Dual material approach for high pressure bioinert flow path components
Granted: January 18, 2022
Patent Number:
11226316
A method of manufacturing a component having a flow path, wherein the method includes forming a high pressure resistant casing with a cavity therein, inserting a body of bioinert material into the cavity to thereby form a composite block, and further processing the composite block for at least partially forming the flow path defined by the component.
Electron capture dissociation (ECD) utilizing electron beam generated low energy electrons
Granted: January 4, 2022
Patent Number:
11217437
Electron capture dissociation (ECD) is performed by transmitting an electron beam through a cell along an electron beam axis, generating plasma in the cell by energizing a gas with the electron beam, and transmitting an ion beam through the interaction region along an ion beam axis to produce fragment ions. Generating the plasma forms an interaction region in the cell spaced from and not intersecting the electron beam, and including low-energy electrons effective for ECD. The ion beam…
Fitting for elastically-biasing a capillary for a fluidtight connection to a fluidic conduit
Granted: January 4, 2022
Patent Number:
11213767
A fitting for providing a fluid connection between a capillary and a fluidic conduit of a fluidic component, the fitting comprising a male piece and a female piece for connection with the male piece, wherein the male piece comprises a housing with a capillary reception configured for receiving the capillary, wherein a part of the capillary being received in the capillary reception is circumferentially covered by a sleeve, an elastic biasing mechanism being arranged at least partially…
Immobilizing fluidic sample for inhibiting spatial broadening
Granted: December 28, 2021
Patent Number:
11209389
A method of handling a fluidic sample in a sample separation device includes at least partly immobilizing the fluidic sample by an immobilizing agent inhibiting spatial broadening of the fluidic sample, and subsequently at least partly releasing the fluidic sample from the immobilizing agent.
Spectrophotometer calibration methods and systems
Granted: November 23, 2021
Patent Number:
11181422
A method of calibrating a spectrophotometer comprising a flash lamp. The method comprises receiving light from the flash lamp at a monochromator of the spectrometer, wherein the flash lamp is a short arc noble gas flash lamp with transverse or axially aligned electrodes; configuring the monochromator to progressively transmit the received light at each of a plurality wavelengths of a selected range of wavelengths, wherein the range of wavelengths is associated with a wavelength feature…
Mid-infrared scanning system for analyzing particulates
Granted: November 16, 2021
Patent Number:
11175212
An apparatus and method for analyzing particulates in a sample is disclosed. The method includes placing the sample on a moveable stage in an apparatus having a tunable MIR light scanner and a visible imaging system, the stage moving between the MIR light scanner and the visible imaging system, providing a visible image of the sample, and receiving user input as to a region of the sample that is to be analyzed. The sample is then moved to the MIR light scanner, the MIR light scanner…
Method and system for estimating a gender of a foetus of a pregnant female
Granted: October 26, 2021
Patent Number:
11155854
A method for estimating a gender of a foetus of a pregnant female, said method comprising measuring allele presences (DX) for a first plurality of genetic markers of the X-chromosome and allele presences (DR) for a second plurality of genetic markers of at least one reference chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a pregnant female; based on said measured allele presences for said first plurality, determining a first fraction thereof which is…
Filters for liquid flow based devices and systems
Granted: October 19, 2021
Patent Number:
11150225
A filter includes an inlet side, an outlet side, and a body. The body includes a first substrate that includes an array of inlet holes passing through the first substrate, and a second substrate that includes an array of outlet holes passing through the second substrate. The body further includes an intermediate region that includes a plurality of channels extending along a plane that is transverse or at an angle to a main axis of the filter. Each channel communicates directly or…
Interface device between sample separation device and mass spectrometer having multiple sample capillaries
Granted: October 19, 2021
Patent Number:
11152200
An interface device, for providing a fluidic interface between a sample separation device and a mass spectrometer, includes an emitter capillary and a plurality of sample capillaries. The sample capillaries are movably arranged within the emitter capillary for transferring fluidic sample from the sample separation device to the mass spectrometer.
Multipole ion optic assembly
Granted: October 19, 2021
Patent Number:
11152199
An ion optic assembly includes a set of conductive rods, a first insulator, and a second insulator. The rods are inserted into through-holes of the first insulator, which are arranged about an axis along which the rods are elongated. The rods are then inserted through a bore of the second insulator and become located in notches of the bore, which are arranged about the axis. Accordingly, the first insulator positions one end of the rods at a first distance from the axis, and the second…
User interface configured to facilitate user annotation for instance segmentation within biological samples
Granted: October 12, 2021
Patent Number:
11145058
Novel tools and techniques are provided for implementing digital microscopy imaging using deep learning-based segmentation via multiple regression layers, implementing instance segmentation based on partial annotations, and/or implementing user interface configured to facilitate user annotation for instance segmentation. In various embodiments, a computing system might generate a user interface configured to collect training data for predicting instance segmentation within biological…
Quick lock connector for connecting a capillary to a fluidic conduit of a fluidic component
Granted: October 5, 2021
Patent Number:
11137378
A fitting for providing a fluid connection between a capillary and a fluidic conduit of a fluidic component, wherein the fitting comprises a capillary reception configured for receiving the capillary, a force applicator configured for being operable to apply a fixing force for fixing the capillary within the fitting, a force limitation mechanism configured for limiting the fixing force being applicable by the force applicator to the capillary, a force splitter configured for splitting…
Hybridization compositions and methods
Granted: September 14, 2021
Patent Number:
11118226
The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, utilize a of cyclic and/or non-cyclic solvent that is non-toxic and may eliminate or reduce the amount of formamide in the hybridization composition.
Hybridization compositions and methods
Granted: September 14, 2021
Patent Number:
11118214
The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
Methods, kits and compositions pertaining to the suppression of the detectable probe binding to randomly distributed repeat sequences genomic nucleic acid
Granted: September 7, 2021
Patent Number:
11111525
This invention is directed to methods, kits, non-nucleotide probes as well as other compositions pertaining to the suppression of binding of detectable nucleic acid probes to undesired nucleotide sequences of genomic nucleic acid in assays designed to determine target genomic nucleic acid.
Use of quaternary and tertiary ammonium cations to denature proteins
Granted: September 7, 2021
Patent Number:
11111268
Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation. Ammonium cation detergents with sulfate or sulfonate anions are particularly useful.
Spectrophotometer
Granted: September 7, 2021
Patent Number:
D929881
Phosphorous protecting groups and methods of preparation and use thereof
Granted: August 31, 2021
Patent Number:
11104699
Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased…
Use of bispyridines to improve labeling of nucleophiles
Granted: August 17, 2021
Patent Number:
11092595
Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.
ICP spectroscopy torch with removable one-piece injector
Granted: August 10, 2021
Patent Number:
11089669
A torch for use in analytic instruments includes a tube subassembly with substantially cylindrical nested inner and outer tubes with coincident central axes, the inner tube having a terminus. The torch also includes a removable injector extending at least partially in the inner tube and having an alignment feature, an inlet, an outlet, and a central axis that is coincident with the central axes of the inner and outer tubes, a seal having a channel for accommodating a portion of the…
