Antibodies and fragments thereof that bind hepatitis B virus protein X
Granted: February 14, 2023
Patent Number:
11578117
Provided herein are, inter alia, antibodies, antigen-binding antibody fragments, cells, polynucleotides, compositions, kits, and methods relating to the detection of HBV protein X (HBx), e.g., in vitro and in vivo. Included are antibodies and fragments thereof that bind HBx, as well as kits, cells, and compositions comprising such antibodies and fragments.
Compounds for inhibition of ?4 ?7 integrin
Granted: February 14, 2023
Patent Number:
11578069
The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing compounds of Formula (I), therapeutic methods for treating inflammatory disease.
Pyrrolo[1,2-b]pyridazine derivatives
Granted: February 7, 2023
Patent Number:
11572362
A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof are disclosed.
PD-1/PD-L1 inhibitors
Granted: January 17, 2023
Patent Number:
11555029
Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.
Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use
Granted: January 10, 2023
Patent Number:
11548902
Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2, L, W1, W2, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Substituted 1,4-methanopyrido[1?,2?:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections
Granted: January 10, 2023
Patent Number:
11548901
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
Triazole carbamate pyridyl sulfonamides as LPA receptor antagonists and uses thereof
Granted: January 10, 2023
Patent Number:
11548871
The present disclosure relates generally to compounds that bind to Lysophosphatidic Acid Receptor 1 (LPAR1) and act as antagonists of LPAR1. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of LPAR1, including fibrosis and liver diseases such as non-alcoholic steatohepatitis (NASH).
Blister pack
Granted: December 27, 2022
Patent Number:
D973511
Pyrrolo[1,2-b] pyridazine derivatives
Granted: December 27, 2022
Patent Number:
11535622
A compound of Formula (I): pharmaceutically acceptable salts thereof, deuterated analogs thereof, compositions thereof, and methods of treating disease using a compound thereof, wherein the variable substituents are disclosed herein.
Blister pack
Granted: December 27, 2022
Patent Number:
D973512
Solid forms of FXR agonists
Granted: December 13, 2022
Patent Number:
11524005
Disclosed herein are novel solid forms of FXR agonists. The disclosure also relates to pharmaceutical compositions containing one or more of the solid forms disclosed herein, as well as methods of using the solid forms in the treatment of conditions mediated by FXR. The disclosure also relates to methods for obtaining such solid forms.
HBV vaccines and methods treating HBV
Granted: November 15, 2022
Patent Number:
11497808
Provided are HBV immunogenic polypeptides, polynucleotides encoding such polypeptides, vectors expressing such immunogenic polypeptides for use in eliciting an immune response against HBV; pharmaceutical and immunogenic compositions and kits comprising such polypeptides, polynucleotides or vectors, and methods of use in treating and/or preventing HBV.
Methods and compounds for treating virus infections
Granted: November 8, 2022
Patent Number:
11492353
Provided are methods for treating Paramyxoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula I: wherein the 1? position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Human parainfluenza and Human respiratory syncytial virus infections.
Remdesivir treatment methods
Granted: November 8, 2022
Patent Number:
11491169
Provided herein are methods of treating or preventing a viral infection in a subject comprising administering a compound of Formula I, Formula Ia, or Formula Ib, or a pharmaceutically acceptable salt thereof, wherein the subject is not being treated with chloroquine, or an analog or salt thereof.
Substituted eneoxindoles and uses thereof
Granted: September 27, 2022
Patent Number:
11453681
The present disclosure relates generally to certain ene-oxindole compounds, pharmaceutical compositions comprising thereof. Also disclosed are methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.
Crystalline forms of tenofovir alafenamide
Granted: September 13, 2022
Patent Number:
11440928
The present invention relates to novel crystalline forms of salts and/or co-crystals of tenofovir alafenamide, the pharmaceutical formulations, and the therapeutic uses thereof in treating viral infections.
Cot modulators and methods of use thereof
Granted: May 10, 2022
Patent Number:
11325930
The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.
Processes and intermediates for preparing MCL1 inhibitors
Granted: May 10, 2022
Patent Number:
11325891
The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.
HIV protease inhibitors
Granted: May 3, 2022
Patent Number:
11318119
The present disclosure provides compounds, or a pharmaceutically acceptable salt thereof as described herein, useful for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject. The disclosure also provides pharmaceutical compositions comprising these compounds, processes for preparing them, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a subject using…
Quinazoline compounds
Granted: April 19, 2022
Patent Number:
11304948
Described herein are compounds of Formula (I) and tautomers and pharmaceutical salts thereof, compositions and formulations containing such compounds, and methods of using and making such compounds.
