Cooling device
Granted: April 14, 1981
Patent Number:
4261183
A device for solidifying a layer of a liquid that solidifies upon cooling, such as agar, the liquid being contained in a row of petri-dishes or the like. The device utilizes a horizontally rotatable disc for receiving the dishes, a mechanism for supplying dishes to the disc, and a mechanism for removing the dishes, with solidified liquid, from the disc. A cooling mechanism is positioned below the disc to cool the disc and thereby cool the dishes. A mechanism is provided for slowly…
Preparation of .beta.-lactams and intermediates therefor
Granted: April 7, 1981
Patent Number:
4260743
Novel process for the preparation of .beta.-lactams of the formulae: ##STR1## wherein R' represents lower alkyl, aryl or aryl (lower alkyl), R" represents hydrogen or lower alkyl or R' and R" together with the carbon atoms to which they are attached represent lower cycloalkyl, R'" represents lower alkyl or a group --OR, wherein R represents lower alkyl, X.sub.1, Y.sub.1 and Z.sub.1 are hydrogen or selected organic radicals and R.sub.1 represents an acyl group; which successively involves…
Controlled release composition and process for preparing same
Granted: January 13, 1981
Patent Number:
4244941
Solid constant release composition wherein (a) the solution of soluble core substance within the core space remains saturated during dissolution and (b) the shape and (c) the surface of the coating and (d) the diffusion path for the soluble core substance through the porous coating remains constant while the composition is in a liquid medium, which composition is very useful in media in which constant release during substantially the whole release period is desired, for example, for…
Novel enzyme particles and their preparation
Granted: December 30, 1980
Patent Number:
4242219
A novel process for preparing non-dusting, enzyme-containing particles, e.g. for introduction into washing compositions, comprising homogeneously mixing an amount of an enzyme in dry or substantially dry form to give the desired enzyme activity in the particles when formed, about 20% to about 60% of a hydrophilic organic cohesive compatible with the enzyme, about 10% to about 60% of a building agent suitable for use in enzyme compositions, and a sufficient amount of water, if necessary,…
Active dried baker's yeast
Granted: August 12, 1980
Patent Number:
4217420
An active dried bakers' yeast is prepared with a dry matter content of at least 85% by weight, a protein content (%N.times.6.25) of 45 to 60% based on dry matter and an activity value of 420 to 600, when determined according to test method B.sup.2 as defined in the specification. The yeast has the advantages that it can be added as such to the flour prior to dough-making without preliminary soaking, and it is capable of better gas production than active dried yeasts hitherto available.
19 Hydroxy prostaglandins
Granted: May 27, 1980
Patent Number:
RE30287
Novel 18 -, 19 - and 20 -hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a --CH.sub.2 CH.sub.2 -- or a cis --CH.dbd.CH-- group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the hydroxyl groups…
N-Benzhydryloxyethyl-N-phenylpropyl-piperazines
Granted: May 13, 1980
Patent Number:
4202896
Piperazine derivatives of the general formula ##STR1## wherein R.sub.1 -R.sub.9 are the same or different and each represents a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is 2 or 3 and X represents a group (CH.sub.2).sub.m (in which m is 1, 2, 3 or 4) or a group --CH.sub.2 --CH.dbd.CH--, having methylene linked to the piperazine group, and acid addition and quaternary ammonium salts thereof, are described.The compounds exhibit a strong specific dopaminergic…
Prostaglandin derivatives
Granted: February 26, 1980
Patent Number:
4190670
Novel 18.xi.-, 19.xi.- and 20.xi.-hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a --CH.sub.2 CH.sub.2 -- or a cis --CH.dbd.CH-- group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the…
Preparation of 3-bromomethyl-3-cephem sulfoxides
Granted: January 8, 1980
Patent Number:
4182870
An improved process for the preparation of 3-bromomethyl-3-cephem sulfoxide derivatives of the formula ##STR1## wherein R.sub.1 is an acylamido group and R.sub.2 is a group protecting the carboxy radical which are valuable intermediates for the preparation of various therapeutically useful cephalosporanic acid derivatives.
Process for the preparation of hydroxyphosphinylureidobenzylpenicillins
Granted: December 4, 1979
Patent Number:
4177189
An improved process for the preparation in high yields of a compound of the formula ##STR1## wherein R is an optionally substituted phenyl group, Y is selected from the group consisting of Me and a hydrocarbon, Me is a metal cation and E is selected from the group consisting of hydrogen and a metal cation comprising reacting a compound of the formula ##STR2## wherein Q is selected from the group consisting of hydrogen and a silyl protecting group, Rz is an optionally substituted phenyl…
Prostaglandin derivatives
Granted: August 14, 1979
Patent Number:
4164446
Novel 18.xi.-, 19.xi.- and 20.xi.-hydroxy-prostaglandin derivatives of the formula I ##STR1## wherein the dotted line in the position 8-12 indicates the optional presence of a double bond, the waved lines in position 15 indicate that the hydroxyl group and the group R.sub.4 are either in .alpha.- or .beta.-position and Z represents a --CH.sub.2 CH.sub.2 -- or a cis --CH.dbd.CH--group, and wherein R represents one of the groups: ##STR2## (wherein the waved lines indicate that the hydroxyl…
Antibacterial 1,2,4-oxadiazolylacetamido cephalosporins
Granted: July 10, 1979
Patent Number:
4160829
1,2,4-Oxadiazolylacetic acid derivatives. The derivatives include penicillin and cephalosporin amides which have antibiotic properties.
Fermentation process
Granted: May 22, 1979
Patent Number:
4155813
Fermentation process, e.g. for the production of an oxidation product such as vinegar, which comprises continuously cultivating a bacterial strain, preferably in a vessel of elongated shape, in a medium containing the substrate to be fermented in the presence of a hydrous oxide of a metal selected from the group consisting of titanium, vanadium, zirconium, iron and tin and a chelated polyhydroxy support. The bacterial strain used in the process is preferably chelated or complexed with…
Analgesic imidazolemethanols
Granted: May 1, 1979
Patent Number:
4152441
.alpha.,.alpha.-Diarylimidazole-2-methanols of the general formula ##STR1## wherein R.sub.1 -R.sub.10 are the same or different and each represents a hydrogen or halogen atom or a trifluoromethyl or tertiary butyl group, with at least one of said R.sub.1 -R.sub.10 being halogen, trifluoromethyl or tertiary butyl; R.sub.11 and R.sub.12 are the same or different and each represents a hydrogen atom, an alkyl group, a phenyl group or a halogen-or trifluoromethyl-substituted phenyl group; and…
Catheter holding device
Granted: April 17, 1979
Patent Number:
4149535
A catheter holding device having longitudinally-extending walls defining an open-ended body with a main passage therethrough. At least a portion of the main passage is aligned with openings in forward and rear ends of the body. The portion of the walls adjacent the opening in the forward end of the body is adapted for receipt within a blood vessel or cavity. Another portion of the walls has a side opening allowing communication with the main passage. A side tube encompasses the side…
Antifungal preparations
Granted: April 10, 1979
Patent Number:
4148891
An antifungal preparation to be used in and on agricultural products such as fruit, vegetables, tubers, root-tubers, flower bulbs and rootstocks comprising an amount of polyene antibiotic, peferably natamycin, effective to prevent or inhibit mold growth on the agricultural products dissolved in a mixture of a lower alkanol, such as ethyl alcohol, and a lower alkanoic acid, such as acetic acid and agricultural products treated with this preparation and the method of treatment by…
Antifungal compositions and method
Granted: January 2, 1979
Patent Number:
4132777
Antifungal compositions useful for the treatment of ringworm and other fungal infections comprising an antifungally effective amount of natamycin and a non-toxic, pharmaceutically acceptable organic acid compound and a suitable liquid carrier which compositions may be sprayed onto the animal, applied by a sponge or by other topical administration and concentrate comprising natamycin and the non-toxic, pharmaceutically acceptable organic acid compound in dry form.
A-norandrostane derivatives
Granted: December 19, 1978
Patent Number:
4130665
Therapeutically useful A-nor-androsta-3(5),16-dien-2-one derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom or a methyl group, process for their preparation by dehydrating in the 16-17 position a corresponding 17-hydroxy compound, and pharmaceutical compositions for the treatment of dermatological disorders, which comprise, as an active ingredient at least one of the A-nor-steroids as defined by formula I, are disclosed.
6-(D-.alpha.-Amino-p-hydroxyphenylacetamido)-penicillanic acid preparation
Granted: December 5, 1978
Patent Number:
4128547
A process for the preparation of 6-(D-.alpha.-amino-p-hydroxyphenylacetamido)-penicillanic acid or amoxicillin by reacting 6-aminopenicillanic acid with at least two equivalents of a silylating agent producing trimethylsilyl groups in an anhydrous, inert, water-insoluble organic solvent and reacting the resulting product at a temperature below -25.degree. C with an at least equimolar amount of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.7 are lower alkoxy, R.sub.2 is…
16-Dehydro steroids of the androstane series
Granted: February 21, 1978
Patent Number:
4075233
Therapeutically useful 16-dehydro-androstane derivatives of the general formula: ##STR1## processes for their preparation and pharmaceutical compositions for the treatment of dermatological disorders, which contain as active ingredient at least one of the 16-dehydro-androstane derivatives as defined by the above formula.
