, an ion inlet defining an ion path from the ionization chamber to the reduced-pressure region, and a passage defining a gas path from the ionization chamber to a gas outlet external to the reduced-pressure region. The passage may have a greater gas conductance than the ion inlet such that most gas into the passage and not the ion…
Isolation of RNA-protein complexes using cross-linking reagents and oligonucleotides
Granted: February 10, 2015
Patent Number:
8951804
Provided herein is a method of sample analysis. In certain embodiments, the method comprises: a) cross-linking protein of a cell using a first compound to produce a first cross-linked product comprising cross-linked protein, and RNA; b) contacting the first cross-linked product and a second compound under conditions by which an oligonucleotide portion of the second compound hybridizes to the RNA; c) activating a reaction the first and second compound, thereby covalently crosslinking the…
Chromatography column with large diameter end fitting openings
Granted: January 20, 2015
Patent Number:
8936723
A column for use in chromatography, the column having a tube with a bore that can contain a packing medium captured between two porous plugs positioned at opposite ends. End fittings are attached to the tube ends, the end fittings having a duct with a duct opening having a diameter at least as large as the diameter of the tube bore which it faces. The duct opening may be positioned within a recess in spaced apart relation to the porous plugs to prevent the end fitting from contacting the…
Interferometer having multiple scan carriages
Granted: January 13, 2015
Patent Number:
8933406
An interferometer includes a fixed assembly including a base, a beam splitter assembly and a fixed mirror, and a movable assembly including an upper scan carriage, a lower scan carriage and a movable mirror connected to the lower scan carriage. The pair of inner bearing flexures is connected to the base and the upper scan carriage, enabling movement of the upper scan carriage relative to the base, and the pair of outer bearing flexures is connected to the upper and lower scan carriages,…
Ligation method employing eukaryotic tRNA ligase
Granted: January 6, 2015
Patent Number:
8927245
Provided herein is a method of preparing an RNA sample comprising: a) obtaining an RNA sample comprising: i. long RNA molecules that may be unfragmented or fragmented to contain 5?-OH group and a 2?-3?-cyclic phosphate group; and ii. short RNA molecules that comprise a 5? phosphate group and a 3? OH group; and b) contacting the RNA sample with an adaptor comprising either a 2?-PO group and 3?-OH group or a 2?,3?-cyclic phosphate group in the presence of a eukaryotic tRNA ligase, thereby…
