Method for supplying gas for plasma based analytical instrument
Granted: February 19, 2019
Patent Number:
10211038
To achieve an effective gas filtering in a plasma spectrometric apparatus using a gas of a comparatively high consumption flow rate, and to improve the analytical ability, there is provided a plasma spectrometric apparatus containing a sample introducer for producing and delivering an injector gas containing an analyte sample, a plasma generator for generating plasma into which the injector gas is introduced, and an analyzer disposed subsequent to the plasma generator for analyzing the…
Fluid dispensing nozzle assembly
Granted: February 19, 2019
Patent Number:
10207285
The current document is directed to a fluid dispensing nozzle assembly for use with a multi-well synthesizer and in other reagent distribution systems. In certain implementations, a fluid dispensing nozzle assembly comprises a nozzle body with a built-in dispenser tube, a reagent inlet tube, and a fitting that securely connects the inlet tube to the nozzle body. The nozzle body with the built-in dispenser tube and the reagent inlet tube are securely attached to one another by various…
Phosphorous protecting groups and methods of preparation and use thereof
Granted: February 5, 2019
Patent Number:
10196418
Aspects of the present disclosure include compositions that make use of phosphorus and/or nucleobase protecting groups which find use in the synthesis of long polynucleotides. Phosphorus protecting groups are provided that help increase the stepwise coupling yield and/or phosphorous protecting groups that can be removed during the oxidation step. Amidine nucleobase protecting groups are provided that find use in the subject compositions and methods which provides for e.g., increased…
High dynamic range infrared imaging spectroscopy
Granted: January 22, 2019
Patent Number:
10184835
An imaging scanner and a method for using the same are disclosed. The scanner includes a variable attenuator adapted to receive a light beam generated by a MIR laser and that generates an attenuated light beam therefrom characterized by an attenuation level. The scanner includes an optical assembly that focuses the attenuated light beam to a point on a specimen. A light detector measures an intensity of light leaving the point on the specimen, the light detector being characterized by a…
Ion source for soft electron ionization and related systems and methods
Granted: January 8, 2019
Patent Number:
10176977
An ion source is configured for soft electron ionization and produces a low electron-energy, yet high-intensity, electron beam. The ion source includes an electron source that produces the electron beam and transmits it into an ionization chamber. The electron beam interacts with sample material in the ionization chamber to produce an ion beam that may be transmitted to a downstream device. The electron source is configured for generating a virtual cathode upstream of the ionization…
Pre-heater assembly with moderately thermally conductive capillary surrounding
Granted: January 8, 2019
Patent Number:
10173148
A pre-heater assembly (90) for pre-heating a fluid, in particular in a fluid separation apparatus (10), wherein the pre-heater assembly (90) comprises a capillary (200) having a lumen and being configured for conducting the fluid, and a thermal coupling body (202) contacting at least part of the capillary (200), having a value of the thermal conductivity in a range between 8 W/(m K) and 100 W/(m K) and being arrangable so that heat generated by a heat source (80) is supplied to the…
C-probe libraries for DNA target enrichment
Granted: December 11, 2018
Patent Number:
10150960
Provided herein is a method for enriching a target nucleic acid molecule. In one embodiment, the method may involve hybridizing a C-probe to a strand of a target nucleic acid to produce a complex, enzymatically removing any 3? overhanging end from the target nucleic acid of the complex to produce a 3? hydroxyl group at the 3? end; extending the 3? end of the first sequence using the oligonucleotide sequence of the C-probe as a template; enzymatically removing any 5? overhanging end from…
Apparatus and method for dynamically balancing rotors
Granted: December 4, 2018
Patent Number:
10145753
A rotor is statically or dynamically balanced by driving the rotor to rotate at a desired speed, measuring an imbalance in the rotor, calculating an adjustment to be made in a mass distribution of the rotor based on the measured imbalance, and adjusting the mass distribution to reduce the imbalance. Mass adjustment is done by operating a laser to ablate material from the rotor according to operating parameters based on the adjustment calculated. The foregoing is done while the rotor is…
Quadrupole rod assembly
Granted: December 4, 2018
Patent Number:
10147595
A quadrupole rod assembly includes a plurality of electrically conductive rods, electrically insulating rings coaxially surrounding the rods, and clamping systems. The rods are arranged about a longitudinal axis. The rods and rings have respective surfaces oriented in a transverse plane orthogonal to the longitudinal axis, which surfaces interface with respective surfaces of the clamping systems that are also oriented in the transverse plane.
Gas chromatography (GC) column heater control using multiple temperature sensors
Granted: December 4, 2018
Patent Number:
10145823
An apparatus for heating a GC column is described. The apparatus includes first and second temperature sensors. Temperature data are used to set power provided to a heating element of the apparatus.
Fluidic coupling devices, assemblies, and related methods
Granted: November 6, 2018
Patent Number:
10119638
A fluidic coupling device includes a housing, and a piston, spring, and cap insertable in the housing. The spring includes a stack of spring washers and is compressible between the cap and the the piston. The cap is threadedly engageable with the housing and movable into contact with the spring. The device may be coupled to a component in a sealed manner by inserting a ferrule between the piston and the component, inserting a conduit through the housing and into the component, and…
Synchronization of supply flow paths
Granted: October 23, 2018
Patent Number:
10107273
A solvent supply system for supplying a composite solvent is described. The solvent supply system comprises a first supply flow path with a first pump unit, the first supply flow path being adapted for supplying a flow of a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply flow path with a second pump unit, the second supply flow path being adapted for supplying a flow of a second solvent to the mixing unit, the second pump unit operating…
Ion transfer device for mass spectrometry
Granted: October 16, 2018
Patent Number:
10103014
An ion transfer device for transferring ions from one chamber to another, reduced-pressure chamber includes an inlet section and a main capillary section. The inlet section has a lumen and the main capillary section has a bore communicating with the lumen. The inside diameter of the lumen is less than that of the bore. The inlet section may be removable from an installation site separately from the main capillary section. The ion transfer device may be utilized, for example, in an…
Immobilized transposase complexes for DNA fragmentation and tagging
Granted: October 16, 2018
Patent Number:
10100348
The present invention provides a simple and rapid method for preparing purified transposase complexes that are highly suited for fragmenting DNA. The method includes forming transposase complexes with oligonucleotide adapters in cell lysate, then purifying the complexes from the other substance in the cell lysate. Purification is accomplished using a specific binding pair, in which one member of the pair is bound to an oligonucleotide adapter of the complex and the other member of the…
Ferrule with features for softening ferrule crush and related methods
Granted: October 9, 2018
Patent Number:
10094494
A ferrule includes a body surrounding a bore that provides a fluid path along a central axis between a first end and a second end of the ferrule. The body includes a conical section configured for forming a sealing interface with a fitting in which the ferrule may be inserted and a sealing interface with a tube that may be inserted in the ferrule bore. The conical section includes collapse zones configured to collapse in a direction along the central axis in response to axial compression…
Vacuum pump system with light gas pumping and leak detection apparatus comprising the same
Granted: October 9, 2018
Patent Number:
10094381
A rough vacuum pump system includes a primary vacuum pump and a secondary vacuum pump. The primary vacuum pump is an oil-free positive displacement pump, and has an inlet opening, an outlet opening, a compression stage between the inlet and outlet openings, and an intermediate gas passageway that connects to a gas flow path running through the compression stage. The secondary vacuum pump is connected to the intermediate gas passageway of the primary vacuum pump. The compression ratio of…
Fast hybridization for next generation sequencing target enrichment
Granted: October 9, 2018
Patent Number:
10093962
The present invention relates to compositions and methods of target enrichment or selection of nucleic acids using hybridization, which can be used in, e.g., next-generation sequencing.
Double coupling method for oligonucleotide synthesis
Granted: September 11, 2018
Patent Number:
10072261
Aspects of the present disclosure include methods for double coupling a nucleoside phosphoramidite during synthesis of an oligonucleotide. The method can include coupling a free hydroxyl group of a nucleoside residue with a first sample of a protected nucleoside phosphoramidite via an internucleoside P(III) linkage, followed by exposure to an oxidizing agent prior to a second coupling step with a second sample of the protected nucleoside phosphoramidite, and further exposure to an…
Liquid chromatography columns with structured walls
Granted: September 11, 2018
Patent Number:
10073068
A liquid chromatography (LC) column includes a wall having a length along a central axis from the inlet end to the outlet end, the wall enclosing a column interior and having a column radius relative to the central axis, the wall comprising a structured portion configured such that the column radius varies along the length; and a plurality of particles packed in the column interior, wherein at least some of the particles are in contact with the structured portion.
Debris filter for fluidic measurement with recess size decreasing in fluid flow direction
Granted: September 11, 2018
Patent Number:
10073012
A filter for filtering debris out of a fluid flowing along a fluid flow direction in a fluidic member of a sample separation device, the filter comprising a plurality of filter structures stacked along the fluid flow direction and each having pores with defined pore size, wherein the defined pore size of the stacked filter structures decreases along the fluid flow direction.
