Multi-dimensional liquid chromatography with second dimension having a variable flow rate
Granted: November 7, 2023
Patent Number:
11808742
A multi-dimensional liquid chromatography system includes first and second liquid chromatography systems. The first system is configured for providing a first chromatographic separation of a sample fluid comprised in a first mobile phase and to provide a first effluent including at least a portion of the separated sample fluid. The second system is configured for providing a second chromatographic separation of at least a portion of the first effluent comprised in a second mobile phase.…
Mixing fluid by combined axial motion and rotation of mixing body
Granted: November 7, 2023
Patent Number:
11808370
A mixer for mixing a mobile phase in a sample separation device for separating a fluidic sample, wherein the mixer includes a fluid inlet for supplying the mobile phase to be mixed to a mixing volume, a movable body configured for rotating and axially moving in the mixing volume to thereby mix the mobile phase, and a fluid outlet for supplying the mixed mobile phase to a mobile phase consumer.
Headspace sampler
Granted: October 24, 2023
Patent Number:
D1002865
Compositions and methods for performing hybridizations with separate denaturation of the sample and probe
Granted: October 24, 2023
Patent Number:
11795499
The invention provides methods and compositions for separately denaturing a probe and target in hybridization applications. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization applications. Compositions for use in the invention include an aqueous composition comprising at least one polar aprotic solvent in an amount effective to denature double-stranded nucleotide sequences.
Valve arrangement having valve module and base module
Granted: October 17, 2023
Patent Number:
11788647
A valve arrangement includes a valve module and a base module. The valve module includes a stator and a rotor, which is rotatable relative to the stator such that at least one fluid connection is formable between the stator and the rotor. The base module includes at least a part of a force control mechanism for selectively implementing a force-releasing or force-coupling of the rotor and the stator, whereby the valve module and the base module are selectively coupleable to or…
Axially progressive lens for transporting charged particles
Granted: October 17, 2023
Patent Number:
11791149
An electrostatic lens for transporting charged particles in an axial direction includes a first group of first electrodes configured to receive a first DC potential from a DC voltage source, and a second group of second electrodes configured to receive a second DC potential from the DC voltage source different from the first DC potential. The first electrodes are interdigitated with the second electrodes. The first group and/or the second group has a geometric feature that progressively…
Vacuum pump with elastic spacer
Granted: October 10, 2023
Patent Number:
11781553
A vacuum pump includes a housing, a rotatable shaft extending in an axial direction within the housing, a first pumping arrangement including a first stator arrangement and a first rotor arrangement, and a second pumping arrangement including a second stator arrangement and a second rotor arrangement. The vacuum pump further includes a spacer arranged between the first pumping arrangement and the second pumping arrangement. The spacer is coupled between the first stator arrangement and…
Combined degassing and circulation of liquid
Granted: October 3, 2023
Patent Number:
11772012
A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a circulation path along which the liquid can be circulated between a liquid accommodation volume and one of an inlet to a consumer unit consuming degassed liquid or a conduit leading to the inlet, a drive unit configured for circulating the liquid in the circulation path, and a filter in the circulation path for filtering particles or debris out of the liquid,…
Polymerase mutants and use with 3?-OH unblocked reversible terminators
Granted: October 3, 2023
Patent Number:
11773380
Mutant polymerases are provided that have improved ability to incorporate modified nucleotides, including 3?-OH unblocked reversible terminators. The mutant polymerases may be used in a variety of applications, such as for polynucleotide sequencing, primer extension reactions, and template-independent enzymatic oligonucleotide synthesis.
Fluid valve having a coating containing gold and/or platinum
Granted: October 3, 2023
Patent Number:
11773999
A fluid valve for a sample separation apparatus includes a first valve component and a second valve component, which are adjacent to one another and movable relative to one another. The valve components are configured such that, in at least one switching state, at least one switchable fluid channel is formed between the valve components, and at least one part of a surface of at least one of the first valve component and the second valve component is provided with a coating containing…
Drive shaft connector with counterweight and blades for cooling pump motor
Granted: June 27, 2023
Patent Number:
11686311
A fluid pump includes a pump head and a motor coupled by a drive shaft. The pump head includes a pump inlet, a pump outlet, and a pumping stage in which a movable pump element is driven by the drive shaft. The motor includes a motor rotor and a motor stator. A connector couples the motor rotor and the drive shaft. The connector includes a plate rotatable with the drive shaft, fan blades attached to the plate for establishing a flow of air for cooling the motor, and one or more…
Anti-human LAG-3 antibodies and their use in immunohistochemistry (IHC)
Granted: June 6, 2023
Patent Number:
11667711
Provided are chimeric or recombinant antibodies (Ab), or antigen binding fragments thereof, or monomeric or dimeric antigen binding proteins, that can specifically bind to human LAG-3 polypeptides, including human LAG-3 polypeptides expressed on the surface of lymphocytes such as activated T cells that have infiltrated tumors or tumor infiltrating lymphocytes (TILs), and methods for making and using them. In alternative embodiments, chimeric or a recombinant antibodies (Ab), or antigen…
Tip for interface cones
Granted: June 6, 2023
Patent Number:
11667992
A tip including an alloy of platinum and an alloying element chosen from gold, palladium, ruthenium, osmium, iron, cobalt, nickel, copper, zinc, silver, chromium, manganese, titanium, niobium, scandium, vanadium, yttrium, zirconium, molybdenum, tantalum, tungsten, technetium, cadmium, hafnium, rhenium, less than 5 wt. % of iridium, less than 5 wt. % of rhodium, greater than 20 wt. % iridium, greater than 20 wt. % rhodium, and a combination thereof, relative to the total weight of the…
System and method of data-dependent acquisition by mass spectrometry
Granted: May 9, 2023
Patent Number:
11646185
Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are…
System and method of data-dependent acquisition by mass spectrometry
Granted: May 9, 2023
Patent Number:
11646185
Systems, computer-readable media, and methods using mass spectrometry to analyze a sample are provided. For example, a method includes: acquiring a precursor ion spectrum; analyzing the precursor ion spectrum to identify precursor ions that preliminarily match one or more peptides that each belong to at least one protein of interest for the analysis; selecting each of the identified precursor ions in an order according to a ranking protocol for maximizing the number of proteins that are…
Method and apparatus for measuring physiological properties of biological samples
Granted: May 2, 2023
Patent Number:
11639925
The present disclosure relates to methods and apparatus for measuring of multiple physiological properties of biological samples, such as measuring biological flux.
Pressure decoupling fluid drive unit from flow path for pressure adjustment of sample accommodation volume
Granted: April 25, 2023
Patent Number:
11635412
An apparatus for separating a fluidic sample includes a fluid drive arrangement including fluid drive units for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume for accommodating the fluidic sample and selectively fluidically coupleable with or decoupleable from the flow path, and a control unit. The control unit is configured to control pressure decoupling of at least part of at least one of the fluid drive units from the flow path, and…
Synchronization of supply flow paths
Granted: April 25, 2023
Patent Number:
11635065
A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for…
Sample dispatching with fluidic sample retaining
Granted: April 18, 2023
Patent Number:
11630090
A sample dispatcher for a fluid separation apparatus includes a sampling path including a sampling volume, a sampling unit, and a retaining unit. The sampling unit receives a fluidic sample, and the sampling volume temporarily stores an amount of the received sample. The retaining unit receives and retains from the sampling volume at least a portion of the stored sample, and has different retention characteristics for different components of the sample. A switching unit is coupled to the…
Inductively coupled plasma mass spectrometry (ICP-MS) with improved signal-to-noise and signal-to-background ratios
Granted: April 18, 2023
Patent Number:
11631575
In an inductively coupled plasma-mass spectrometry (ICP-MS) system, ions are transmitted into a collision/reaction cell. A DC potential is applied at an exit of the cell at a first magnitude to generate a DC potential barrier effective to prevent the ions from exiting the cell. The DC potential barrier is maintained during a confinement period to perform an interaction. After the confinement period, analyte ions or product ions are transmitted to a mass spectrometer by switching the exit…
