Human immunodeficiency virus neutralizing antibodies
Granted: May 23, 2023
Patent Number:
11655285
The present invention provides novel anti-HIV antibodies with improved therapeutic properties, related pharmaceutical compositions, and methods of use thereof.
Solid forms of a Cot inhibitor compound
Granted: May 23, 2023
Patent Number:
11655237
Disclosed are solid forms of a Cot (cancer Osaka thyroid) inhibitor and corresponding methods of preparation thereof, wherein the Cot inhibitor has the following formula:
Blister pack
Granted: May 9, 2023
Patent Number:
D985397
MCL-1 inhibitors
Granted: May 9, 2023
Patent Number:
11643400
The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
Nucleoside phosphoramidate prodrugs
Granted: May 9, 2023
Patent Number:
11642361
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
Blister pack
Granted: May 9, 2023
Patent Number:
D985398
Blister pack
Granted: May 9, 2023
Patent Number:
D985397
MCL-1 inhibitors
Granted: May 9, 2023
Patent Number:
11643400
The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
Nucleoside phosphoramidate prodrugs
Granted: May 9, 2023
Patent Number:
11642361
Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.
Blister pack
Granted: May 9, 2023
Patent Number:
D985398
Antibodies to matrix metalloproteinase 9
Granted: April 25, 2023
Patent Number:
11634505
The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).
Methods of preparing 1?-cyano nucleosides
Granted: March 28, 2023
Patent Number:
11613553
The present disclosure generally describes methods of preparing 1?-cyano nucleosides, such as a compound of Formula (I). For example, the compound of Formula (I) can be prepared from a compound of Formula (II-a) in a flow reactor.
Substituted pyridotriazine compounds and uses thereof
Granted: March 28, 2023
Patent Number:
11613546
The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.
Multispecific antibodies that target HIV GP120 and CD3
Granted: March 7, 2023
Patent Number:
11597759
Multispecific antibodies (e.g., bispecific antibodies) that bind to HIV gp120 and CD3 are disclosed. Also disclosed are methods of using such antibodies to treat or prevent HIV infection.
Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy) (phenoxy) phosphoryl)amino)propanoate
Granted: March 7, 2023
Patent Number:
11597742
The present invention relates to novel salts and crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate for use in treating viral infections. In some embodiments, the viral infection is caused by a virus selected from the group consisting of Arenaviridae, Coronaviridae, Filoviridae, Flaviviridae, and Paramyxoviridae.
Blister pack packaging blank
Granted: February 28, 2023
Patent Number:
D979401
LPA receptor antagonists and uses thereof
Granted: February 21, 2023
Patent Number:
11584738
The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD), or chronic kidney disease (CKD).
Methods of treating a retroviral infection
Granted: February 21, 2023
Patent Number:
11583581
The invention relates to a non-coding sequence of deoxyribonucleic acids comprising at least one sequence motif N1N2CGN3N4, wherein N is a nucleotide comprising A, C, T, or G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxy-thymidine for the treatment of viral infections. In particular, the non-coding sequence of deoxyribonucleic acids is used in combination with antiretroviral therapy and/or histone de-acetylase inhibitors.
Solid forms of a toll-like receptor modulator
Granted: February 21, 2023
Patent Number:
11583531
The present disclosure provides crystalline forms, solvates and hydrates of (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol, and methods of making.
Compounds for inhibition of ?4 ?7 integrin
Granted: February 14, 2023
Patent Number:
11578069
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), therapeutic methods for treating inflammatory disease.
