Flow meters, flow meter cartridges, and related methods
Granted: November 19, 2019
Patent Number:
10480979
A flow meter for measuring a flow rate of a fluid may include a cartridge containing certain components such as a flow sensor. The cartridge is removable from the flow meter such that it may be replaced with a new cartridge, allowing calibration of the flow meter while enabling the flow meter to continue to be operated with another cartridge in the place of the removed cartridge. The flow meter may be configured to direct fluid flow away from selected components of the flow meter.
Apparatus and method for introducing a sample into a separation unit of a chromatography system
Granted: November 19, 2019
Patent Number:
10478749
An apparatus introduces a sample into a separation unit of a chromatography system with a mobile phase, including first and second mobile phase components. The apparatus includes first and second pump systems, and an injection unit. The first pump system provides the first mobile phase component, first and second portions of the first mobile phase component flowing through first and second branches, respectively. The second pump system provides the second mobile phase component, a first…
Metering device with defined enabled flow direction
Granted: November 12, 2019
Patent Number:
10473632
A sample injector configured to introduce a sample fluid into a mobile phase, wherein the mobile phase is to be driven by a mobile phase drive through a separation unit for separating compounds of the sample fluid in the mobile phase, wherein the sample injector comprises a metering device being operable for displacing fluid and for intaking a metered amount of the sample fluid into the sample injector, an injector valve being switchable for operating the sample injector selectively in a…
Modular pump platform
Granted: November 12, 2019
Patent Number:
10473096
A modular pump platform includes a pump head module, a pump motor module, an electronics module and a separable tray. The pump motor module includes a pump motor having a rotary output removably coupled to a crank shaft of the pump head, the pump motor being one of multiple types of pump motors, and the pump motor module being detachably connected to the pump head module. The electronics module includes an electronic control circuit configured to control operation of the pump motor, the…
Ion throughput pump and method
Granted: October 22, 2019
Patent Number:
10455683
An ion throughput pump (ITP) includes a pump inlet configured to communicate with a vacuum chamber; an ionization source fluidly communicating with the vacuum chamber via the pump inlet and configured for ionizing gas species received from the vacuum chamber; a pump outlet; ion optics configured for accelerating ions produced by the ionization source toward the pump outlet; and a roughing pump stage configured for receiving the ions from the ionization source, producing neutral species…
Functionalized support for analytical sample preparation
Granted: October 8, 2019
Patent Number:
10436684
Aspects of the present disclosure include a solid phase sorbent for preparation of analytical samples. The solid phase sorbent includes particles that are surface modified with an ?-cyclodextrin moiety. Also provided is a method of reducing matrix effects in an analytical sample. In some embodiments, the method includes contacting a sample comprising a matrix-interfering agent and an analyte with ?-cyclodextrin modified particles to produce a contacted sample wherein the…
Superficially porous particles with dual pore structure and methods for making the same
Granted: October 8, 2019
Patent Number:
10434496
Superficially porous particles are provided. Aspects of the superficially porous particles include a non-porous inner core and a porous outer shell that includes inner and outer porous regions. The inner porous region can include ordered cylindrical pores substantially perpendicular to the non-porous inner core. The outer porous region can include conical pores which extend to the surface of the particles and which are in fluid communication with the cylindrical pores of the inner porous…
Bundled fiber optic capillary electrophoresis detection system
Granted: September 10, 2019
Patent Number:
10408790
A multiple capillary florescent detection system employing optical fiber bundles that each fiber bundle has more than one fiber illuminating each sample vessel.
Optical emission system including dichroic beam combiner
Granted: September 3, 2019
Patent Number:
10401221
An optical emission spectrometer system includes a light source and a dichroic beam combiner. The light source emits first light in a first direction and second light in a second direction different from the first direction. The dichroic beam combiner receives the first light via a first light path and the second light via a second light path, reflects a portion the first light into an entrance aperture of a light detection and measurement apparatus, and transmits a portion of the second…
Gas chromatography (GC) column heater
Granted: September 3, 2019
Patent Number:
10401331
An apparatus includes a first column heating apparatus, which includes: a first substrate; a second substrate including silicon; and a first heating element disposed between the first substrate and the second substrate. The apparatus also includes a second column heating apparatus, which includes: a third substrate; a fourth substrate including silicon; and a second heating element disposed between the third substrate and the fourth substrate.
Sample processing apparatus with integrated heater, shaker and magnet
Granted: September 3, 2019
Patent Number:
10399048
Samples in an array of containers are processed by mounting the containers on a sample stage, moving magnets into proximity with bottoms of the containers of a first column of containers to apply a magnetic field, moving the magnets into proximity with bottoms of the containers of a second column, and moving heater elements into proximity with the container bottoms of the first column. While the magnetic field is applied to the containers of the second column, heat energy may be applied…
Ion transfer device for mass spectrometry with selectable bores
Granted: August 20, 2019
Patent Number:
10388501
An ion transfer device for transferring ions from a first chamber to a second, reduced-pressure chamber includes a tube and a bore selector. The tube includes a plurality of tube bores. The bore selector is positioned at an inlet end of the tube and includes an inlet port. The tube is movable relative to the bore selector, and/or the bore selector is movable relative to the tube, to align the inlet port with a selected one of the tube bores while blocking the other tube bores. Alignment…
Rigid piston-actuator-assembly supported for performing a pendulum-type tolerance compensation motion
Granted: August 20, 2019
Patent Number:
10385847
A pump for pumping fluid, wherein the pump includes a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a piston actuator being rigidly assembled with the piston assembly at least in a working mode of the pump to thereby transmit drive energy to the piston assembly to reciprocate along a common rigid axis of the piston-actuator-assembly, and a bearing arrangement bearing the piston assembly and the piston actuator in the…
Experimental chamber with computer-controlled display wall
Granted: August 13, 2019
Patent Number:
10379607
An environmental chamber having an interior compartment, an augmented display, and a controller is disclosed. The interior compartment is adapted for isolating an experimental setup from an environment external to the interior compartment. The augmented display is positioned to allow a user in the external environment to view the interior compartment and an image generated on the augmented display. The controller generates the image. The image includes information about a component…
Impact centrifugal separator and associated methods for fraction collection in supercritical fluid systems
Granted: August 13, 2019
Patent Number:
10376814
A separator (e.g. an impact centrifugal separator) is for use in collection of liquid portions of a bi-phasic flowstream in a supercritical fluid system. A separator chamber defines an interior space, surrounded by a spiral channel and that has an exit at a lower portion of the separator chamber. A flowstream director (e.g. an entry lube) focuses the flowstream so that the flowstream impacts a wail of the spiral channel at an angle that promotes coalescence of the liquid component. The…
Method for enhancing electrospray
Granted: August 6, 2019
Patent Number:
10373816
Provided herein, among other things, is a method of ionizing a first stream of liquid by an electrospray ion source having a nebulizer, wherein the first stream of liquid may comprise an analyte. In some embodiments, the method may comprise: a) providing the first stream of liquid to the nebulizer; b) adding a second stream of liquid to the first stream of liquid, wherein the second stream of liquid comprises a co-solvent that has a relatively high boiling point and an enhancement…
Branching off fluidic sample with low influence on source flow path
Granted: August 6, 2019
Patent Number:
10371671
A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the…
Full field visual-mid-infrared imaging system
Granted: July 2, 2019
Patent Number:
10341583
An apparatus and method for generating images of specimens is disclosed. The apparatus includes an imaging system, controller, and user interface. The imaging system generates a plurality of component images of a specimen, each component image corresponding to a different viewing condition. Each image is represented by an intensity as a function of location on the specimen. The controller stores the component images and generates a compound image from a plurality of the component images.…
Guide RNA with chemical modifications
Granted: July 2, 2019
Patent Number:
10337001
The present invention relates to modified guide RNAs and their use in clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated (Cas) systems.
Chambers for microwave plasma generation
Granted: June 18, 2019
Patent Number:
10327321
A microwave chamber for plasma generation. The microwave chamber comprises a launch structure at a first end of the microwave chamber to accommodate a microwave source for producing microwave energy and a termination section at a second end of the microwave chamber opposite the first end. The termination section is configured to substantially block propagation of the microwave energy from the second end of the chamber. The microwave chamber further comprises an internal wall structure…
