Linoleoylamide based ceramide derivative and its use in cosmetic preparations for the treatment of dry skin
Granted: November 24, 1998
Patent Number:
5840940
The present invention discloses a novel ceramide 3 derivative which is N-linoleoylphytosphingosine (Ceramide IIIA). In addition, a method for preparing this compound is described. The solubility of this diunsaturated ceramide IIIA is much higher than the solubility of ceramide 1 and a saturated ceramide 3 compound. Compositions containing ceramide IIIA are described which are suitable for topical use. Furthermore, a method is given for maintaining the water permeability characteristics…
Transformation of phaffia rhodozyma
Granted: November 24, 1998
Patent Number:
5840528
The present invention discloses a transformed Phaffia strain. Also disclosed are specific vectors for transforming Phaffia, preferably such vectors contain expression regulating sequences obtained from Phaffia. The present invention also discloses the use of certain marker genes in Phaffia. The invention further discloses a method for transforming Phaffia.
Method for producing lipolytic enzymes using transformed Pseudomonas
Granted: November 3, 1998
Patent Number:
5830735
Novel microbial host strains are provided which are transformed by a vector molecule comprising a DNA fragment encoding a lipolytic enzyme and a marker for selection, capable of producing active lipase. Said DNA fragment is preferably derived from a Pseudomonas species.
Cloning and expression of the exo-polygalacturonase gene from aspergillus
Granted: November 3, 1998
Patent Number:
5830737
The exo-polygalacturonase gene from Aspergillus is identified, and the enzyme encoded thereby is expressed. Specifically, the exo-polygalacturonase gene from Aspergillus tubingensis is is cloned and expressed, and DNA sequences from other Aspergillus strains that specifically hybridize therewith are identified. Novel expression vectors that comprise an exo-polygalacturonase encoding sequence, and host cells transformed therewith, are also provided. The invention further relates to the…
Production of fermented food products
Granted: October 27, 1998
Patent Number:
5827552
This invention discloses novel methods of making fermented food products such as yogurt. It also discloses novel Lactobacillus bulgaricus organisms for making fermented food products which are conditionally sensitive, that is, operate to metabolize a desired compound normally under the processing conditions for fermented food products but slow or decrease in activity beyond what is normal under the routine storage temperatures for the fermented food products. Such fermented food products…
Enzyme preparations stabilized with inorganic salts
Granted: October 27, 1998
Patent Number:
5827709
The present invention discloses methods to improve the processing and storage stability of dry enzyme preparations. To this extent an inorganic salt, e.g. MgSO.sub.4, is dissolved in an enzyme containing solution which is subsequently dried, using e.g. spray drying. Not only does the addition of salt improve the yield of enzyme activity upon drying, also the storage and processing stability of the obtained solid composition containing the enzyme and the inorganic salt are improved with…
Antifungal composition
Granted: October 13, 1998
Patent Number:
5821233
Novel compositions that comprise solvates, salts, or other modified crystalline forms of polyene-type antifungal compounds are provided. Representative of such compositions are formulations that comprise the novel cystalline substances .delta.-natamycin and .gamma.-natamycin. Additionally, there are provided methods of preparing or storing such compositions, and also methods of use whereby an enhanced rate of release of antifungal compound, in a pharmaceutical or food products…
Diamine salts of clavulanic acid
Granted: October 13, 1998
Patent Number:
5821364
New diamine salts of clavulanic acid, pharmaceutical compositions comprising the same, and a new process using these diamine salts in the preparation of clavulanic acid and salts and esters thereof have been provided.
Cheesemaking with recombinant aspartic protease
Granted: September 1, 1998
Patent Number:
5800849
A process of producing cheese in improved yields, wherein a recombinant aspartic protease, derived from Rhizomucor miehei or Rhizomucor pusillus, is added to milk in sufficient amounts to effect clotting of the milk, after which the resulting curd is processed in a manner known per se for making cheese.
Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA
Granted: August 18, 1998
Patent Number:
5795733
An overall efficient process for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via 3-(carboxyethylthio)propionyl-7-ADCA, using a Penicillium chrysogenum transformant strain expressing expandase in conjunction with acyltransferase, is provided.
Retinoylamide based derivatives of sphingoid bases
Granted: August 11, 1998
Patent Number:
5792794
The present invention relates to active derivatives of sphingoid bases. Specifically, the invention relates to retinoylamide based derivatives of sphingoid bases. The present invention describes a method for obtaining these compounds. The invention also relates to the use of these compounds in cosmetic compositions.
Cloning of the zymocin gene and use of zymocin in beverages
Granted: July 21, 1998
Patent Number:
5783183
The present invention discloses a method for the preservation of beverages comprising the use of a killer toxin. Specifically, zymocin is used in carbonated drinks. The zymocin is shown to be active against a wide range of different yeast strains. The invention further discloses a DNA fragment encoding zymocin. The DNA sequence is also disclosed.
Electronic equipment enclosure
Granted: June 30, 1998
Patent Number:
D395652
Expression of phytase in plants
Granted: June 23, 1998
Patent Number:
5770413
The present invention provides for the expression of phytase in transgenic plants or plant organs and methods for the production of such plants. DNA expression constructs are provided for the transformation of plants with a gene encoding phytase under the control of regulatory sequences which are capable of directing the expression of phytase. These regulatory sequences include sequences capable of directing transcription in plants, either constitutively, or stage and/or tissue specific,…
Method to alter the properties of acetylated xylan
Granted: June 9, 1998
Patent Number:
5763260
Methods and DNA constructs are provided for the expression of a fungal acetyl xylan esterase gene in microbial hosts. A purified fungal acetyl xylan esterase is obtained which is suited for the use as an accessory enzyme in the degradation of acetylated xylans.
Process for the synthesis of amikacin
Granted: June 9, 1998
Patent Number:
5763587
In the synthesis of amikacin, having the formula: ##STR1## by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economically and the synthesis yield to be improved.
Process for the fractioning and recovery of valuable compounds from vinasse produced in fermentations
Granted: June 2, 1998
Patent Number:
5760078
A process is provided for the preparation of valuable products from vinasse which contains potassium salts. The process comprises concentrating the vinasse to a dry matter content of 50-80% dry solids and separating the formed crystals in a concentration step to form a supernatant which is free of potassium salts. Ammonium sulphate is added to the vinasse before or during concentrating the vinasse.Furthermore, clarification of the supernatant is carried out to provide for the separation…
Diamine salts of clavulanic acid
Granted: June 2, 1998
Patent Number:
5760218
New diamine salts of clavulanic acid, pharmaceutical compositions comprising the same, and a new process using these diamine salts in the preparation of clavulanic acid and salts and esters thereof have been provided.
Oxido reductase enzyme system obtainable from P. chrysogenum, the set of genes encoding the same and the use of oxido reductase enzyme systems or genes encoding the same for increasing antibiotic production
Granted: May 19, 1998
Patent Number:
5753435
A new oxido reductase enzyme activity obtainable from P. chrysogenum, involved in the production of .beta.-lactams, the set of genes encoding said enzyme activity, and a method to enhance said production by using the above-mentioned oxido reductase system and other oxido reductase systems or genes encoding for the same are disclosed.
Acylation method for penicillins and cephalosporins
Granted: May 19, 1998
Patent Number:
5753458
A method for providing a semisynthetic .beta.-lactam antibiotic by enzyme catalyzed acylation of the parent .beta.-lactam with an activated derivative of the side chain acid wherein a modulator, which consists of one or more compounds different from the reactants and the reaction product and which suppresses the hydrolysis of the activated derivative of the side chain acid and the desired product more than it suppresses the synthesis of the desired product, is added to the reaction…
