EXPONENTIAL BASE-3 AND GREATER NUCLEIC ACID AMPLIFICATION WITH REDUCED AMPLIFICATION TIME
Granted: July 30, 2020
Application Number:
20200239878
Described herein are methods and compositions that provide highly efficient nucleic acid amplification. In some embodiments, this allows a 3-fold or greater increase of amplification product for each amplification cycle and therefore increased sensitivity and speed over conventional PCR. Modified bases can be employed in primers to provide this base-3 or greater amplification with satisfactory PCR cycle times, which are improved, as compared to those observed in the absence of modified…
Methods of Detecting Influenza
Granted: April 2, 2020
Application Number:
20200102620
Compositions and methods for detecting influenza are provided.
Methods of Detecting Bladder Cancer
Granted: December 19, 2019
Application Number:
20190382847
Compositions and methods for detecting bladder cancer are provided. In some embodiments, methods of detecting low grade bladder cancer are provided. In some embodiments, methods of monitoring recurrence of bladder cancer are provided. In some embodiments, the methods comprise detecting androgen receptor (AR) and/or uroplakin 1B (UPK1B).
Methods of Detecting Trichomonas Vaginalis
Granted: August 15, 2019
Application Number:
20190249264
Compositions and methods for detecting Trichomonas vaginalis are provided.
METHODS OF DETECTING INFLUENZA
Granted: September 28, 2017
Application Number:
20170275712
Compositions and methods for detecting influenza are provided.
METHODS OF DETECTING TRICHOMONAS VAGINALIS
Granted: June 29, 2017
Application Number:
20170183746
Compositions and methods for detecting Trichomonas vaginalis are provided.
METHODS OF DETECTING LUNG CANCER
Granted: April 21, 2016
Application Number:
20160108478
Methods of detecting lung cancer, such as non-small cell lung cancer, including squamous cell carcinoma and adenocarcinoma, are provided. Methods of detecting changes in the levels of one or more small RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
METHODS OF DETECTING CANCER
Granted: January 28, 2016
Application Number:
20160024586
Methods of detecting cancer are provided. Methods of detecting changes in the levels of one or more small RNAs associated with cancer are also provided. Compositions and kits are also provided.
METHODS OF DETECTING SEPSIS
Granted: December 31, 2015
Application Number:
20150376699
Methods of sepsis in a sample from a patient are provided. Methods of detecting changes in expression of one or more RNAs associated with sepsis are also provided. Compositions and kits are also provided.
METHODS OF DETECTING LUNG CANCER
Granted: December 31, 2015
Application Number:
20150376711
Methods of lung cancer in a sample from a patient are provided. Methods of detecting changes in expression of one or more target RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
METHODS OF DETECTING CHLAMYDIA AND GONORRHEA AND OF SCREENING FOR INFECTION/INFLAMMATION BASED ON GENOMIC COPY NUMBER
Granted: December 31, 2015
Application Number:
20150376683
Compositions and methods for detecting Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are provided. The present invention also provides methods and compositions for screening for infection/inflammation based on genomic copy number. Described herein is a method that entails assaying a sample obtained from the urogenital tract of the mammal for an indicator of genomic copy number, wherein a genomic copy number level that is higher than a control genomic copy number level is…
TWO-PRIMER PCR FOR MICRORNA MULTIPLEX ASSAY
Granted: November 12, 2015
Application Number:
20150322510
The present invention provides method for amplifying a specific RNA molecule in a sample, the method comprising: (a) adding a poly(ribonucleotide) sequence to RNA molecules in the sample; (b) reverse transcribing the poly-adenylated RNA molecules using a reverse primer comprising a sequence that anneals to said poly(ribonucleotide) sequence; and (c) amplifying and detecting the cDNA molecule(s) using the same reverse primer and using a forward primer specific for the RNA molecule to be…
HONEYCOMB TUBE
Granted: October 1, 2015
Application Number:
20150275292
A honeycomb tube with a planar frame defining a fluidic path between a first planar surface and a second planar surface. A fluidic interface is located at one end of the planar frame. The fluidic interface has a fluidic inlet and fluidic outlet. The fluidic path further includes a well chamber having an well-substrate with a plurality of wells. The well chamber is arranged in the planar frame between the first or second surface and the well-substrate.
APPARATUS WITH HETEROGENEOUS PROCESSING MODULES
Granted: April 30, 2015
Application Number:
20150119268
A biological sample processing apparatus having an enclosure. A plurality of sample processing modules are held by the enclosure. Each sample processing module is configured to hold a removable sample cartridge and to only perform sample processing on a sample within the corresponding removable sample cartridge. Each sample processing module is configured to perform at least one of a plurality of testing processes on the sample within the removable sample cartridge. At least one module…
REAGENT RESERVOIR SYSTEM FOR ANALYTICAL INSTRUMENTS
Granted: December 25, 2014
Application Number:
20140377759
The invention provides a reagent reservoir system and disposable reaction cassettes using the same. In one aspect, such system comprises a chamber in which dried reagent, particularly lyophilized reagent, is constrained to remain in a defined region of the chamber by a retaining member that obstructs passage of such reagents to other regions of the chamber where they may escape hydration or activation.
METHODS OF DETECTING LUNG CANCER
Granted: November 27, 2014
Application Number:
20140349869
Methods of detecting lung cancer, such as non-small cell lung cancer, including squamous cell carcinoma and adenocarcinoma, are provided. Methods of detecting changes in the levels of one or more small RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
METHOD AND APPARATUS FOR STORING AND DISPENSING REAGENT BEADS
Granted: November 13, 2014
Application Number:
20140335627
Embodiments of the invention provide an efficient and effective technique for storing and dispensing reagent beads. In some embodiments, an apparatus is provided for dispensing reagent beads contained in a bead storage device which includes a bead carrier having a plurality of wells; a plurality of reagent beads disposed in the wells; and a cover tape releasably attached to the bead carrier to cover the wells and retain the reagent beads in the wells. The apparatus comprises a channel in…
FLUID PROCESSING AND CONTROL
Granted: October 2, 2014
Application Number:
20140295479
A fluid control and processing system for controlling fluid flow among a plurality of chambers comprises a body including a fluid processing region continuously coupled fluidicly with a fluid displacement region. The fluid displacement region is depressurizable to draw fluid into the fluid displacement region and pressurizable to expel fluid from the fluid displacement region. The body includes at least one external port. The fluid processing region is fluidicly coupled with the at least…
MULTI-CHAMBERED LID APPARATUS
Granted: September 25, 2014
Application Number:
20140284338
A lid apparatus for a multi-chambered container. The lid apparatus has a top-lid that is hingedly attached to a bottom-cap. The top-lid includes one or more openings for fluid filling multiple passages that extend from the bottom-cap. A lower bottom-cap includes welding features for welding to the multi-chambered container.
METHODS OF DETECTING LUNG CANCER
Granted: July 17, 2014
Application Number:
20140200153
Methods of lung cancer in a sample from a patient are provided. Methods of detecting changes in expression of one or more target RNAs associated with lung cancer are also provided. Compositions and kits are also provided.
