Spectrum modeling systems, methods, and devices for particle therapy treatment planning
Granted: February 1, 2022
Patent Number:
11235171
Systems, devices, and methods for non-Gaussian energy distribution modeling for treatment planning algorithms used in particle radiation therapy.
Embolic microspheres
Granted: February 1, 2022
Patent Number:
11235084
In some aspects, the disclosure pertains to injectable particles that contain at least one pH-altering agent that is configured to be released from the injectable particles in vivo, upon embolization of an intratumoral artery of a tumor with the injectable particles. In certain instances, the pH-altering agent may be a basic agent having a pH value of 7.5, a buffering agent having a pKa value of 7.6 or more, or both. Other aspects of the disclosure pertain to preloaded containers…
Dual-monitor computer
Granted: January 25, 2022
Patent Number:
D941818
Systems, methods, and devices for multi-energy x-ray imaging
Granted: January 4, 2022
Patent Number:
11213266
A system can have an x-ray source that generates a series of individual x-ray pulses for multi-energy imaging. A first x-ray pulse can have a first energy level and a subsequent second x-ray pulse in the series can have a second energy level different from the first energy level. An x-ray imager can receive the x-rays from the x-ray source and can detect the received x-rays for image generation. A generator interface box (GIB) controls the x-ray source to provide the series of individual…
Systems, methods, and devices for radiation beam asymmetry measurements using electronic portal imaging devices
Granted: December 28, 2021
Patent Number:
11207546
Systems and methods for determining beam asymmetry in a radiation treatment system using electronic portal imaging devices (EPIDs) without implementation of elaborate and complex EPID calibration procedures. The beam asymmetry is determined based on radiation scattered from different points in the radiation beam and measured with the same region of interest ROI of the EPID.
Bookmarking capability for radiation treatment planning and management
Granted: December 7, 2021
Patent Number:
11195613
A control circuit operably couples to a memory having a plurality of different radiation treatment applications stored therein, a data store having patient data stored therein, and at least a first user interface comprising a first display and a first user input interface. The control circuit can be configured to present simultaneously, via the first display and for a given patient, at least two workspaces that each correspond to a different one of the radiation treatment applications…
Portal dosimetry systems, devices, and methods
Granted: December 7, 2021
Patent Number:
11191979
Systems, devices, and methods for dosimetric verification of radiation therapy treatments by selective evaluation of measurement points. Systems, methods, and computer program-products for providing dosimetric verification of radiation therapy treatments by evaluating measurement points using different evaluation criteria.
Apparatus and method using automatic generation of a base dose
Granted: December 7, 2021
Patent Number:
11191978
A control circuit forms a radiation therapy treatment plan by automatically generating a base dose that references dosing information from multiple sources and then using that base dose to optimize a radiation therapy treatment plan. That radiation therapy treatment plan is then used to administer radiation therapy to a patient. That automatically generated base dose can represent any or all of earlier radiation therapy treatments for the patient, a same fraction as a dose presently…
Systems and methods for planning and executing automated multi-axis motion in treatment
Granted: November 23, 2021
Patent Number:
11179129
An apparatus for creating a radiation treatment plan for execution by a radiation treatment machine, includes: a waypoint module configured to obtain imaging waypoint data representing imaging waypoints, the imaging waypoints at least partially defining one or more positions for obtaining images of a patient during a treatment session; a treatment trajectory module configured to obtain treatment data at least partially defining a beam-on direction; a treatment plan generator configured…
Methods of use of ultra-high dose rate radiation and therapeutic agent
Granted: November 16, 2021
Patent Number:
11173325
Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on…
Iterative image reconstruction in image-guided radiation therapy
Granted: November 16, 2021
Patent Number:
11173324
Reconstruction of projection images of a CBCT scan is performed by generating simulated projection data, comparing the simulated projection data to the projection images of the CBCT scan, determining a residual volume based on the comparison, and using the residual volume to determine an accurate reconstructed volume. The reconstructed volume can be used to segment a tumor (and potentially one or more organs) and align the tumor to a planning volume (e.g., from a CT scan) to identify…
Apparatus and method for real-time tracking of tissue structures
Granted: November 2, 2021
Patent Number:
11160537
A method and system are disclosed for radiosurgical treatment of moving tissues of the heart, including acquiring at least one volume of the tissue and acquiring at least one ultrasound data set, image or volume of the tissue using an ultrasound transducer disposed at a position. A similarity measure is computed between the ultrasound image or volume and the acquired volume or a simulated ultrasound data set, image or volume. A robot is configured in response to the similarity measure…
Clinical goal treatment planning and optimization
Granted: October 26, 2021
Patent Number:
11158408
An apparatus for developing an intensity-modulated radiation therapy treatment plan includes a memory that stores machine instructions and a processor that executes the machine instructions to receive a clinical goal associated with the treatment plan as a user input. The processor further executes the machine instructions to determine a plan objective based on the clinical goal, generate a cost function comprising a term based on the plan objective, and assign an initial value to a…
High DQE imaging device
Granted: October 26, 2021
Patent Number:
11156727
An imaging device includes: a scintillator layer; and an array of photodiode elements; wherein the scintillator layer is configured to receive radiation that has passed through the array of photodiode elements. An imaging device includes: a scintillator layer having a plurality of scintillator elements configured to convert radiation into photons; and an array of photodiode elements configured to receive photons from the scintillator layer, and generate electrical signals in response to…
Method and apparatus for performing irradiation time optimization for intensity modulated proton therapy during treatment planning while maintaining acceptable irradiation plan quality
Granted: October 26, 2021
Patent Number:
11154726
A computer implemented method of determining a resultant treatment plan for a proton radiation therapy system based on given dose volume constraints, wherein the resultant treatment plan is optimized for treatment time comprises accessing the dose volume constraints and range information, wherein the range information indicates acceptable deviations from the dose volume constraints. Based on the proton radiation therapy system, the method further comprises accessing machine configuration…
Blood-tissue surface based radiosurgical renal treatment planning
Granted: October 26, 2021
Patent Number:
11154725
Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric…
Streamlined, guided on-couch adaptive workflow
Granted: October 5, 2021
Patent Number:
11135448
Systems and methods for implementing an adaptive therapy workflow that minimizes time needed to create a session patient model, select an appropriate plan for the treatment session, and treat the patient.
Radiation treatment planning based on dose rate
Granted: September 14, 2021
Patent Number:
11116995
A dose rate-volume histogram is generated for a target volume. The dose rate-volume histogram can be stored in computer system memory and used to generate a radiation treatment plan. An irradiation time-volume histogram can also be generated for the target volume. The irradiation time-volume histogram can be stored in computer system memory and used to generate the radiation treatment plan.
Radiation therapy system using a digital tomosynthesis process for near real-time localization
Granted: September 7, 2021
Patent Number:
11110300
A method of radiation therapy comprises, while a gantry of a radiation therapy system rotates continuously in a first direction through a treatment arc from a first treatment delivery position to a second treatment delivery position, causing an imaging X-ray source mounted on the gantry to direct X-rays through a target volume and receiving a set of X-ray projection images from an X-ray imager mounted on the gantry; determining a current location of the target volume based on the set of…
Creating treatment field using initial field and patient specific geometry and achievable dose
Granted: August 31, 2021
Patent Number:
11103726
Methods and systems are provided for developing radiation therapy treatment plans. A treatment template with radiation fields can be chosen for a patient based on a tumor location. Static radiation field positions can be adjusted for the patient, while arc radiation fields may remain the same. Static radiation field positions can be adjusted using dose gradient, historical patient data, and other techniques.
