Derivatization of PNGase F released glycans on an HPLC chip
Granted: January 6, 2015
Patent Number:
8927263
A microfluidic device for glycan analysis includes a deglycosylation column comprising a glycosidase attached to a solid support; a tagging column comprising a reactive ester for reaction with an amino group, wherein the tagging column is arranged downstream of the deglycosylation column; an analytical column comprising a stationary phase capable of separating a derivatized glycan; and a plurality of inlet/outlet ports configured to connect with channels on a switching element to form…
Fluidic chip with laminated reinforcing layer for pressure reinforcement
Granted: December 30, 2014
Patent Number:
8920750
A fluidic chip device configured for processing a fluidic sample includes two outer boundary layers, and at least one reinforcing layer arranged between the two outer boundary layers and being at both of its opposing main surfaces laminated with directly adjacent layers to reinforce pressure resistance of the fluidic chip device by the lamination, in which at least a part of the layers of the fluidic chip device includes a hole forming at least a part of a fluidic conduit for conducting…
Thin film with improved temperature range
Granted: December 9, 2014
Patent Number:
8907433
A device and a method of forming the same are disclosed. The device comprises a substrate and a thin film. The substrate is characterized by a first coefficient of thermal expansion. The thin film is attached to a surface of the substrate, and is characterized by a second coefficient of thermal expansion. The thin film includes first and second layers in states of compression, and a third layer in a state of tension, the third layer being positioned between the first and second layers.…
Ion detector response equalization for enhanced dynamic range
Granted: November 18, 2014
Patent Number:
8890086
An ion detection system for detecting ions whose velocity varies during an operating cycle. The ion detection system includes a dynode electron multiplier (e.g., a microchannel plate (MCP)) having a bias voltage input, and a bias voltage source to apply a bias voltage to the bias voltage input of the dynode electron multiplier. With a fixed bias voltage applied to its bias voltage input, the dynode electron multiplier has a gain dependent on the velocity of ions incident thereon. The…
Methods for the synthesis and purification of oligomers
Granted: November 18, 2014
Patent Number:
8889851
A reagent for oligonucleotide synthesis or purification, wherein the reagent has a structure of: X—C—L—H??(Formula A) wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor represented by —Ca—Cb—; L is a hydrocarbyl chain; and H is a terminal alkyne or an activated cyclooctyne. The reagent of Formula (A) can be used in the synthesis and purification of oligonucleotides.
Head space sampling device and method for detecting leaks in same
Granted: November 18, 2014
Patent Number:
8887586
The present invention relates to methods and systems for detecting leaks in a head space sampling device. One exemplary method for detecting leaks in a head space sampling device includes establishing fluid communication between a head space and a pressurization gas conduit. Gas pressure and flow rate are monitored within the pressurization gas conduit during pressurization of the head space. Changes in monitored gas pressure and flow rate are used to evaluate whether a leak exists…
DNA polymerase fusions and uses thereof
Granted: November 11, 2014
Patent Number:
8883454
The present invention discloses methods of using DNA polymerase fusions at high pH in PCR, DNA sequencing and mutagenesis protocols.
Sample preparation device and method utilizing polyamide tube
Granted: November 11, 2014
Patent Number:
8883089
Polyamide sample preparation tubes with a hollow polyamide tube and an extraction medium contained within the tube are utilized in the sample preparation devices. The sample preparation tubes are substantially inert and show little tendency to dissolve or leach contaminants into nonaqueous liquids. The polyamide tubes may be used in preparing samples for analytical procedures such as GC, GC/MS, LC or LC/MS.
Integrated tool for compliance testing within an enterprise content management system
Granted: October 28, 2014
Patent Number:
8874400
Methods, tools, systems and computer readable media for compliance testing instrumentation and/or software. Data from one or more analytical instruments and/or software is converted to a technology-neutral format, which is independent of instrument type, instrument model, instrument manufacturer and data type of the analytical instrument or software from which the data was outputted. Calculations are performed on the converted data to produce one or more outputs, and then selection is…
Superficially porous particles and methods of making and using same
Granted: October 21, 2014
Patent Number:
8864988
Disclosed are porous-shell particles, methods of making the particles, and uses thereof. In one aspect, the porous-shell particles are superficially porous particles.
Radio frequency (RF) ion guide for improved performance in mass spectrometers
Granted: October 14, 2014
Patent Number:
8859961
Ion guides for use in mass spectrometry (MS) systems are described. The ion guides are configured to provide a reflective electrodynamic field and a direct current (DC or static) electric field to provide ion beams that are more spatially confined with a comparatively large mass range.
Systems and methods for providing signal analysis data
Granted: October 14, 2014
Patent Number:
8860400
A method for displaying signal analysis data comprises performing a plurality of sweep operations upon a received signal. With the sweep operations, spectral analysis is performed upon a first frequency band of the received signal. Displays are rendered of data generated from the spectral analysis in the first band and a second band different from the first band simultaneously, and the displays in the first band and the second bands are updated according to the sweep operations.
Scanning system with interchangeable optical cartridges for fluorescence measurements
Granted: October 14, 2014
Patent Number:
8858886
The fluorescence measurement system includes a host apparatus and a self-contained, multichannel optical cartridge. The host apparatus includes a well plate receptacle, and a stage having optical cartridge receptacles that are elongate along one axis of the well plate. The stage and the well plate receptacle are movable relative to one another in the direction of the other axis of the well plate. The optical cartridge engages with the optical cartridge receptacle and includes a linear…
Method, a device and a system for executing an action at a predetermined time
Granted: October 7, 2014
Patent Number:
8854924
A method of executing an action at a predetermined time by a device is disclosed. The device has a latency time between initiation of the execution of the action and the actual execution of the action. The method includes advancing the initiation of the execution of the action by the latency time. A device in which the method is implemented and a system including the device are also disclosed.
Calibrating reconstructed signal using multi-tone calibration signal
Granted: September 30, 2014
Patent Number:
8849602
A method of calibrating a reconstructed signal from a plurality of sub-signals is provided. The method includes injecting a calibration signal having multiple tones into a received input signal; dividing the input signal into a first and second sub-signal, including an overlapping frequency band; performing a first frequency translation by converting frequency components of the second sub-signal; digitizing the first sub-signal and the frequency converted second sub-signal; performing a…
Multi-path broadband amplifier
Granted: September 30, 2014
Patent Number:
8847687
An amplifier device having an extended bandwidth includes a DC coupled amplifier and multiple low noise amplifiers connected in series with one another and connected in parallel with at least a portion of the DC coupled amplifier. The DC coupled amplifier has a broad bandwidth, and each of the low noise amplifiers has a narrow bandwidth and a center frequency higher than a high end frequency of the broad bandwidth of the DC coupled amplifier. The extended bandwidth of the amplifier…
Dynamic linearity corrector for digital-to-analog converters
Granted: September 23, 2014
Patent Number:
8842033
A predistortion generator includes a sample input, a summing circuit to output predistorted samples to a DAC, and distortion term processors, each including a product generator and a FIR filter in tandem. The distortion term processors include a second-order and/or a third-order distortion term processor. In the second-order distortion term processor, the product generator generates a product of only two samples corresponding to a current sample as a respective second-order distortion…
System and method for interactive instrument operation and automation
Granted: September 23, 2014
Patent Number:
8843841
A system and method: provide a user interface to a user, the user interface including one or more objects representing a corresponding one or more instruments that are connected to the system; receive from a user a selection of one of the one or more instruments, made via the user interface; obtaining at the computer a file that describes commands to which the selected instrument responds; and present to the user via the user interface an indication of the commands to which the selected…
Measurement data management with combined file database and relational database
Granted: September 23, 2014
Patent Number:
8843437
A device for managing a plurality of measurement data, each measurement data representing a value of a physical parameter, the device comprising a file database adapted for storing the plurality of measurement data in the form of data files each of which being assigned to a specific measurement, a relational database adapted for storing at least a part of the plurality of measurement data in the form of relational data being structured in accordance with individual measurement parameters…
Trigger event detection apparatus and method therefor
Granted: September 23, 2014
Patent Number:
8843336
A method of detecting a trigger event includes receiving an input signal for analysis. The received input signal is used to generate first data corresponding to sequential sets of spectral output data sets, at least some of the spectral output data sets corresponding to sample points in time acquired from the input signal as the input signal changes with time. At least part of the first data is then compared with second data, the second data corresponding to a predetermined sequential…
