Cepham derivatives
Granted: February 19, 1991
Patent Number:
4994454
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be carried out with or without isolating the intermediate phosphonium cephem compounds. The 3-methylene and 3-halomethylene cephem derivatives and in particular the 1-oxo and 1,1-dioxo cephem compounds are also prepared by reducing a 3-halomethyl-3-cephem…
Process for the purification of serum albumin
Granted: February 5, 1991
Patent Number:
4990447
Recombinantly produced serum albumin is purified in a series of steps, initially employing an alkaline precipitation, optionally followed by incubation with an anion exchange absorbent, followed by affinity chromatography employing a hydrophobic solid phase and using a water-soluble lipid anion as desorbens in the aqueous phase.
Process for the preparation of 3-exomethylene cepham derivatives
Granted: January 15, 1991
Patent Number:
4985554
A process is provided for the preparation of 3-methylene and 3-halomethylene cepham derivatives via 3-phosphoniomethyl-3-cephem derivatives, which in turn can be prepared from 3-halomethyl-3-cephem derivatives. The preparation can be carried out with or without isolating the intermediate phosphonium cephem compounds. The 3-methylene and 3-halomethylene cepham derivatives and in particular the 1-oxo and 1,1-dioxo cepham compounds are also prepared by reducing a 3-halomethyl-3-cephem…
Process for producing 4-(2-methoxyethyl)-phenyl-glycidyl ether and/or metoprolol
Granted: September 11, 1990
Patent Number:
4956284
A process for the preparation of metoprolol in a stereospecific form or a non-toxic, pharmaceutically acceptable acid addition salt thereof and/or a stereospecific form of 4-(2-methoxyethyl)-phenyl glycidyl ether which comprises subjecting 4-(2-methoxyethyl)-phenyl allyl ether to the action of a microorganism having the ability for stereoselective epoxidation of 4-(2-methoxyethyl)-phenyl allyl ether into 4-(2-methoxyethyl)-phenyl glycidyl ether having at least 80% by weight the S…
Process for the preparation of S-2,2-R.sub.1,R.sub.2 -1,3 -dioxolane-4-methanols
Granted: September 11, 1990
Patent Number:
4956285
A process for the preparation of an enriched S-isomer of a 2,2-R.sub.1,R.sub.2 -1,3-dioxolane-4-methanol of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 6 carbon atoms or taken together with the carbon atom to which they are attached form a carbocyclic ring of 3 to 6 carbon atoms comprising subjecting a mixture of R and S isomers of formula I to the action of a microorganism or a substance derived…
Pharmaceutical compositions and process for their preparation
Granted: September 11, 1990
Patent Number:
4956386
A process for producing an effective anti-ulcer preparation in the form of a dry powder by spray-drying a colloidal solution comprising bismuth citrate, ammonia and a polyhydric alcohol.
Pharmaceutical tablet, pharmaceutical granulate and process for their preparation
Granted: August 21, 1990
Patent Number:
4950484
A pharmaceutical tablet containing an amphoteric beta-lactam antibiotic, microcrystalline or micro fine cellulose or a mixture of both and a second disintegrant, being low-substituted hydroxypropylcellulose, which fully disintegrates in water within 60 seconds. When swallowed it shows a bioavailability as good as a pharmacy prepared suspension of the antibiotic. The tablet is compressed from a mixture containing a new granulate which is prepared from the antibiotic substance,…
Method for determination of the presence of antibiotics
Granted: August 7, 1990
Patent Number:
4946777
The presence or absence of residues of an antibiotic such as penicillin is rapidly determined in a sample such as milk or meat. The sample is added to a test vessel containing a solidified agar medium containing spores of a microorganism which has high sensitivity for the antibiotic being determined. After addition of nutrients and incubation, presence or absence of the antibiotic is indicated by the extent of growth of the microorganism. The nutrients may be in the form of a tablet…
Kluyveromyces as a host strain
Granted: July 24, 1990
Patent Number:
4943529
Kluyveromyces hosts and DNA expression cassettes for use in Kluyveromyces are provided for transcription of endogenous and/or exogenous DNA, and production of peptides, for enhancing production of an endogenous product, or producing an exogenous product. The Kluyveromyces hosts find particular use for secretion of a desired peptide product, where signal sequences may be native to the peptide or provided from endogenous or exogenous signal sequences, including synthetic sequences,…
Novel lipolytic enzymes and their use in detergent compositions
Granted: June 12, 1990
Patent Number:
4933287
Novel lipolytic enzymes having an optimum pH in the range of 8 and 10.5 which exhibits effective lipase activity in an aqueous solution containing a detergent at a concentration of up to about 10 g/l under washing conditions at a temperature of 60.degree. C. or below and at a pH between 7 and 11. These lipases are useful in washing compsitions, premixes and enzymatic detergent additives. They are obtainable from bacteria strains selected from Psedomonas pseudoalcaligenes, Pseudomanas…
Process for the preparation of cephem compounds
Granted: May 1, 1990
Patent Number:
4921954
Process for the preparation of 7.beta.-amino-3-substituted methyl-3-cephem-4-carboxylic acid derivatives, new intermediates comprising 7.beta.-(cyclo)alkylideneammonio-3-halomethyl-3-cephem-4-carbox ylic acid derivatives and 7.beta.-amino/ammonio-3-bromomethyl-3-cephem-4-carboxylic acid derivatives and the processes for the preparation of these intermediates.
Process for the preparation of N-(sulfonylmethyl) formamide compounds
Granted: May 1, 1990
Patent Number:
4922016
N-(sulfonylmethyl)formamides are obtained by reacting a sulfinic acid, formaldehyde and formamide in the presence of a second acid and a controlled amount of water. The formamides can be converted to the corresponding sulfonylmethylisocyanides.
Process for the preparation of 9(11)-dehydro steroids
Granted: April 17, 1990
Patent Number:
4917827
9(11)-dehydroandrostanes and 9(11)-dehydropregnanes are prepared by dehydrating the corresponding 9-alpha-hydroxy steroid in the presence of a Lewis acid. The corresponding 8(9)-dehydro-isomer was not detectable. The resulting products are valuable intermediates in steroid synthesis especially in the preparation of corticosteroids.
Meta-containing enolate compounds
Granted: February 6, 1990
Patent Number:
4898955
Trans-.beta.-lactams are prepared in a nearly quantitative yield by a condensation reaction of a new intermediate metal enolate and an appropriate imine. Certain new metal enolates are provided as intermediates.
Process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula
Granted: December 12, 1989
Patent Number:
4886750
A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula ##STR1## or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R.sub.1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in…
Cloning system for Kluyveromyces species
Granted: August 22, 1989
Patent Number:
4859596
A new cloning system is described capable of expressing genetic material derived from recombinant DNA material, which comprises a yeast of the genus Kluyveromyces as a host. Suitable vectors are e.g. vectors containing autonomously replicating sequences (ARS) and vectors containing homologous Kluyveromyces DNA acting as a site for recombination with the host chromosome. New and preferred vectors are those containing ARS sequences originating from Kluyveromyces (KARS vectors). The…
Bismuth containing composition and method for the preparation thereof
Granted: January 31, 1989
Patent Number:
4801608
A new solid bismuth containing composition which is colloidally soluble in water is obtained by spray drying an aqueous ammoniacal colloidal solution of bismuth citrate. The new composition is effective for the treatment of peptic ulcers.
Novel pharmaceutical tablets
Granted: September 27, 1988
Patent Number:
4774083
Novel tablets comprising (a) 80 to 98% by weight of a mixture of trimethoprim and/or an acid addition salt thereof and a sulfonamide and/or a salt thereof in a weight ratio of 1:20 to 20:1 and (b) a pharmaceutically acceptable synthetic ion exchange resin having improved disintegration times and other properties and a process for their preparation.
Inactivated infectious bronchitis vaccine for poultry
Granted: August 2, 1988
Patent Number:
4761282
Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemoilogy under the numbers CNCTC AO 17/81 and CNCTC AO18/82 and at the Collection Nationale de Cultures de Microorganismes d'Institut Pasteur, under Nos. I-168…
Production of beer
Granted: May 24, 1988
Patent Number:
4746517
A process for improving the filterability of wort or beer comprising treating said wort or beer with an enzymatic product produced by Disporotrichum dimorphosporm exhibiting xylanase activity in an amount effective to improve the filterability.
